Chapter 91: Prion

　　　　 Then Zhou Wen spent 200 points to learn the formula of biological wrinkle cream.
　　 Zhou Wen checked it, and it was not bad. As expected, it is also necessary to purchase a special biological enzyme additive from the system store.
　　 Let's keep this for now.
　　 After calming down, Zhou Wen thought about it a little bit and upgraded his pathology to LV2.
　　 Pathology and pharmacology are complementary to each other. From the perspective of pharmacy, only by knowing more about the causes, mechanisms, development rules, and the morphological structure of the body during the disease process can we better study drugs.
　　 With the upgrading of [Pathology], a lot of knowledge poured into Zhou Wen's brain.
　　 The pathology knowledge stored in the brain quickly became alive.
　　 once knew only one thing, and did not know the other, now I have a deeper understanding.
　　 Combined with pharmacology, he really has become a brilliant doctor now.
　　 and a general practitioner.
　　 He understood the causes and treatment options of most conventional diseases.
　　 such as inflammation, cardiovascular disease, respiratory disease, digestive system disease, lymphohematopoietic system disease, immune disease, urinary system disease, etc.
　　 Zhou Wen was so excited that he almost didn't jump up.
　　 It may be difficult for outsiders to understand his current mood.
　　 is like a scumbag who knows the content of the college entrance examination in advance, then memorizes all the knowledge points and the answers in advance, and waits for the counterattack in life. What is it like?
　　 It's so cool.
　　 And Zhou Wen "remembered" more than the answer to the college entrance examination, he even "remembered" the answer to the university exam.
　　 This feeling of taking shortcuts in life has made Zhou Wen's 360 pores unfold.
　　 Now he wants to find someone and show him his illness, such as orthopedics...
　　 Sunday morning.
　　 It may be the reason why it rained yesterday. The weather today is exceptionally good. The fiery red sun rose from the horizon early, scorching the earth, and the air gradually began to heat up.
　　 At eight o'clock in the morning, Zhou Wen took a bus to Tianhai Intellectual Property Agency Co., Ltd. on Jianghai Road.
　　 I met the general manager Meng Xiang in the office.
　　 Meng Xiang is very young, only in his early 30s. He is straightforward, wearing a red striped shirt + black trousers, and a pair of gold-rimmed glasses on the bridge of his nose. His temperament is elegant and he looks like a Kochi.
　　 "Hello, Mr. Zhou~"
　　 "Hello Manager Meng."
　　 The two exchanged simple greetings, and then took their seats separately.
　　 Zhou Wen took out the printed patent application specification from the computer bag, "Mr. Meng, take a look."
　　 "Okay." Meng Xiang took the thick stack of instructions, pushed the frame on the bridge of the nose with his middle finger, and then turned to the first page to read it.
　　 Meng Xiang looked quickly, with ten lines at a glance.
　　 Like those process flow diagrams, formulas, etc., skip it directly.
　　 35,000 words, plus picture formulas, etc., totaling nearly 30 pages, and Meng Xiang saw the end in five minutes.
　　 When those things are turned around, someone will naturally review them one by one. What he needs to know is, what exactly is the patent specification of such a long length?
　　 Where is it awesome?
　　 "Product effect description: After the refinement and improvement of this process, the effect of the powerful version of sildenafil tablets will be increased by 200%~300% on the original basis."
　　 Meng Xiang: "…………"
　　 Meng Xiang felt speechless.
　　 He doesn't know what to say.
　　 Looking at the face of the classmate who is the baby's daughter of the chairman, he rushed to the company and waited for the other party for more than an hour on Sundays, but what he waited for was the prescription of this fairy tale...the process flow.
　　What international joke?
　　Who do you think you are, and improve sildenafil?
　　Pfizer Pharmaceuticals of the United States, after discovering the effect of sildenafil in the treatment of ED in the early 1990s, hundreds of pharmaceutical engineers have invested in research and development.
　　The process flow has already gone through thousands of trials.
　　 You just say that you have improved the process of others, and the effect has increased by 200%~300%.
　　 Are you too dear to yourself, or do you despise Pfizer's pharmaceutical engineers too much?
　　 "Ahem~" Meng Xiang coughed and said, "Well, Mr. Zhou...I don't think it is necessary to apply for this patent."
　　 Zhou Wen wondered: "Why?"
　　 Meng Xiang stretched out his hand to push down the frame, and said euphemistically: "I think it's impossible for this process to be patented.
　　 You have to know that it took Pfizer nearly 10 years to develop sildenafil, and the process has gone through 20 years of continuous improvement after the market. It cannot be surpassed casually. "
　　 Zhou Wen smiled.
　　 There is no clinical trial result, anyone who reads this patent application description will think it is a fantasy.
　　 He did not argue, and said with a smile: "What Manager Meng said is, but I still want to register a patent."
　　 Meng Xiang knew that a person who could write a 35,000-word patent application specification could not dispel the idea of ​​registering a patent with just a few sentences, so he did not try to persuade him.
　　 "Since you insist, do as you say."
　　 Zhou Wen asked: "What about the cost?"
　　 Meng Xiang thought for a while and said, "To be honest, if you calculate according to the value in your patent specification, the agency fee is very expensive, but you...
　　Let’s do it, add all the expenses together, you can give a total of 150,000. "
　　 "150,000... or a friendly price, these top agencies are really expensive."
　　 Zhou Wen secretly said something in his heart, and asked: "Do you think this will work, I will pay 10,000 yuan first, and the rest will be paid later?"
　　 Meng Xiang nodded, "Yes."
　　 Then the two parties signed an agency agreement, and Zhou Wen gave the copy of his ID card to Meng Xiang.
　　 After that, Alipay transferred 10,000 yuan to Tianhai’s company account.
　　 Even if the agency matters are settled.
　　 The rest is handled by Tianhai Office. He just needs to wait for the patent certificate.
　　 Zhou Wen got up and said goodbye.
　　 Meng Xiang kept sending him to the elevator entrance, and then turned back to the office after watching the elevator go down.
　　 picked up the phone on the way and dialed out.
　　 "Hey, miss, it's already done... his patent... a total of 150,000..."
　　 Meng Xiang just said the price, and suddenly there was a roar on the phone, "What, 150,000, so much?"
　　 Meng Xiang smiled bitterly: "This price is already very cheap. If calculated according to the market price, at least 1 million agency fees."
　　 "You don't want to be so dark-hearted, OK? How can he have so much money? And you said that it is impossible to succeed, so why bother to cheat other people's money... just 10,000."
　　 "I didn't pit him money... and the contract has already been signed, it's hard to change."
　　 "Then I don't care, you can figure it out."
　　 "I...dududu..." Just as Meng Xiang was about to speak, the phone was hung up.
　　 Meng Xiang looked at the hung-up cell phone, and said depressed:
It’s true that girls turn their elbows outward. UU reading www.uukanshu.com must never give birth to a daughter.

　　……
　　 As soon as Zhou Wen arrived downstairs, he received a call from Yang Liqun and asked him to visit the testing center.
　　 Zhou Wen hurried to the testing center.
　　 Yang Liqun handed over an electrophoresis test report, "Look at it."
　　 "What's the matter?" Zhou Wen took it and took a look, and found that it was a very rare "prion".
　　 The knowledge of prions quickly emerged in Zhou Wen's brain.
　　 Strictly speaking, "prion" is not a virus. It is a toxic biological molecule that only contains protein and no "nucleic acid", so it is also called "prion protein".
　　 prions are currently recognized as a misfolded protein in the world, and there is no accepted conclusion about its three-dimensional structure.
　　As a self-replicating peptide chain, prion protein may be a biological molecule older than the nucleic acid chain.
　　 may have been due to an accidental "amino acid combination" that gave it the original characteristics of life such as "duplication".
　　 Although it is not a virus, the horror of prions is not inferior to viruses, and even worse.
　　 The famous "mad cow disease" (CJJD) is caused by prions.
　　 Many neurological diseases, such as "Alzheimer's disease" and "Parkinson's disease", are inextricably linked to prions.
　　 The clinical manifestations of this type of disease generally include central nervous system diseases such as dyskinesia, tremor (hand shaking), postural instability, dementia, hypersensitivity, and abnormal behavior.
　　 Yang Liqun said: "The clinical manifestations of this case are very special, and he often laughs uncontrollably..."
　　
　　Ps: Sorry, please...