Chapter 362: Lu Li, the man who leads the times

Since the gene chip was virtualized, the progress of the experiment has accelerated significantly.
The detection of gene expression information is similar to doing a puzzle. It was very difficult at the beginning. As more and more gene fragments are identified, the speed will become faster and faster.
Seeing the progress of the experiment in the virtual laboratory, Lu Li nodded slightly. According to the current process, the human genetic map should be completed within a few years.
Genetic testing is constantly being carried out, but genetic targeting technology is unable to do anything.
Before completing the human genetic map, it is really difficult to improve gene positioning from software, that is, information accuracy.
Maybe... I have a problem with my thinking.
Since the ability of transcriptase is not good, then change to another one!
When his thoughts were transferred here, Lu Li suddenly understood.
Transcription activators, like effectors (TALEs), are not irreplaceable for their gene targeting specificity in human cells!
There must be other undiscovered "enzymes" that can replace the function of transcriptase.
So Lu Li began to study various cells, bacteria and viruses.
Animal cells, plant cells, bacteria, and even viruses, analyze the cell structure and look for enzymes with gene targeting specificity.
This process is not smooth.
To find enzymes with target specificity in a variety of protein molecules is a matter of luck.
Day by day, enzymes with targeted specificity have still not been discovered.
Liu Qin still came to Fudan. As in reality, Liu Qin became an associate professor at Fudan School of Economics.
Only... the difference from reality is that before Liu Qin joined Fudan, he underwent a strict and detailed political review.
Because when Liu Qin was a Ph.D. student at Harvard, the interpersonal relationship was relatively simple and there was no suspicious social relationship. Moreover, Dad Liu's business is also based in China. He has no foreign assets at all, and he has no business dealings with foreign countries.
So... Liu Qin's political trial is no problem.
When Liu Qin told Lu Li about the political trial, Lu Li looked helpless. It turns out that when I am in a relationship with someone, I still need to go through national review.
The arrival of Liu Qin made Lu Li's weekend time more colorful, and he no longer entered the laboratory every weekend.
Professor He is very pleased with this. Scientists are also humans and cannot regard themselves as machines. Maybe the advent of love can inspire more inspiration.
This... it turned out to be true!
In the second month after Liu Qin joined Fudan, Lu Li's research finally made a crucial breakthrough.
He found another enzyme with target specificity-nickase!
Among Type II restriction enzymes, there is a special type. This enzyme only cuts one strand of double-stranded DNA and creates a nick. This type of restriction enzyme is a nicking enzyme.
From a functional analysis, transcriptase is a large-scale search radar, and nickase is a fire control radar.
In terms of positioning accuracy, the nicking enzyme is indeed very accurate, almost a hundred shots, the problem is...Without a large-scale search radar, it is difficult for the fire control radar to find the target.
That being the case... then combine the two.
So Lu Li began to experiment.
Prepare shearing protein, prepare transcriptase, prepare nickase, and then combine the three organically to form a brand-new gene editing tool.
Next, Lu Li entered the guide RNA on the transcriptase to determine the characteristics of the target gene. Then use the gene gun to inject new gene editing tools into the cells that need to be edited.
Under the electron microscope, the guide RNA on the transcriptase begins to search for the target on the gene strand, and the guide RNA matches the target gene to initially lock the approximate orientation of the target.
Immediately, the sheared protein began to move toward the target position.
When the shearing protein moves to the position of the target, the nick enzyme fire control radar is turned on, and the accurate target is instantly calibrated, and the target is locked!
In the next moment, the sheared protein moves to the target position and begins to fuse with the gene chain, and the spiral gene chain is untied and flattened.
Then... as if with a "click", the sheared protein cut the calibrated position accurately.
A good start! The first experiment was successful!
Subsequently, Lu Li repeated the same experiment hundreds of times, and the results of each experiment were 100% without the slightest error!
It's a success!
The combination of scanning radar and fire control radar allowed Lu Li to create a new gene editing tool.
A revolutionary breakthrough in gene targeting technology!
Since then, human gene editing technology has reached a new level.
The new gene editing tool can accurately lock the target and cut the required gene fragments accurately, no more luck.
Lu Li closed the virtual laboratory, a bright smile appeared on his face.
Gene technology has made another major breakthrough!
Back in the study, Lu Li sat at the computer desk and began to write a paper.
"Gene targeting technology, a brand new gene editing tool."
In the paper, Lu Li described a new gene editing tool with rigorous logic, rigorous expression and detailed experimental data.
In the original gene editing technology of shearing protein + transcriptase, the nicking enzyme "fire control radar" was creatively added, making this brand new gene editing technology have extremely high gene targeting accuracy, and the efficiency of gene editing has become Thousands of times of improvement.
After writing the paper and printing it out, Lu Li walked out of the office with the paper materials.
"Teacher, I have written a new essay, please take a look."
When he came to Professor He's office, Lu Li handed over the thesis materials in his hand.
"New paper? You... have another result?"
Professor He secretly sighed, "It's horrible", and reached out to take the paper that Lu Li handed over.
"Gene targeting technology? A new gene editing tool?"
Seeing the title of the paper, Professor He took a breath of air-conditioning, uh... the air-conditioning from the air conditioner!
Lu Li has come up with a brand new gene editing tool?
Controlling the shock of his heart, Professor He buried his head and looked at the paper materials in his hand.
After reading it carefully, Professor He has clearly seen from the presentation of the paper that a gene editing technology with higher efficiency and greater accuracy has been officially born.
With this new gene editing tool, human gene editing technology has reached a new level.
Lu Li... really is a genius!
First, a brand-new anti-cancer technology was developed, and now a brand-new gene editing tool was developed.
State-owned pillar, the blessing of the community!
Lu Li...will lead the future!
Looking up at Lu Li in front of him, Professor He suppressed his excitement and said to Lu Li, "Go! Let's do a verification."
"Ok!"
With that, the two of them walked out of the office together and into the laboratory.
In the laboratory, Lu Li once again repeated the experimental process in the virtual laboratory, conducting one hundred gene editing experiments in a row.
The success rate is 100%, and the accuracy rate is 100%.
"It's amazing! It's amazing!"
Professor He picked up the laboratory verification data, his hands were shaking, "The efficiency of gene editing has increased thousands of times. This is a revolutionary breakthrough!"
Lu Li smiled.
"this essay……"
Professor He raised his eyes to look at Lu Li, and said seriously: "Delete the specific experimental steps, delete the detailed experimental data, just make the theoretical statement, modify it, and send it to the top international academic journal'Nature'."
After speaking, Professor He looked at the paper in his hand again, and said: "Your current paper, I will submit it to the Chinese Academy of Sciences as an internal document."
"Ok!"
Lu Li agrees with Professor He's "remaining one hand" approach.
Science has no borders, but scientists have nationalities!
We own the latest technological achievements. As for others... I will give you some directions, so let’s do our own research!
Subsequently, Lu Li revised the paper and wrote a directional and theoretical paper. Only... At the end of the paper, Lu Li attached the laboratory's verification conclusion.
After submitting to the "Nature" journal, Lu Li posted his paper on the academic website again.
...
Across the Pacific Ocean.
In the Milliken Genetics Institute, researchers are working intensely and busy.
In the research of genetic technology, the Milliken Genetics Institute has enough self-confidence that they have walked in the forefront of the world.
They proposed the concept of gene chip technology.
The gene editing technology CRISPR-Cas9 was also developed by them.
Although Lu Li's new generation of anti-cancer technology has achieved success, it is only a result of technological application, and the foundation is CRISPR-Cas9 gene editing technology.
It's just... CRISPR-Cas9 technology, the efficiency is still too low!
Inaccurate gene positioning and off-target gene editing require thousands of experiments to obtain a correct specimen.
So... Steven, the chief scientist of the Milliken Genetics Institute, is very dissatisfied with this.
"We are looking for a new gene editing tool. I will solve the funding problem. Even if we spend tens of billions of dollars, we must develop a new gene editing tool within three years. We... want Lead the world!"
At this morning meeting, Dr. Steven’s voice was impassioned.
Then... his speech was interrupted by a scream!
"Omika!"
A man with sparse hair and deep hairline looked at the screen of his mobile phone and exclaimed: "Dr. Steven, you'd better check the academic network first! Someone has already developed this new gene editing tool. !"
"what?"
Dr. Steven was taken aback, quickly took out his mobile phone, opened the academic website, and saw a piece of paper that had sparked heated debate.
"Gene targeting technology, a brand new gene editing tool."
Author...Lu Li!
It's him?
Steven's heart jumped, and he quickly opened the paper and read it.
The paper theoretically describes a new combination of gene editing tools, shearing protein, transcriptase, plus a new "targeted enzyme".
Through the "targeted enzyme" to lock the target, so as to achieve accurate gene editing.
This kind of theoretical papers are actually not of much value. Almost just read them.
However... At the end of the paper, Lu Li even attached a laboratory verification report, confirming that the accuracy of the new gene editing tool was as high as 100%!
This proves that the new gene editing tool developed by Lu Li has been successful!
But...what kind of enzyme is this "targeted enzyme"?
Valco! Why not write down the specific enzyme?
Dr. Steven jumped his feet with anger, slapped his phone on the table with a "pop", and pointed at the man with deep hairline who screamed before, "You, this month's bonus is gone!"
"why?"
The man with deep hairline had a dull face.
"Because... you were playing on your phone when you were in a meeting!"
Well, this reason... is too powerful!
The man with the deep hairline curled his lips slightly, Dr. Steven, you should be irritated, right?
...
Lu Li's paper, which has not yet been officially released, has already caused a violent response in the academic world.
Countless people watched the "targeted enzyme" gritted their teeth. What exactly is the targeted enzyme? You write it out for me!
There are tens of thousands of known enzymes. There are countless variants of each enzyme. If you don't write it, how can we find this targeted enzyme?
Science knows no borders. Why is it so narrow? Announce it! Announce it to me!
...
The next night, on the China TV News Network, another piece of news about Lu Li was broadcast.
"News from this station: After conquering cancer, Dr. Lu Li, a famous scientist in my country, has developed a world-leading scientific research result and created a brand-new gene editing tool. The gene editing accuracy rate is as high as 100% and the gene editing efficiency is improved. Ten thousand times."
"The successful research of this technology indicates that my country has reached the world's leading level in the field of gene editing."
After the news was broadcast, people who watched TV had only one feeling in their hearts, Lu Li again! Lu Li again!
Internet media also followed up immediately, reporting on Lu Li's new technology leading the world.
"Lu Li, the pride of the Chinese people!"
"Leading the world again, cheer for Lu Li!"
"Lu Li created a brand new gene editing technology."
"The great breakthrough of gene technology, Lu Li made gene editing technology take off."
"This man once again leads the world and leads the times!"
On TV~EbookFREE.me~, newspapers and Internet reports, Lu Li just lost his reputation and once again became famous all over the country.
"Your surname is Lu, really 666!"
"Great God, please take my knees!"
"I'm writing a graduation thesis on ‘Imagine the Next Generation of Gene Editing Technology’! You have already researched it. How can I graduate!"
"Sympathize with the wave upstairs. Also... why can't I help laughing out loud?"
"As a scientific researcher in genetics, I am here to talk about the significance of this technology. The emergence of this technology is similar to the invention of the steam engine. Genetic engineering has entered a new era!"
"The next era is the era of genes. Lu Li leads the era of genes for us!"
"Lu Li, the man who leads the times!"
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