Chapter 743: More than just upgrading!

What Academician Zhong saw was beyond words. A problem that the whole world could not solve was suddenly solved at this time on the first day of the Chinese New Year?
At this moment,
Academician Chu on the other side of the phone heard the rapid breathing of his colleague Lao Zhong, and he was a little dazed for a while, and asked curiously: "Lao Zhong...what did you see? Why do you feel that your breathing is starting to rush Up?"
"I..."
"I can't believe... what I saw." Academician Zhong said sincerely: "It's solved! It's finally solved... I simply compared the two data reports, and the final result is almost a touch..."
The words came to an abrupt end here.
What Academician Zhong wanted to say suddenly got stuck in his throat, his expression changed from shock to a little horrified, as if he had seen something that subverted his perception.
"wrong!"
"No, right, right!" Academician Zhong repeated a vocabulary with horror on his face, and the hand that controlled the mouse kept sliding the wheel, his eyes became a little frightened at this moment, and he discovered something that was impossible to exist.
"what happened?"
"What the is going on?" Academician Chu was going crazy at this time, and he wished that wings appeared on his back, and then flew to Academician Zhong to see what he saw. This mysteriously stunned people's appetite.
"Professor Xu Mang...he...he replaced the original Cas9 with another RNA-guided nuclease in the new CRISPR-Cas gene editing system." Academician Zhong said in surprise: "This is incredible. .. so... amazing!"
Academician Chu:? ? ?
The more invisible things, the more I want to have them.
Academician Chu was going crazy, listening to the constant exclaims of his colleagues, bit by bit, he was eating away his curiosity, and he was about to collapse at the last point.
"God!"
"He is more than upgrading the CRISPR-Cas gene editing system. Professor Xu Mang has also solved a...a problem that bothers all biologists in the world!" Academician Zhong hurriedly said: "He redesigned the C2c1 nucleic acid Enzymes, now... C2c1 nuclease is fully adapted to most organisms!"
Suddenly,
Academician Chu has completely collapsed. If the successful upgrade of the CRISPR-Cas gene editing system is only the beginning, then the redesign of the C2c1 nuclease is the last straw that crushes the camel.
C2c1 nuclease has thermophilic characteristics, which is impossible to develop into a gene editing tool, and the key is that the original structure of C2c1 nuclease will cut the non-target single strands in double-stranded DNA. The lower the temperature, the more errors will be caused. Editing efficiency is low.
This problem is a problem for the whole world. Many teams have tried but failed... But Professor Xu Mang managed to break this dilemma?
This...
Is this killing two birds with one stone?
"Old clock!"
"Hurry up and send me the data!" Academician Chu couldn't wait to urge: "I was itching for you... Hurry, hurry... Hurry and send me, this so-called redesign of the C2c1 nuclease, after all what's going on?"
"Ahem!"
"The above only introduced the effect of the redesigned C2c1 nuclease, but did not give a detailed report." Academician Zhong frowned and said solemnly: "Wait a moment... I need to give Professor Xu Mang one Call and ask what is going on."
Words fall,
Academician Zhong directly hung up the call, and then hurriedly called Xu Mang over.
"Hey?"
"Professor Xu... you redesigned the C2c1 nuclease. Is this true?" Academician Zhong asked nervously, "Are there any relevant research reports? And this needs to be verified by experiments, just by AI simulation Not enough to be convincing."
Xu Mang said indifferently: "There are related research reports, although they have not been verified by experiments, but from the research reports on C2c1 nuclease from all over the world, using AI technology... the results have been completely obtained. C2c1 nuclease is not impossible. For gene editing, it is very suitable."
"simply speaking..."
"The CRISPR-C2c1 gene editing system I developed has higher sensitivity, can realize sensitive DNA detection, and can realize single-base discrimination." Xu Mang smiled and said: "With my gene editing system, it can be realized quickly. Bacterial and viral infections, genotyping and SNP mutation detection in cells, blood, animals and plants."
"I'll let Xiaozhang and Xiaocai help me get the data for the experimental part in a minute." Xu Mang smiled and said, "By the way...Can Academician Zhong apply for a patent?"
"..."
"can!"
"You have to give us free use." Academician Zhong said hurriedly: "That's right... Call me as soon as the results are available."
"Ok!"
"I want to publish on "Nature", shouldn't it be possible?" Xu Mang asked.
Academician Zhong hurriedly said: "It's totally possible!"
hang up the phone,
Academician Zhong sent all six materials to his old friend's email address, but after only half an hour, he received a call from Lao Chu.
"This..."
"This is unbelievable!" Lao Chu said with surprise: "Just a research report on the redesigned C2c1 nuclease. If Xu Mang can publish it, it will be even more perfect!"
"This is just the initial stage... like this kind of brand new gene editing system, we must continue to use experimental data to accumulate and continue to improve on the original basis, but... being able to propose such a framework concept is enough to prove Xu Mang's greatness. Academician Zhong smiled bitterly: "Old Chu...had to feel that the back waves of the Yangtze River pushed the front waves, and each wave was stronger than the other."
at the same time,
Xiao Zhang and Xiao Cai were helpless, and they were caught by Xu Mang again, but this time they did not complain. They came into contact with Xu Mang's latest research results about the redesigned C2c1 nuclease.
at this time,
The two are conducting related experiments for this brand new CRISPR-C2c1 gene editing system, and at the same time more detailed processing of the C2c1 nuclease.
And this process,
It took two full days. For Xu Mang, these two days didn’t feel much, just sitting in the laboratory knocking melon seeds and sending WeChat with Xiaoman, but for Xiao Zhang and Xiao Cai, The harvest in these two days is great.
As a new intern researcher of the institute, he rarely has access to such top research projects. However, Professor Xu Mang can not care about his own experience and allow himself to join this research and become a part of this research. This kind of kindness is almost nothing. In return.
"Ok?"
"This speed is okay..." Xu Mang said with a smile, "You can go to rest...or go outside, and study all I am here."
Not to mention,
At this time, the two were exhausted, and after greeted Xu Mang, they hurried back to their dormitory.
Xu Mang checked the relevant research report, went to his office silently, turned on the computer and started editing the paper, and wrote the name of the paper-"CRISPR-C2c1 Gene Editing System" at the beginning.
...
London,
The headquarters of the famous scientific magazine "Nature",
Originally speaking to the editors of "Nature" on this day, it was an ordinary day, but some people did not want to make this group of people live too easily. At this time, a paper that is about to shock the world is quietly coming to Pete. Editor's mailbox.
"The top ten people of the year in "Nature" will be published in the order of this list." Editor-in-chief Peter said to one of his men: "Be careful of the order."
In the list submitted by the editor-in-chief of Pete, Xu Mang was ranked first. There is no way...Although the entire Western world does not want to see Xu Mang ranked first, his achievements this year are no longer possible. Use shady to control it.
"Editor in chief Peter..."
"Let the Chinese come first...many people are very upset." The young editor said, "Why... move back a bit?"
"No!"
"I can't move at all." The editor-in-chief of Pete said seriously: "Look at the achievements of the next nine, and they add up to only half of Xu Mang's. Do you think there is any theory not to let Xu Mang be the first?"
For a while,
The young editor is speechless, this is really the case.
moment,
The editor-in-chief of Pete is left in the office. I don't know what happened recently. The quality of the paper is very poor, and the man he was looking forward to has never appeared, probably because Hua Guo is at this stage of what they call Chinese New Year.
Uh?
New email alert?
It shouldn't be Xu Mang, he is celebrating the most important festival in China, in that case...who sent this?
Editor-in-Chief Pete didn't care, nor did he click to open it, silently doing his own thing. At this time, he put the email just now into the category of unfamiliar contributors.
Bang bang bang,
There was a knock on the door outside the office, and after an invitation to enter, a middle-aged man walked in.
"Pitt editor-in-chief ~EbookFREE.me~ these three papers, which one should you choose as the cover paper?" The middle-aged man handed the short text articles of the three research reports to Peter.
After reading it briefly, the editor-in-chief of Pete revealed a trace of dissatisfaction, and said seriously: "It is not shocking enough...Although it can be placed in the main journal, it must not be placed on the cover. These three research reports did not allow I am excited."
This middle-aged man is very helpless, how can there be so many papers that can shock the whole world.
"Editor-in-chief Peter...the quality of recent papers is generally not high, maybe Valentine's Day is coming..." The middle-aged man smiled bitterly: "Many young scientists also need a touch of romance."
"..."
"It doesn't seem to have anything to do with Valentine's Day. It's just a low point." Pete smiled and said, "Wait a little longer...Anyway, there are still two days. Maybe in these two days, I can shock the world. Research report."
At this time,
Pete opened his mailbox and saw the name of the first email-"CRISPR-C2c1 Gene Editing System".
"Uh?"
"By the way, do you know what the CRISPR-C2c1 gene editing system is?" Pete was taken aback when he saw the email title, and asked curiously: "I remember... there is no CRISPR-C2c1 gene editing system in this world, right?"
"should not."
"CRISPR-Cas9 gene editing system does exist, and it is currently very popular in the biological field." The middle-aged man said.
Pete frowned, and subconsciously clicked on the email.
Just a few seconds,
Pete shouted in horror: "It's him!"
......