Chapter 179: Correct technical route

Li Hao also listened to the explanation given by Director Du Xianyu. At the same time, he and the real technology and the alien technology he had learned at the same time confirmed each other.
It is known that most of the front-end technologies have now been completed in organ manufacturing technology. The final challenge will be carried out. He expected the technology to be completed much earlier.
It was expected to solve the problem of organ manufacturing in two years, and it was very fast.
After the laboratory broke through the first core technology, he expected it to be completed within a year. It now appears that the entire organ will have to wait a long time. However, some functional cells have met the needs of clinical validation.
Li Hao smiled on his face, and hurriedly asked Du Xianyu: "Director Du, you have successfully completed hematopoietic stem cells. Can you treat diseases such as leukemia, hemophilia, and lymphoma?"
If hematopoietic stem cells are developed, they can solve the terminal illness that has plagued humans for many years. The impact of that is really too great.
Director Du Xianyu shook his head and said, "This is our future goal. There are still many technologies that are not mature, but the technology for making blood and blood products is mature."
Li Hao immediately extracted the key points of Chairman Du Xianyu's speech. He then asked: "Director Du, you mean that our company's technology is not mature yet, not that the technology has not yet been developed. Does that mean that the technology has been developed?"
Du Xianyu said helplessly: "We have induced and differentiated hematopoietic stem cells, and various technologies have been successful.
We have done experiments in mice that have been genetically knocked out to make them have hemophilia. The feasibility of hematopoietic stem cell therapy has been proven.
But its mortality rate is very high, reaching 60%. Such a high mortality rate cannot be used in clinical trials.
Without addressing the specific cause of death, we will continue with animal experiments. "
While listening to them, Zhou Yunsheng reminded: "Director Du, the cure rate of 40% is already very high for this disease. Without this technology, the mortality rate is 100%.
And your laboratory animals, is it the death caused by the injection of hematopoietic stem cells or the disease. These two points need to be made clear, and their meanings are different. "
"Zhou is assured that the medical expert group of our project analyzes the pathological changes of experimental animals at all times. We will not notice if we find out." Du Xianyu replied with a smile.
Li Hao realized that the mortality rate of this technology should not be so high. He asked directly: "Director Du, what caused the death of the mice is mainly caused by the introduction of human hematopoietic stem cells into mice, and its mortality is not so high."
"Immune rejection, there is really no way. We have knocked out the surface antigen of hematopoietic stem cells. But for some unknown reasons, it will also cause the organism's immune system to attack." Du Xianyu said helplessly.
After hearing this result, Li Hao opened his eyes wide and asked, "You guys knocked out the surface antibodies of hematopoietic stem cells. Why don't you use mouse cells to culture hematopoietic stem cells, and then conduct experiments later."
"Our project is organ manufacturing and industrial production of organs. Our goal is to solve immune rejection. Like producing industrial products, we produce exactly the same organs for human transplantation.
President Li, this is not what you ask of our biological laboratory. We have been working in this direction. "Director Du Xianyu said very firmly.
In the sight of Zhou Yunsheng's fools, Li Hao covered his face and smiled bitterly. He should have inspected Director Du's technical route long ago. I did not expect such a big mistake.
You should know that Du Xianyu is a typical persistent personality. That was to study the technology of human cloning, and to explore the technology at the risk of breaking the law.
He could only explain with a bitter smile: "Director Du, you have misunderstood what I meant. I am talking about the ultimate goal of the project. But now we have a very shallow understanding of life sciences, and we have only explored the immune function of the human body to the primary stage .
We can't knock out all the proteins on the cell surface, so the cells can't perform functional tasks. In particular, we lack the overall knowledge of the immune system, and we still cannot completely eliminate immune rejection.
The best technical route now is to choose the general of the recipient itself and cultivate it into a complete organ. This way we don't need to consider immune rejection. "
Du Xianyu thought about it for a while, and said, "This method requires targeting each different receptor, cultivating his cells from scratch and inducing differentiation.
This process is easy to complete in our laboratory, but it will definitely be applied in the future.
The science and technology workers in our project team also conduct their own project research and development. It is impossible for me to treat professionals as workers for such low-quality work.
We also can't give this work to others. Every step requires experienced personnel, and there is really someone who can do this project. Then he is an excellent research assistant, doing such repetitive work is a waste of talent. "
Li Hao directly asked the most critical question: "Director Du, I said that the use of specific human cells to cultivate organs and some functional cells, can the current technical standards meet the requirements. What can happen when they are implanted in patients ?
Is the average person over it, what is the worst result? "
Du Xianyu didn't think much, and immediately answered the question: "We are now only inducing the differentiation of hematopoietic stem cells, such as the use of receptor-induced cells to differentiate into hematopoietic stem cells.
I can be sure he won't show rejection. It also means that it has no impact on human safety. But whether it can divide and differentiate normally in the body. Since I haven't done any experiments, I can't determine the specific effect.
But our experiments on mice did not interfere with other related diseases as long as the metabolism was normal. When cells are implanted in the body, they work normally. "
After answering this question, he went on to say: "It is better to use only ordinary people to operate the whole process, and let the machine operate the process according to the intelligent program.
Without professional intervention, its success rate is very low. We can only reach ~ EbookFREE.me after testing. After testing for hematopoietic stem cells, it can differentiate into deformed cells or organs that look normal but have no effect on the surface. There is also no biological activity.
We reject this technical route because the detection process is too cumbersome. Until a good detection method is found, this technique has many disadvantages.
Some even had no problems after testing. But when transplanted into living organisms, they were unable to exert biological activity.
If the appearance is bright, the organs that have no effect will be transplanted into the patient. Like hematopoietic stem cells, this is not a medical accident for large organs. "
Li Hao heard from Director Du Xianyu that he finally knew where the technical difficulties of their work were.
But he still felt that his technical route was more correct. The universal organs recorded in the library, their implementation method is very difficult for the current scientific and technological foundation.
Li Hao put forward his own suggestion: "Director Du, I think using specific human cells and using instruments to synthesize target organs. This technical route is easier to implement.
With your ability to find a biochemical test method, it is easier to make a universal organ. "
Du Xianyu also felt that Li Hao was right. He pondered for a while and responded, "Then I will redistribute the scientific research power of various project groups. Our main people will continue to explore the culture and differentiation of totipotent stem cells.
It just makes the medical team and the organ testing project team to explore better ways of detecting biologically active organisms.
As for the study of general-purpose organs, only a few scientific research groups are reserved for exploring the technical feasibility. "
Li Hao gave a thumbs up and sighed: "Director Du's method is very good, and everything is arranged well. I just make suggestions. You are an expert in this field and arrange it according to the specific situation of the project."