Vol 2 Chapter 256: God's Blood and Genetic Engineering

Soon, Richard saw Gutas' suicide, that is... hunger strike.
Gutas is full of confidence in this, but Richard is not mindful.
then……
On the first day of the hunger strike, Gutas was alive and kicking.
On the second day of the hunger strike, Gutas was as usual.
On the third day of the hunger strike, Gutas remained unchanged.
The fourth day of hunger strike.
Laboratory, main laboratory.
Gutas was sturdyly tied to the chair, and Richard took a certain amount of blood from the other's arm and put it in a test tube.
Turn around and insert a special needle into the veins of Gutas. Behind the needle is a leather tube and a weird device. Behind the leather tube is a glass bottle. The glass bottle is configured with a concentration of 0.9%. Physiological saline, and glucose solution with a concentration of 5%.
Gutas looked at Richard's operations immobilely, his eyes full of resentment.
Richard was calm and even smiled a little bit: "To be honest, you should go on a hunger strike two days earlier. After all, compared to eating, only 600ml of saline plus 120ml of glucose can be satisfied by infusion. The daily needs of the human body.
The physiological saline can be arbitrarily configured, and only salt and water are needed. Glucose may be a little troublesome, but it can be obtained by acid hydrolysis of some starches. No matter how you look, it's easier than feeding you food. Of course, this is a bit anti-human. I didn't plan to do this at first, but you chose this method yourself, and I couldn't help it, did you?
In other words, this way of maintaining life can not be too long, otherwise it will cause malnutrition. But it doesn't matter. Wait a while, I can give you liquid food by nasal feeding to supplement the nutrition that the infusion can't get. At that time, it is more painful to need to insert the gastric tube. You must prepare yourself in advance. After all, it's all my choice, right? "
Gutas already had some despair in his heart, he fully understood the truth: falling into the hands of Richard, he would never die!
This... is absolutely, no matter whether it is dead or not!
shameless!
...
In Gutas' despair, many days passed.
Laboratory, main laboratory.
Under the candlelight, Li Cha quickly wrote the experiment notes with a quill pen.
"Shusha..."
"...The experiment went well and the results were as expected..."
"...The theory obtained is slightly different from the previous one, but in the right direction..."
"... The extreme amplitude-increasing hormone that was difficult to extract was injected back into the test subject, and the test subject produced an increase similar to the third peak of the previous experiment, while the second peak and the first peak were weakened. It shows that there is a negative feedback adjustment phenomenon.
That is, the medicament promotes the body to secrete the'maximum amplification hormone', and the'maximum amplification hormone' stimulates the blood glands to secrete the'maximum amplification hormone'. While the'Extreme Amplification Hormone' is functioning, it will inhibit the'Extreme Amplification Hormone' and the agents from continuing to work..."
"...In summary, the mechanism of action of the secrets of Blood Vessel Seeds and the Spartan Heroic Elixir is summarized below.
When ordinary people use medicaments: medicaments → regulate the human body, exert an amplification effect, and release the ‘promoting limit amplification hormone’ → termination.
When the blood vein seed activates power: blood gland → secretion of ‘ordinary amplification hormone’ → regulation of human body, exerting amplification effect → termination.
When blood vein seed activates strength and uses medicine: medicine → adjust the human body, exert the effect of amplification, and release the'promoting limiting amplitude hormone' → stimulate the blood glands → secrete the'limiting amplitude hormone' → adjust the human body to exert the third peak-type amplification effect , The ability to explode beyond the limits of the human body → termination.
..."
After a pause, Li Cha took his eyes seriously and continued to write on the papyrus scroll as an experimental note:
"Through the above, the most valuable part of this theory is undoubtedly the use of the limit-amplification hormone. The specific mechanism of action of this hormone on the human body is not yet clear, but the role played is beyond imagination, and only requires a very small amount. It is not an exaggeration to turn an ordinary person into a "superman" and call it "the blood of God".
But how to use it is a huge problem.
The first is the difficulty of extraction, there are many links to be overcome, the success rate is not high, the output rate is extremely low, the process is unstable, and the cost is high.
In addition, the source is scarce, and it must be provided by a test product with blood vein seeds, and large-scale production cannot be performed. In fact, small-scale production is impossible. At present, it can only meet a very small number of laboratory tests and cannot be used in practice. "
"call--"
With a breath, Richard stopped writing and thought.
At present, the research on Sparta's heroic potions and blood vein seeds has fallen into a bottleneck. The biggest research result-"Blood of God" has been confirmed, but it cannot be used.
It's like trying to guess the lottery jackpot number, but because you are missing two dollars, you can't buy a lottery ticket.
How to solve it?
Richard rubbed his brow hard.
How do hormones like "blood of the gods" solve problems on modern earth and how to achieve mass production?
In the modern region, the most representative case should be...insulin.
Well, insulin.
Insulin is a protein hormone secreted by pancreatic islet β cells in the pancreas. It is the only hormone in the body that lowers blood sugar and is the main drug used in the treatment of diabetes.
Therefore, insulin was discovered in 1921 and was used clinically in 1922 to treat diabetes-before insulin was found, diabetes was a cancer-like death.
With the development of the times, the acceleration of urbanization and the extension of human lifespan, the number of diabetic patients continues to increase-in the modern urban living environment, for every 10 years of age, the prevalence of diabetes increases by 68%-therefore, the number of insulin needs is linear rise.
Initially, people extracted insulin from animals, such as cattle, sheep, and pigs. The amino acid sequence and structure of the insulin molecules of these mammals have certain differences. Among them, porcine insulin is the closest to humans. People obtain insulin from pigs to treat diabetes-this is the first generation of insulin.
However, porcine insulin, the first-generation insulin, differs from human insulin by 1 to 4 amino acids~EbookFREE.me~ It is easy for immune reactions, atrophy or hyperplasia of subcutaneous fat at the injection site, and insulin allergic reactions. Because of its high immunogenicity, it is prone to repeated occurrence of hyperglycemia and hypoglycemia and insulin resistance. Most importantly, due to the number of live pig pancreas, the yield is not very high.
So after decades of research, people developed the second generation of insulin.
The second generation of insulin is the use of genetically engineered (recombinant DNA) yeast (Saccharomyces cerevisiae, Pichia yeast or Hansen yeast), recombinant Chinese hamster ovary cells (CHO), etc. to express high-purity synthetic human insulin. Its structure is the same as the insulin secreted by the body itself, eliminating many defects of the first generation of insulin. And can use tissue cultured microorganisms, or transgenic animals, for large-scale production, widely used to treat patients.
The subsequent third-generation insulin was also developed on the basis of the second-generation insulin. Using genetic engineering technology to change some structures on the insulin peptide chain, an insulin analogue that is more suitable for the physiological needs of the human body is developed and can be used before meals. It is called meal-time insulin or fast-acting insulin.
Overall, in short, the way to solve this problem on modern earth is... genetic engineering.
"Genetic engineering." Li Chaning said, all thought.