Chapter 361: Gene chip and gene target

A list of books sent away sister Wen Wan.
Seeing sister Wen Wan's trembling shoulders, Lu Li smiled and nodded. Although the basics are poor, the learning attitude is still very correct! After getting my book list, she was excited!
This is similar to... the excitement of elementary school students after receiving a box of practice questions?
Greed my body? You are thinking of peaches!
How can I have that time in the U.S. to have love with you? Why not go back and do an experiment...
Well, Professor He kicked me out of the laboratory.
Then give the chicken a vacation...Bah, give yourself a vacation!
Lu Li turned and walked out of the research institute, ready to go out and move around.
Just walking to the gate of Fudan School, Lu Li suddenly saw a very familiar figure.
In March, catkins flew up and down.
The breeze blows the weeping willows by the roadside, like rippling silk ribbons.
A woman in a light-colored spring dress, strolling in the shade of the trees, walks lightly in lotus, and comes in styles.
"Liu Qin?"
Lu Li was shocked. In this plot, he could still meet Liu Qin? It's... so unexpected.
"Land from?"
Hearing this call, Liu Qin quickly raised his head and saw Lu Li standing at the intersection ahead.
The upright figure, handsome face, and the unabashed surprise on his face made Liu Qin's heart trembled inexplicably.
Reaching out and stroking the hair around his ear, Liu Qin smiled and walked up.
"Lu University scientist, old classmates are here to visit, are you welcome?"
Walking to Lu Li, Liu Qin raised his hand and said hello with a smile.
"Dreams!"
When facing Liu Qin, Lu Li was not steely at all, instead he was very active.
Hearing this, Liu Qin's face blushed slightly, pretending not to understand the meaning, and quickly changed the subject, "I only found out after reading the news. It turns out... I haven't seen you in a few years. You are already a world-famous scientist. ."
"It's just a trivial result."
Lu Li humbled and said to Liu Qin, "What about you? Have you graduated from Harvard?"
He knows I went to Harvard to study Ph.D.?
That means...he has been paying attention to me?
Liu Qin felt an inexplicable sweetness in his heart, and said to Lu Li, "I have obtained a PhD, and I am planning to find a job!"
"Looking for a job? With your ability, a lot of units are rushing to ask for it!"
Lu Li slightly touted, and then said: "If there are too many units and don't know how to choose...or come to Fudan as a professor!"
"Come to Fudan as a professor?"
Liu Qin took a look at Lu Li and said, "Does Fudan have any advantages?"
"The advantage is..."
Lu Li pointed his finger at himself, "You can get closer to me, a handsome scientist."
"Cut~! Stinky!"
Liu Qinchao Lu Li rolled his eyes.
They talked and laughed all the way, wandering around Fudan campus.
Then... the Wen Wan girl who was sent a list of books by Lu Li happened to see this scene.
damn it! What's happening here?
Seeing Lu Li talking and laughing with Liu Qin all the way, the corners of her mouth were shaking with anger.
You are so steel in front of me, and you are so humorous in front of her?
If you are with me, just send me the book list. With her, you will make her happy in all kinds of ways?
I...I can't compare to her...
Well, it's really not comparable.
Although deep in her heart she didn't want to admit it, but...in comparison, her appearance was not as perfect as Liu Qin, and her proud and stalwart mind seemed to be one size smaller than Liu Qin.
But... I won't admit defeat! Who is afraid of whom to grab a man by strength?
Wen Wan took a deep breath, with a smile on her face, and walked up to Lu Li and Liu Qin.
"Land from."
Wen Wan greeted Lu Li with a smile on her face, and then walked to Lu Li naturally, very close.
"this is……"
Wen Wan glanced at Liu Qin next to him, pretended to be a mistress, and smiled: "Is this a guest?"
Liu Qin's eyes shrank slightly, and there was an unspeakable complexity in his heart. This kind of hostess's tone... Is she Lu Li's girlfriend?
Lu Li also heard the gentle kiss from the hostess.
Is this intentional? Are you here to demolish my desk on purpose? In that case, don't blame me.
So, Lu Li raised his head and glanced at Wen Wan, with a face full of doubts, "Um...Who are you? Do we know?"
Hearing this, Liu Qin's eyes flashed with brilliance.
But Wen Wan grinned with anger.
I only met half an hour ago, and you sent me a large list of books. Did you pretend that you don’t know?
Bastard!
Dare to do this to me? See how I clean up you!
So Wen Wan pinched her thigh fiercely, and the pain caused her tears to flow down.
Then... looked at Lu Li with a gentle and miserable face, without saying a word, with a heartbroken and weak appearance.
I go! Dramatic!
Fortunately, I am not a vegetarian either!
Lu Li raised his eyes to Wen Wan, and said with a smile: "This girl, the movement of pinching your thigh just now is too big, the flaw is too obvious."
"If you want to pretend to cry in the future, use juice or Fengyoujing. Wipe a little with your fingertips, wipe your eyes, and the tears will come out, which is more concealed."
"Puff!"
Liu Qin beside him couldn't help laughing.
"Asshole! You can find it? Do you have a microscope in your eyes?"
With a gentle grin, she stomped her feet severely, turned and left. Pretending to cry is seen through, and can't play anymore.
"Keen observation, this is a necessary quality for scientific researchers!"
Lu Li waved his hand towards Wen Wan, "Student Wen Wan, remember to read carefully after you go back. You must read the list of books I gave you before. Next time, I will check my homework!"
"Damn the book list!"
With a gentle roar, the pace of fleeing became even more staggering!
After Wen Wan ran away, Liu Qin asked Lu Li, "Is she your student?"
"No!"
Lu Li smiled and replied, "A graduate student from Union Medical College came here to ask me for advice this morning. I think her foundation is not very solid, so I opened her a book list."
consult? Asking is just an excuse!
You even opened her a book list? How steel are you?
But... when you talked to me just now, why didn't you have such steel? It has been expressly implied constantly, it seems that EQ is quite high!
Is it because of me...
Liu Qin's face turned red, but his heart was very happy.
In the next few days, Lu Li took a leave of absence with Professor He and took Liu Qin to play in Shanghai.
Disney, golf, museums, laughter and laughter were left everywhere.
The life simulator is really amazing, with the same girlfriend, you can fall in love countless times!
A few days later, Liu Qin was going back.
"Lu Li, I'm going back. After a few days of playing, my family urged me to go back."
"Then... I'll give it to you!"
Afterwards, Lu left the car and drove Liu Qin to the airport.
Before boarding the plane, Lu Li carried a bag of fruit and handed it to Liu Qin, and said the famous saying: Pear is Li, Lu Li's Li.
...
"Xiao Lu, sent your girlfriend away?"
When Lu Li returned to the laboratory, Professor He "aunt laughed" all over his face.
"Well, sent it back!"
Lu Li nodded, "She is thinking about applying for an economics professor in Fudan. I need to discuss it with my family."
"Oh? Apply for an economics professor?"
Professor He was a little surprised. Could it be that Lu Li's girlfriend is also a schoolmaster?
"She has a PhD in Economics from Harvard. It should be no problem to apply for an economics professor."
Lu Li answered casually, without saying much, "Professor, I'm going to do an experiment."
Harvard PhD in Economics? Returnee doctor?
When Lu Li had just achieved world-renowned achievements, there appeared a returnee doctor with a background of studying abroad?
Out of prudence and protection of Lu Li, Professor He quickly reflected this situation and conducted a political review of Liu Qin.
...
When meeting Liu Qin again, Lu Chengtou was also very happy.
I had another relationship with my girlfriend in reality. This feeling... is really amazing.
It's just... this is still just a dream.
In this plot, falling in love is only incidental, and Lu Li's goal is still very clear. He must find a cure for cancer.
In the next time, in addition to talking on the phone with Liu Qin, Lu Li spent more energy and time in the laboratory.
During the day, the genetic comparison test is conducted in the research institute, and the genetic comparison test is continued through the virtual laboratory at night.
It's just... the progress of this experiment is really frustrating.
The DNA chain has 3 billion base pairs, and it is too much work to compare them one by one and confirm the genetic information.
Even if 10,000 base pairs of genetic information can be determined every day, it would take 300,000 days.
There are three hundred and sixty-five days in a year, and only 36,500 days in a hundred years. Three hundred thousand days...
Lu Li only slightly compared this data, and he felt a deep sense of powerlessness.
What's more, in daily experiments, Lu Li couldn't complete the confirmation of 10,000 base pairs of genetic information.
Can’t go on like this!
Is there any other faster method?
Have!
At present, countries all over the world are studying a new "gene expression" detection tool, which is called a "gene chip".
The sequencing principle of the gene chip is the hybrid sequencing method, that is, the method of nucleic acid sequence determination by hybridizing with a set of nucleic acid probes of known sequence, and the probe of the target nucleotide of known sequence is fixed on the surface of a substrate.
When the fluorescently labeled nucleic acid sequence TATGCAATCTAG in the solution produces a complementary match with the nucleic acid probe at the corresponding position on the gene chip, by determining the position of the probe with the strongest fluorescence intensity, a set of completely complementary probe sequences is obtained. Accordingly, the sequence of the target nucleic acid can be recombined. (Baidu came out, don’t ask me, I don’t understand either)
A gene chip, a microgel integrates countless gene probes, and the speed of "gene expression detection" can be increased countless times.
However, the current gene chip technology has only theoretical research, and the gene chip with real practical value has not yet come out.
But... a theory is enough!
"Virtual Gene Chip!"
With an order, a light flashed, and a huge glass plate appeared in the laboratory. On this glass plate, numerous gene probe arrays are densely integrated.
This is a gene chip.
As long as there is a theoretical basis, the virtual laboratory can produce virtual products.
On the basis of the gene chip, together with optical cables, consoles, computers, electron microscopes, displays and other equipment, it can be combined into a virtual test bench.
After a while, various components were automatically matched to form a huge genetic testing test bed.
Then, Lu Li can perform gene expression testing.
Humans have confirmed that there are 100,000 genes with gene expression information, but... at the base of 3 billion, 100,000 is completely negligible.
Another advantage of the virtual laboratory is that, as long as you think about it, you can get any experimental materials.
So... Lu Li virtualized 3 billion cells missing a certain base pair.
Install these cells in the solution tank, start the genetic testing test bench, and allow these cells with missing base pairs to flow into the gene chip continuously, repeating and comparing.
On the display screen, all kinds of data are surging like a waterfall, and gene expression testing is continuously being carried out.
The solution in the solution tank continues to flow through the gene chip, and it is continuously recovered and circulates without stopping.
This is much easier!
Just wait for the test to be completed and get the final result.
Lu Li sighed for a long time, and put aside the unimaginable amount of repetitive work of genetic testing, and began to study more interesting gene targeting technologies.
At present, in gene editing technology, it is still a matter of luck how to accurately locate and cut the cut protein to the desired position.
If you can interpret all the genes in the human DNA chain and confirm the gene expression information of each base pair, then... it is very important to accurately cut the required gene fragments.
If you can hit the center at one time, you can hit a hundred shots without missing the target, it will undoubtedly increase the efficiency of gene editing technology by thousands of times.
With the existing gene editing technology, gene positioning depends entirely on transcriptase.
Transcriptase is equivalent to a radar. After transcribing the target gene, the transcriptase obtains the target information characteristics, and then scans and searches on the gene chain to compare the target.
After finding the target, the transcriptase combined with the shearing protein will drive the shearing protein to fit the gene chain and cut the target gene.
In theory, this principle is completely correct. It's just that... the "radar" is relatively inefficient, often unable to find the target, or even find the wrong target~EbookFREE.me~ Now, what Lu Li needs to do is how to improve the radar's search ability.
But... it's hard to do!
Transcriptase is a very simple protein molecule, and there is no possibility of updating on the "hardware equipment".
The hardware can't move, the only way is to update the software to improve the resolution.
To improve the resolution ability of transcriptase, it is necessary to master all genetic information on the gene chain.
Well, back to square one.
We can only do gene expression testing first, and first determine the gene expression information of 3 billion base pairs.
Engaging in genetic research depends entirely on how much humans know about genes!
The road ahead is long!
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