Chapter 363: Don't grind, fuck!

Scientific research is also a carnival chasing hot spots.
This is how Li Zheng talked with Zhou Yi and Shi Yang at lunch.
Outsiders don’t care, but for those inside, especially those in the biosphere, cryo-EM has been a super hot spot that has been chasing for many years.
With the Nobel Prize for cryo-electron microscopy technology three years ago, this hot spot has reached its peak.
In human terms, the biggest feature of this technology is that it can easily and easily obtain three-dimensional holographic images of macromolecular structures, thereby completely "wiping out" structural biology, just as point-and-shoot cameras "wiping out" old-fashioned film studios.
In the face of this attractive technology, domestic universities immediately followed up to introduce cryo-electron microscopy. The initial feeling was as sacred as welcoming the "lithography machine". Whether to have its own cryo-electron microscope has become a measure of whether the Institute of Biology Top core indicators.
In recent years, with the decline in the price of cryo-electron microscopes, although this equipment is not so sacred, it is still a big money-burning guy.
The acquisition cost of 5 million to tens of millions of yuan may not seem so exaggerated, but one such equipment often requires several operation and maintenance personnel, and is a researcher with top education and mastering this technology.
Scientific research is an event that does not necessarily have results, but the burning of money is everywhere in it.
There are only two such equipment, even Jida, a high-end version of the living room, and a relatively early normal version in the chemical institute.
Because of its scarce characteristics, it is necessary to make an appointment before use, and the appointment time is accurate to the hour. If several groups make an appointment at the same time, then it is often only dependent on the subjective judgment of the hospital leaders.
According to Zhou Yi, it is basically impossible for Li Zheng's group to use the high-end cryo-electron microscope of the Shengyuan Hospital. There is hope for him to apply for this one in the Institute of Chemistry, but it will not be used for too long. It must be used under the supervision and guidance of operation and maintenance personnel.
Unintentionally, this also led to a dilemma in domestic scientific research.
To come up with results, you must buy high-end equipment.
It takes a lot of money to buy high-end equipment, but the total budget is limited, and more money will give units with better past results.
Ordinary units have no money, so they can't afford the equipment and cannot produce results.
To come up with results, you have to buy high-end equipment...
In addition to this cycle, the advantages of studying abroad have indeed been revealed.
In some developed countries, such equipment is not too expensive or scarce. It can be frequently accessed during graduate school.
On the contrary, even in Ji University, most graduate students in related fields don't even have the opportunity to see such equipment from a distance.
This layer of logic is like a doll, which in turn connects to the dilemma of biochemical materials.
Top-notch biochemical graduate students who are proficient in using technologies like cryo-electron microscopy are unlikely to find a job. Major universities are rushing to send the staff.
But most of the remaining ones often have few chances to touch them. They are trapped in low-tech mechanical repeated experiments all day long. In the complicated and exhausting subjects, those ideals that change the world are gradually obliterated.
In the dining room, Zhou Yi finally sighed against the back of his chair.
"Hey, the situation is much better now. When the equipment was first introduced, in order to grab a researcher who has experience in using cryo-electron microscopy abroad, several major domestic colleges and universities were eager to send a house, and now just send a household registration..."
"Oh?" Shi Yang's frantic hand stopped suddenly, chewed and swallowed, and asked cheerfully, "Then Old Zhou, if I mix up for a while, is there a bunch of colleges who want to dig me?"
"Generally." Zhou Yi sighed with a smile, "You may think that if I just say a few words, you can engage in cryo-electron microscopy, but this feeling is one-sided. In fact, the reason why the subject is so smooth, I This support is because you have already proven yourself in your studies and proved that you are one of the top talents in one million, one in 100,000, and one in a million. If you don’t have this level of understanding, you will have graduated from graduate school. There may not necessarily be such an opportunity."
"I believe this." Shi Yang said to Li Zhengnu. "Boss Zhou is really interesting. It has always been. As long as I perform enough, Boss Zhou will give me any resources."
Li Zheng immediately raised his teacup: "Yes, I don't know how to thank Teacher Zhou anymore, try to speak with the results."
"Just do your best." Zhou Yi toasted and laughed. "Although this topic is very interesting, I don't really look forward to it too much. Don't have pressure. Exercise is the focus. It's not bad to have an experimental report that can be read. Don't fail. To the bottom of my heart, my request is just one point-don't break the machine!"
"Speaking of machines..." After taking a sip of tea, Li Zheng slowly lowered the cup, frowning slightly, "Is it that expensive?"
Zhou Yi said, "No way, domestically produced ones are not there yet, and they are unlikely to be available in five years. Most high-end instruments are in this situation."
"Where is the technical difficulty?" Li Zheng asked subconsciously.
"This is not my major anymore. The teachers of the College of Science and Engineering should know a little bit about it." Zhou Yihuang's hands fell and the index fell, "If you do one thing well, think about the next one. Don't come to this with me. , Da Vinci didn’t work with the manufacturing of these sophisticated instruments. Just give me the whole experiment and don’t let my mind go too far."
"Yes, it's pure curiosity." Li Zheng laughed.
If it weren't for the learner system to be identified as a user impaired, he was afraid that he had already opened the engineering interface to study it.
...
On the other side, Teacher Zhou Xiao, who was very interested in Li Zheng's group's topics at the inquiry meeting, also ran directly to the School of Health and found the old classmate who had been the head teacher together.
It was also a simple meal in the canteen. After Zhou Xiao explained the situation, the old classmate put down his chopsticks and explained it to Zhou Xiao.
"Zhou'er, this is how you do..."
"Want to push it down is not a matter of process."
"There must be a heavyweight platform."
"Either you, Dean Niu Gang, go to our dean directly."
"Either persuade Professor Bing from our college to let her do her best."
"Scientific research is like this. In the end, it is a resource dispute between several big bosses."
"The cryo-electron microscope is our most urgent resource."
"Zhang Shandong's judgment is correct, there is nothing wrong with it, let's not get into this matter."
"Especially if a few undergraduates are fooling around, and if they cause accidents or equipment damage, they will be punished. It is not that the students will be punished, it is us."
"You listen to me, leave it alone, it's useless."
When Zhou Xiao heard that the food tasted tasteless, he put down his chopsticks and wiped his mouth.
"I just think... this subject is really done."
"Also, Li Zheng's level cannot be measured by the average person's level."
"Take a step back, he can touch the tens of billions of Yellow River No. 2, but he can't touch the tens of millions of electron microscopes?"
"At this point, the letter of recommendation from Lao Aerospace is very telling."
"How much is the recommendation letter worth?" The old classmate laughed, "What's the matter, the people who pulled their space system to blame?"
"Li Zheng's level will not happen."
"Do you dare to pack tickets?"
"I dare."
"Well, even if you dare, and the leader believes, give you a chance to take responsibility, but what if there is nothing wrong?" The old classmate slapped his palms, "not counting the purchase price, you know that such a frozen electron microscope What is the maintenance cost?"
"How many?"
"I don't know, but I just look at the operation and maintenance lineup and the consumables that come in and out. They have to eat at least tens of thousands a day. Li Zheng and the others take up resources like this. Let alone how much money they burnt, and delay other issues. How does the time count? Who is not racing against time? Who is not behind the big boss platform?"
"..."
"Mature, Zhou Er." The old classmate patted Zhou Xiao and said, "I know that you are going to teach in Yingpei. You really agree with that philosophy. I really want to make a name, but we can't commit a personal risk. Fire is not."
"What's the risk? What's so evil." Zhou Xiaoqiang smiled and pushed his old classmate away. "Serving students is my duty. I didn't think about how big things I would do. I just think Zhang Shandong should at least report the situation to Niu. Dean, we are not qualified to judge subjects of this level and should be handed over to the dean."
"Heh." The old classmate waved his hand and smiled, "I don't know how Dean Niu reacted. Anyway, if you do this, Zhang Shandong won't hate you, and maybe Dean Niu would have known it a long time ago. Deliberately pretending not to know."
"Why do you deliberately pretend not to know?" Zhou Xiao asked incomprehensibly, "Our Dean Niu is not that kind of person!"
"Hey..." The old classmate shook his head and got up, "You are not too young, you are lacking in a root..."
Zhou Xiao followed and got up: "No...we are teachers, are you making things complicated?"
"Things are very simple, talents are complicated, and people's places are naturally complicated. This has nothing to do with identity and work." The old classmate picked up the dinner plate and nodded with a smile. "But you have always been this kind of unhearted virtue, whatever you want. Well, I'm just talking about greasy experience, not necessarily right."
The old classmate left, and Zhou Xiao stood in the bustling cafeteria, his thoughts turned into a mess like those leftovers.
He intended to find out about the situation, and then went to Dean Niu to report.
But now, he became uncertain.
In confusion, the phone rang.
"Hey……"
"Yes, the canteen, Director Zhang."
"Business trip?"
"Oh... well, no problem."
"Okay, I'll find him right away..."
Putting down the phone, Zhou Xiao sighed, and after repeated corrections for a long time, he sent a text message.
[Li Zheng, this is Zhou Xiao, Zhou Xiao at the inquiry meeting. 】
[I have asked the School of Biology, but it is difficult to obtain equipment conditions. 】
[I also suggest that you start some topics that require relatively low resources. 】
[If you must persist, I am afraid that you can only use your personal resources. 】
[I am going on a business trip for two months recently. Whether it is persisting or starting a new question, you can find me for any questions. 】
After sending it, and before putting away the phone, Li Zheng answered it in seconds.
[Thank you, Teacher Zhou, what you did is right, I have my method, you don’t have to regret it. 】
[You must be a good teacher. 】
[Li Zheng. 】
Seeing this reply, Zhou Xiao finally squeezed a smile.
About this sentence, I stayed in school.
...
Zhou Yi not only looks like a Wangzi, but he is also very prosperous in doing things. He has finalized the experiment in just three days.
From September 8th, one week, 7-11 o'clock every night, 4 hours of usage rights, plus some consumables.
There are only 28 hours a week, which is undoubtedly a far cry from the 45 days he initially judged, but according to his intentions, as long as the experiment goes smoothly and reveals even the slightest possibility of producing results, he can continue to apply.
Of course, Li Zheng thanked him a lot and used all possible methods to prepare for the experiment.
The scientific marginal team then entered the preparation stage.
It feels like a group of people who want to drive a car but can't afford it, only have a chance to test the car to prove to Ferrari that they can do it.
Therefore, before the test drive, they desperately adopted all methods to simulate driving.
Just like memorizing every turn of the track, hard memorizing every experimental link.
Just like learning from the experience of a good driver, I gnaw every experimental paper and extremely limited videos at home and abroad.
In the end, even Lin Moming shouted out
"No one knows cryo-EM better than me!"
The main reason why I really shouted out was to vent.
In the past few days, she was in the underground discussion room, pressed by Li Zheng to translate the document, and she had already translated it!
The main reason is that Mo Nian's English is too poor, because his English is still at the junior high school level due to the transfer.
And in this frontier field, as the main experimenter, it is impossible to do the job without gnawing English materials.
why?
Because even the top domestic papers are only available in English.
In this endless translation work, even Lin Moming completely understood this stuff.
This can be regarded as a disguised science study. Kobayashi's academic growth can be seen with naked eyes.
As for the leader, he has also been developed more magical functions.
That is the assembly simulation test bench.
Based on these legends of cryo-electron microscopes, he searched for materials and built a set of similar simulation equipment in the basement. He even got liquid nitrogen.
After hard work, I finally waited until September 8th.
As the sky gradually dimmed, members of the margin of science woke up one by one.
No way, only 4 hours at night.
Only by getting enough sleep during the day can you give full play to this limited time.
At 18:40, at the gate of Huayuan.
A lonely fat house has been waiting for a long time.
Shi Yang was waiting here and wanted to pretend to be forced.
But when he saw Lin Moming, his whole body was not well.
"Whose is this? No matter what, you can't bring children here!"
Lin Moming glared over hostilely, and said the mantra she used to vent during this time: "No one knows cryo-electron microscope better than me!"
After some explanation, Shi Yang quickly returned to his original state.
He just didn't dare to speak, his face was completely red like Wangwang, and he kept peeking.
When I was nervous, I went to the toilet.
Fortunately, I rushed back to the door of the cryo-electron microscope laboratory at 18:58.
Here, a group of six people are ready to go.
Although the heart beats wildly, it is still within a controllable range.
Even if they have never seen the real thing, no one knows cryo-EM better than them.
This uncomplicated little experiment has been quietly honed for hundreds of hours.
Especially Mo Nian.
He was experimenting in his dreams, and dreaming when he was awake.
The practice of the power of meditation found such a breakthrough for the first time.
Looking at everyone like this, Li Zheng finally stared.
"Stop chirping, fuck!"