Chapter 62:

"These sets of experiments are carried out simultaneously. Pay attention to recording the time." Li Zheng looked up at Zheng Lingling who had come in with protective clothing, and nodded to her. "There are not so many protective clothing in the laboratory, so let them not enter the room. There are drinks and desserts in the refrigerator in the laboratory. You can entertain the students."
Speaking of food, Li Zheng's right hand touched his stomach unconsciously. Yesterday he didn't have time to eat instant noodles before Zhang Yuejun ran in. Yesterday’s instant noodles were probably still on the table in Lab 2...
"Gurulu~" His stomach made a very unfavorable noise.
Li Zheng's mouth pursed into a straight line.
Zheng Lingling looked at Li Zheng and said, "You didn't eat? You didn't eat dinner or breakfast." She knew Li Zheng's lifestyle, eating instant noodles for three meals a day, and was hungry when she forgot.
She had just asked the agency to send a job advertisement for aunts two days ago. She wanted to pick another two days, but seeing what Li Zheng looks like now, she thinks it would be better to lower the requirements and let the aunts start early.
Li Zheng was silent for a while, and Yu Guang swept over Zhang Yuejun, who kept recording data, and the little nurse who carefully classified the data, and said: "Ten minutes of rest, let's eat some bread to fill our stomachs." He remembered whether there was anything left in his refrigerator. Less bread.
After speaking, he took the lead to walk out of the laboratory.
"Li Zheng...Are you doing experiments? Researching new drugs?" Someone couldn't help but ask when Li Zheng came out.
Li Zheng smiled and shook his head, "Don't count. The P3 laboratory of No. 1 laboratory is not open to the public during the project. If you are interested, you can check out the other laboratories." He said, feet. There is no sign of stagnation in the pace.
Li Zheng's detached attitude in his politeness made everyone a little embarrassed. But Li Zheng now has no intention of paying attention to the crookedness of the children's hearts. After the whole night of experiments, his mood has become more and more serious.
They tried all the available antibiotics. According to the response of resistant bacteria to antibiotics, the most likely ones are Pseudomonas aeruginosa and Streptomonas maltophilia.
If after twenty years, Li Zheng can tell many treatment options with his eyes closed, such as aminoglycosides (amikacin) + cephalosporin third generation (Supsen, ceftazidime) or quinolones (ciproxazole) Star) + cephalosporin third generation (Supsen, ceftazidime), or ciprofloxacin + β-lactam enzyme inhibitor (tezhixing) and so on.
But now, in 1983, many of the drugs in these programs have not yet been on the market.
"Li Zheng, it’s not good for you to stay in the laboratory all the time. Sometimes it’s inspiration to go out for a walk. It’s the practice of our medical school to go to the hospital as a volunteer, so go with us." The girl with the apple face Obviously not giving up.
Li Zheng took out the bread and milk from the refrigerator, and distributed them to Zhang Yuejun and others, "No, my experiment is at a critical juncture. Wang Jing, you will go back to the hospital next time. I need the patient's medication record and case status last night. Also, I just wrote several combinations of medications on the white paper I just gave you. You ask Professor Chen to try and tell me the patient's clinical response before noon."
"Zheng Lingling, let someone send a group of guinea pigs over. I'll be useful later."
"Okay." Wang Jing and Zheng Lingling nodded immediately. Wang Jing didn't stay too much, greeted Li Zheng, and ran out with the milk and bread in his mouth. As a nurse, she knew it was right. What does the patient mean.
Li Zheng stuffed his last bite of bread, looked at the watch on his wrist, and walked back for exactly ten minutes for seven minutes.
The apple-faced girl saw that Li Zheng was about to leave after a few minutes, and she couldn't help standing up anxiously. She reached out to grab Li Zheng's arm, but was flexibly blocked by Zheng Lingling.
"Aren't you going to be volunteers? Go ahead. It's a matter of time before it's too late." Zheng Lingling knew that he was in trouble this time when he stepped into Lab 1. Well, she admits that she is indeed a little proud, especially after the Governor and the Governor’s wife had a cordial conversation with her at the opening ceremony of the Li Zheng laboratory, even the elder relatives in her family talked about it with a little bit of honor feel.
This taste of being affirmed by an individual rather than a family made Zheng Lingling a little bloated.
Although Li Zheng didn't talk about her today, she could see the dissatisfaction in Zhang's eyes. Zheng Lingling touched her nose. No, she had to make up for it.
"but……"
"Nothing. The student union is familiar with major hospitals. I'll help you get in touch!"
A group of students saw Zheng Lingling's firm attitude, and they didn't say much. When a group of people was walking outside, they happened to see seven or eight medical school professors walking quickly towards the green garden.
"Where is Li Zheng?" Professor Zhao asked directly when he saw Zheng Lingling.
Seeing the dignified expressions on the faces of the professors, Zheng Lingling couldn't help but feel stunned, "Li Zheng, he just entered the laboratory."
The classmates hurriedly greeted him, and Professor Zhao swept across the students, his brows frowned into a Sichuan word, "What are you doing here, don't hinder Li Zheng from doing business!"
Everyone look at me, I look at you, speechless.
The professors did not pay attention to what they meant, and after receiving the message from Li Zheng in Laboratory 1, they immediately walked towards the laboratory.
When the professors arrived, Li Zheng and Zhang Yuejun were recording the third group of drug-resistant bacteria. Looking at the newly released data, Li Zheng was already 90% sure that the drug-resistant bacteria this time was Pseudomonas aeruginosa. bacteria.
Damn it! He slammed off the table hard.
Professor Zhao saw this scene when he came in, and his heart suddenly lifted.
"How about it, are there any results?" A group of professors put on protective clothing carefully and walked into the laboratory.
Li Zheng didn't say much, and passed the data in his hand to Professor Zhao.
When Professor Zhao saw the experimental data, the expression on his face became more serious, and he presented the data to a group of professors.
After a long time, someone said with difficulty: "Is it a multi-drug resistant bacteria?"
Li Zheng nodded.
There was silence in the laboratory. The multi-drug-resistant bacteria in the 1980s were also a clinical problem that made people famous in Western and European countries where the medicine was the most advanced, let alone in Xiangjiang.
As far as they know, it is difficult to find the existing antibiotics that can combat the existence of Pseudomonas aeruginosa.
"I called Lao Chen in the morning, Lao Xu's high temperature can no longer be controlled, and the wound is very inflamed. Lao Chen used three antibiotics at night, but there was no much response." Professor Wang's voice was low.
Although Xu Mingsheng is a little temperamental, he is very righteous, fighting for the medical school to fight for the project, and none of the professors here has benefited from him.
Li Zheng's nails were sunken deeply into his own flesh. He took a deep breath and tried to make his brain work normally. There is still time, it's not over yet!
Yes, he still has time.
Pseudomonas aeruginosa is only sensitive to carbapenems, so he developed a carbapenem drug!
Carbapenem antibiotics are a class of β-lactam antibiotics modified from the structure of penicillin. They were applied clinically in the mid to late 1980s. There should have been carbapenem antibiotics developed by pharmaceutical companies, but they are still in the secret trial stage and have not been promoted for clinical use.
In his previous life, Li Zheng focused on vaccines and cells, and he was really not proficient in antibiotics, but fortunately, vaccinology has a lot in common with it, which prevents him from becoming a headless fly.
Li Zheng remembers that the carbapenem antibiotics include imipenem-cilastatin, panipenem, meropenem, etc. Among them, imipenem-cilastatin is the first carbapenem to be marketed. Class antibiotics, the rest are developed with reference to press penem.
Li Zheng took out two penicillins from the experimental refrigerator. The structure of carbapenems is similar to the penicillin ring of penicillin, so he had to start from scratch.
"Professors, do you believe me?" Li Zheng said suddenly.
The professors were startled at first, and then reacted. Professor Zhao said: "Do you have a way?"
Li Zheng took out an appropriate amount of penicillin and poured it into a test tube. "Time always goes by every minute and every second. You try to go like this, but if you pass it passively, you still go like this. Why don't you try?"
Li Zheng said it lightly, but in the hearts of a group of professors, it was like throwing a boulder into a calm lake. Yes, they are sad and annoyed here, and it doesn't help. Why not try hard.
Their colleagues are still lying in the hospital bed, there are more than 100 lives, and the fate of more than 100 families and hundreds of people after these more than 100 lives! They have any reason not to try hard!
The gazes of the professors became serious. At such an age, they were not as enlightened as a young man, and they couldn't help but feel a little bit ashamed.
"Li Zheng, do you have eyebrows? To tell you the truth, our old guys are not at all eyebrows. If you have eyebrows, don't have any scruples. Please give orders at any time and strike a hand. We are no worse than that young man!" Said boldly.
A group of professors nodded one after another. By their age, fame had gained status, and they didn't value these certain things very much. They didn't feel ashamed of hitting a seventeen-year-old boy.
Li Zheng's expression finally eased a bit after hearing the words, "I have a rough idea." As he said, he drew the structure of the penicillium ring on the blackboard in the laboratory, and then, under the bright eyes of the professors, slowly Change the penicillium ring.
"Carbapenems, a whole new class of antibiotics."
Li Zheng's words were loud and loud, making everyone present stay in place, brand new antibiotics? Did they hear me wrong? ?