Vol 2 Chapter 1261: Finally see the results

   Chapter 1261 Finally see the results
   Just when Zhang Fan and his party were on the plane.
  The Lancet published a heavyweight intestinal tumor paper.
  And it was published by the Tea Vegetarian Hospital. Previously published papers are important to important, but they are not big inventions.
   Either a small new discovery, or an innovation in surgical technology.
  This kind of paper is the accumulation of accumulation. It is helpful for doctors to hire professional titles, but it can't raise the attention of people outside of hepatobiliary disciplines.
  But the intestinal tumor paper published this time is different.
  Maruko Country has been cooperating with Chasu for almost a year.
  From the beginning of the cooperation, the Maruko country first called for the sick from their country. In the first wave, the tea vegetarians were shocked because they found that there were a lot of people bowing on the street.
  Colon cancer is the third most populous cancer in the world, and there are still a lot of people in the country of meatballs. I don’t know if it is a genetic problem or a problem of eating too much sashimi. Even the capital of Yuan Dynasty has this problem.
  It is said that there is a joke, saying that one year the Prime Minister of the Maruko Kingdom reported to the emperor. As a result, after the two-hour report, he first went to the bathroom seven or eight times.
  The emperor was still curious, thinking that the prime minister had taken a fancy to their toilet.
  So, when Wanziguo saw Zhang Fan’s level of surgery on the intestines, he began to work vigorously with the Chasu Hospital.
I originally wanted to seduce Zhang Fan to the Kingdom of Maruko, but after 1980s, the generation that grew up was played over and over again during the time of the tunnel warfare, landmine warfare, and Zhang Ga, the young soldier. It’s definitely not the same as the one who played chess. .
  It is impossible to go to Maruko Country.
  So, Marukoguo can only cooperate with the tea hospital.
  But for medical research, what's expensive is not what is in the laboratory.
   is the cost of clinical trials.
  For example, a new drug needs to be developed.
  This thing, when it was developed, the goal was to target the cardiovascular system.
  First, there are animal experiments in vivo, and there is also a planing experiment.
  But animals can’t communicate with people when playing, they can only observe target organs.
  As a result, when it reaches the human body, the cardiovascular function is too general.
   can make the doctors unexpectedly find that this thing is actually effective on the third leg.
  To be honest, if it didn’t work on the third leg, Weiwei estimated that he would have died in the first round of clinical trials that year.
  Neither of these preliminary trials and R&D are the most expensive.
  It is often expensive to enter the clinical trial stage. Many new drugs die in this area.
  This kind of test first requires a large number of specimens. This kind of specimen is human, so many pharmaceutical companies go to Third Brother for clinical trials.
  It's not that the third brother's clinical trials are awesome, but the medicine is cheap.
  Hundreds of millions or even billions of research and development costs are actually spent on several rounds of clinical trials.
  So, it is too expensive to bring patients from the country of Maruko. Then he encouraged the patients from Outer Mongolia to come over.
  For a while, after the bow was over, a group of similar but different Mongolians appeared on the streets of Chasu.
  The local elder monks took a look, yo, isn’t this the offspring that graze us hundreds of years ago?
  To tell the truth, the Mongolians in China say they are golden, and the outside group used to graze them.
  With a lot of investment, I finally saw the results.
  Colon cancer is prone to disease and metastasis, and the mortality rate is extremely high.
  And this time, the team of Tea Su and Wanzi Guo finally discovered a factor that allows colon cancer to metastasize.
  The scariest thing about cancer is not the growth rate of this thing. According to the current level of surgery, no matter how fast you grow, as long as it is not an important organ, it can actually be cut or embolized.
  But the scary thing about this thing is that it has big long legs, it will run and be contagious.
  It is particularly terrible when it spreads. The first way is lymphatic metastasis. Lymph is originally the immune system. Once it is destroyed by cancer, the body will directly boast.
  Therefore, if the doctor looks and listens, there is one item of touching lymph, especially if the doctor touches your steamed buns. This is not a hooliganism, it is to see if your lymphatic swells.
  Of course, there are scum.
Also, it spreads from blood vessels. Where there is meat, there are blood vessels. Once it enters the blood vessels, there is no chance for surgery. Only radiation and drugs can be used to detoxify. Often the result is that cancer is not killed, drugs and radiation. Hook people up first.
  The third type of direct invasion, such as rectal cancer, why surgery is terrible, because rectal cancer directly invades nearby organs.
  For example, the male prostate, urethra, female genitalia and uterus, the common levator ani muscle, the surrounding skin, and the bladder.
  So radical resection of rectal cancer is quite terrible. It is directly equivalent to digging out all the organs near the chrysanthemum.
  In this kind of surgery, the chrysanthemum looks like a sunflower that has become a big basin. Then all these organs are dug out, and the intestines are directly seen.
  The last one is just like dandelion, planting. After the cancer cells mature, this thing can swim like a dandelion seed in the body, and settle down wherever it falls anyway.
  But what is the reason for the cancer factor to run and metastasize?
  The trouble is that different cancers have different causes of metastasis.
  This time, the team of Tea Su and Wanzi Guo discovered the cause of colon cancer metastasis.
  Creatine!
  Creatine is not only a catalytic enzyme for energy conversion in mammals. It is also an energy buffer.
   To put it simply, for example, you were discovered by your wife for stealing food, and then you start to lie, and your brain runs at a high speed. As a result, ATP is not enough, and ATP is equal to the body’s gasoline.
  This gadget is not easy to store in production, so it is often stored in the form of fat. When it is stored, everyone says it is good, but once it is used, it will be broken down, so when the energy is not enough.
  When the brain is about to go down, creatine is replaced.
  For example, many iron enthusiasts, in order to make the muscles bigger, or to make a turtle shell appear on the belly.
  Replenish creatine.
  Tea Su Hospital discovered this time that for normal people, creatine is good.
  It can be found in colon cancer patients that creatine has a downside.
  This thing can activate the single-stage spindle to cause the Smad2/3 signaling pathway and promote cancer metastasis.
In human terms, the cancer cells originally ate the leek box in the colon. As a result, the creatine was low on hands or had too much energy. It showed its ability to open the space between the intestine and other organs, allowing colon cancer to escape. Highway.
It's that simple.
  What is the fear of disease? What is feared is that I don’t know the mechanism, and I don’t know what this thing is all about.
  Such as SARS back then, why is it so terrible, because it was impossible to study what this thing was.
  But once found, there is always a way.
  Now, although colon cancer has not discovered why it appears, I have discovered how it runs.
  Although this cannot completely eliminate colon cancer, this discovery is already quite powerful.
  If you can cut off the way it runs, even if it has colon cancer, it is still a lamb to be slaughtered. If you are not obedient, the doctor can cut off the intestine with the disease.
  So, this discovery is quite impressive. It can be said that this discovery will directly limit colon cancer to the colon once a drug that inhibits creatine affecting colon cancer is developed.
  After the successful experiment of the Tea Su and Wanzi team, conflicts broke out between the two parties.
  This is whether the so-called coexistence can be the same as wealth.
  Marukoguo means that they are the main force of the experiment.
  Even the money for the test tube was paid by them.
  On the tea side, it is of course impossible for Ren Li to let go.
   quarreled all morning, and finally the two sides compromised.
  Because there are many teams researching this thing around the world, you must post your papers early after success, or you will be spied by the papers to other teams, and you won’t have time to cry.
  Then, the first author is the professor of Marukoku, but the strange thing is that the corresponding author is Zhang Fan, and that's right, Zhang Fan.
  Because there is no leading colon expert and scholar on the tea side. But it was impossible to let go, so Zhang Fan stepped forward.
  Furthermore, because of the previous surgery, Zhang Fan was directly dependent on Zhang Fan. Although Zhang Fan had little effect in the experiment, they could not study without Zhang Fan’s accurate separation of cancer in the early stage.
  So, Zhang Fan became the corresponding author.
  In fact, the first author of a paper is often very important, but the corresponding author is not bad.
  The first author is often the main force of the experiment, the experimenter from beginning to end.
  As for the corresponding author, it is often that he has an idea, perhaps he participated in the experiment or he did not participate in the experiment. Therefore, the general correspondence author is often the teacher or mentor of the first author.
  However, he must be responsible for the experimental results and papers. Fortunately, if there is a problem with the paper, the journal does not contact the first author, but the corresponding author.
  The second author is the one with more weight.
  The rest, third, fourth, fifth and sixth are actually members of the atmosphere group.
  After the paper was published, people from Johnson & Johnson, Roche, Pfizer, and Novartis started to pay attention to them.
  In the past, some research and development equipment focused on tea, but now it’s different. They directly began to put Zhang Fan and the tea hospital in the pool of scholars they focused on.
  After the paper was published, GlaxoSmithKline of Mishima learned that Zhang Fan was coming to Mishima. Originally, they didn't pay much attention.
  Because people are not very prominent in the drug development of the liver.
  Ke people can directly represent the highest level of pharmaceuticals today in terms of breathing, gastrointestinal, metabolism and anti-tumor.
  So, when you see the new discoveries of the tea and meatball country. They started to pay attention.
  The head office directly contacted the Royal Hospital to inquire about Zhang Fan’s itinerary.
  Furthermore, I have to prepare to spend a lot of effort to publicize Zhang Fan.
  Enterprises don’t see blood or knife.
  I don’t see it like that at the Mishima hospital.
  "Do you think Dr. Zhang Fan, who said tea, is suspected of fraud? It is incredible that a hepatobiliary expert can publish a world-class colonic paper."
   "Yes! I can actually become the corresponding author, and the first author is the famous colon professor from Maruko Kingdom!"
  In the Royal Hospital, the director of the Hepatobiliary Department and the professor watched the newly published papers together.
  "Expand the number of participants in the speech. Let gastrointestinal experts also participate." The dean of the Royal Hospital said directly.
   "However, if Zhang Fan really falsified, will it affect our reputation!"
   "No, no, no, if he is faked and is found out by our hospital, it will give us more honor."
  "Okay! Need to invite other countries?"
   "Our Big Three Island Empire, do we need experts from other countries?"
  Professor Royal said proudly.
  (End of this chapter)