Chapter 514: The mystery of aging, the MTOR gene signaling pathway!

Luo Luojia picked up the ink pen that had been prepared, wrote on the whiteboard in the conference room, and wrote down many complex and mysterious codes. The Wen brothers glanced at them and knew that they were genetic codes.
On the other side, Wen Chengfeng cleared his throat and began to summarize the recent work of the Department of Life Sciences. Luo Jia showed great trust in them and never urged the progress of the research. He did not even inspect it every few months. The second Luo Jia has come, always report to the boss, this is also human nature.
"In the past six months, the biggest research achievement of the Department of Life Science is to clarify some issues related to human life. First of all, can humans live long?"
Wen Chengfeng glanced at Luo Jia, "The answer is yes, of course, human beings may have a long life span, because it is well known that our body cells are undergoing metabolism every moment."
"Take the superficial skin that women are most concerned about, it takes 14 days from birth to death for keratinocytes. If you count the 13 to 19 days of the division cycle, the entire cycle of skin metabolism is 41 to Forty-seven days. "
"According to different ages, there will be a difference in the speed of metabolism. Young people have a short metabolic cycle, and older people have a longer metabolic cycle."
也就是说 "In other words, it only takes a maximum of forty-seven days, our face is no longer the face of the past, but a new face is replaced by the way of cell metabolism."
"Of course, cell-level metabolism is a micro-level change. From the outside, it seems that everything is still the same. However, the cells that make up the facial epidermis have been replaced with a new batch compared to 47 days ago. This is beyond doubt. fact."
Luo Luojia nodded slightly. Human beings are composed of cells. Cell replacement takes place every moment. From the perspective of cells, yesterday's you and today's you are actually different.
Wen Chengfeng continued: "The life span of liver cells is only five months, and even if they die, they will be replaced. Even our bones will complete a round of cell replacement every ten years. After middle age, the rate of bone regeneration slows down. As a result, osteoporosis has formed, so it is easy for elderly people to break after wrestling. The root cause is not that the bones become weaker, but that our elderly people's metabolism has slowed down. /
由此 "It can be seen that if we can control the rate of metabolism, it is equivalent to turning on the code of life span, and human metabolism is controlled by genes. What we are doing is to find and control that set of genes about life span."
"At present, the only way we can determine the correct way to open longevity is called energy restriction. In short, it means to eat less and to be full every time we eat."
"We tested on humans, on mice, on cells, and on almost all species. By controlling diet and reducing calorie intake, we all succeeded ..."
Wen Chengfeng introduced a lot to Luo Jia. From the past to the present, nothing has happened. When he said that the laboratory established 18 standards for aging, Luo Jia focused on and felt that he had given the Department of Life Science to the Wen brothers. It was an extremely correct decision.
Science is not a child's play. It requires strict and quantifiable standards.
Luo Luojia has forgotten to see in which online novel, the novel mentions a kind of technology, Yanshou Technology, how to extend life? Anyway, it makes people look young.
looks young…
Hey, Luo Jia is really powerless to speak about this idealistic subjective description.
The specific items set by the Wen family brothers include the following items:
1 glycoprotein.
2 Forced breathing volume within one second.
3 arterial blood pressure.
4 total cholesterol.
5 reactive protein.
6 creatinine clearance.
7 urea nitrogen.
8 Cardiopulmonary fitness.
9 waist-hip ratio.
10 maximum vital capacity ratio.
11 Body Mass Index.
12 white blood cell telomere length.
13 lipoprotein.
14 triglycerides.
15 periodontitis.
16 white blood cell count.
17 high density lipoprotein.
18 Apolipoprotein ratio.
This is the correct attitude to science. In order to study anti-aging, they first used eighteen rigorous data to define what aging is. Along with this standard, a set of algorithms and mathematical models were used to input personal indicators. , You can get the current aging coefficient.
"This is the current status of research in the Department of Life Sciences." Wen Chengfeng concluded: "We have done a lot of research, defined the standards of aging, and found some organ-level metabolism control technologies, such as our metabolism management of the superficial skin. It has achieved quite good results. The company's cosmetics department has swept the world, and it has made an amazing amount of wealth from female consumers who love beauty, and these wealth eventually turned into space elevators and became our department's research funding. "
"To be honest, I was a bit scared. In order to smooth out a few crow's feet in the eyes, women are willing to pay such a high price? This is not scientific! Is it just a few wrinkles, why are they so active?"
After listening to Wen Chengfeng's spit, Luo Jia almost laughed out. The company was so serious that the straight male spirit was up and down. The Wen brothers are all in their forties and they are not too young. They can still be completely confused.
Not scientific?
什么 When has a creature like a woman been scientific?
Luo Luojia coughed twice, stood up, and came to the whiteboard, "I have already understood the specific situation, the Department of Life Science has done a good job. In short, I am assured of you 120."
"Next, I want to talk about my discovery in my spare time. Since distributed supercomputing and artificial intelligence, the threshold of scientific research has been greatly reduced. Not only can I build my own model, do gene deduction, or even genetic science. Some junior high school students and elementary school students who have some knowledge can also engage in research of their own interest, and simulate the evolution of genes and the path of effect on supercomputing. "
Huaxia's distributed supercomputing system is now getting more and more aggressive. The nationwide network and computing power are climbing wildly to the point where it is open to all individual users. Any Huaxia citizen can use supercomputing resources to engage in scientific research.
Of course, there is still a big gap between ideals and reality. According to statistics from the Supercomputing Authority, the largest application of the Huaxia distributed supercomputing system is game computing, and the second place is CG rendering.
In other words, everyone did not do learning, but used supercomputing resources to develop games and post-rendering for movies and anime, so that the pictures of small movies were more clear and moving, and the sound was more trembling.
Luo Luojia didn't object to the game. He didn't play the game less often. The key is that the game needs to be graded and restricted. As long as young people don't indulge in it and play for two hours a day, Luo Jia doesn't object.
As for the small movie becoming clearer, Luo Jia didn't say it. In fact, he secretly clicked a like. HD small movie with panoramic VR is a good thing. Whoever sees knows.
Luo Jia explained to the Wen brothers that he was engaged in life science research in his spare time, and he would come up with some scary conclusions. You do n’t have to doubt. It ’s not that I have anything special. Luo Jia has always been careful about the truth.
Luo Luojia pointed to a line he had written on the white board earlier: "mammaliantargetofrapamycin, mammalian rapamycin target, MTOR for short."
"MTOR is a type of threonine kinase, the C-terminus is homologous to phosphatidylinositol kinase, but it does not have esterase kinase activity, but protein kinase activity. I deduced MTOR through supercomputing and found that Some very strange phenomena, it seems that the gene signal pathway of MTOR has the function of controlling substance metabolism and cell autophagy. "New 81 中文 网 The fastest mobile phone update: https: /
After listening to Luo Jia's opening, the Wen brothers explained for a moment, striving for 12 points.
"Impossible! Could it be said that Luo always found a gene pathway that controls metabolism and cellular autophagy !?"
The Wen brothers were screaming in their hearts, and they were all shocked. The gene signaling pathway was actually nothing new. Scientists discovered it as early as 1972.
In simple terms, it is through protein kinases and phosphatases as signal-transmitting substances, and finally gives orders to the cells, telling the cells that you should divide and proliferate, you are already senile, don't stand in the pit and don't shit, hurry to self-calculate balls, etc. .
You can order your child to wash your hands before eating, but you ca n’t order your child to grow taller quickly, at least 1.8 meters long, and have charming little eyes and long legs like South Korea ’s Ouba.
However, the gene signaling pathway can do it, because it can directly give orders to the cells. The tens of billions of billions of cells are the most basic unit of the human body. Changes in cells will eventually lead to global changes.
Since the gene signaling pathway is so great, why don't we try to write human genes to stop aging and let everyone grow long legs?
The reason is very simple, it is too difficult.
The human gene map has 25,000 genes and 3 billion bases. The number is too large.
However, if you think this is all about human genes, you can only say that you are still too naive.
In addition to the above, there are more than one million bacterial genes in the human body, because there are about one trillion billion cells of other organisms in the human body.
In other words, 90% of the cells in our body do not belong to ourselves. Our body is actually composed of bacterial flora and some human cells attached to it.
During billions of years of evolution, our body cells and trillions of microorganisms have been in symbiosis. Microorganisms have affected the evolution of each of our organs, including the brain and heart, and the DNA of microorganisms has already penetrated into human DNA. The DNA of microorganisms has already become a part of human DNA!
Some people say that human beings are the most complicated beings in nature. From a genetic perspective, this statement is correct.
Human genes are really complicated, and it is almost impossible to find a path to completely control aging in such a complicated gene sequence, EbookFREE.me, even a developed extraterrestrial civilization cannot.
The MTOR pathway provided by Lan Yu to Luo Jia is not a complete life control, but a certain degree of control of metabolism and cell autophagy. The 2016 Nobel Prize in Bio and Medicine was awarded to the principle of cell autophagy. The discoverer, it can be seen that the research of the Earth people in the field of genes is just in its infancy.
However, Luo Jia came to the Wen brothers' laboratory to bring them a gene signal pathway that can control metabolism and cell autophagy, which made Wen brothers tremble with excitement!
They can't believe what kind of luck is to make Luo Jia accidentally find a gene signal pathway controlled by aging in her spare time when doing genetic calculations! ?
After the introduction, the Wen family brothers were stunned. Luo Jia lowered the pen slightly and shrugged. "I am a layman on issues in the field of life sciences, but according to the results of the supercomputing model, it seems that the gene signal pathway of MTOR "It may ultimately control the rate of cell metabolism and trigger cell autophagy."
"I wondered, if all the aging cells in the body were renewed through the principle of autophagy, wouldn't it be equivalent to washing the spine and regenerating the bones in the martial arts novels? It seems like it's very messy, otherwise you follow this Genetic pathways, a little experiment? "
After hearing Luo Jia's remarks, the brothers of the Wen family stared with wide eyes.
Do you have a problem?
If Luo Jia's model is deduced correctly, the MTOR signal path has more than just gotten into trouble, that's a big deal!