Chapter 737: The grind bad guy (one/three)

Hard,
It's almost impossible.
After seeing this information, the three young postdoctoral fellows instantly retreated. After all, Xu Mang’s proposal to solve the problem of replacing a certain DNA fragment with a target sequence is a false proposition in the world. It does exist, but it cannot Be realized.
"Is it difficult?" When Xu Mang saw the three expressions, he knew that they might think they were crazy and made such requests, but these requests were precisely those made by others, and he said helplessly: The request from the court, so... let's try our best."
Suddenly,
The three of them had no words, and silently accepted the unfinished difficulty in front of them. If Xu Mang was not standing in front of them, they might have left, but Xu Mang standing in front of them, they thought there might be a chance.
"Professor Xu?"
"What kind of approach do we take?" a postdoctoral fellow asked: "Are you using the same AI model as before? Using artificial intelligence to give new life to gene editing research?"
Xu Mang shook his head and said indifferently: "I don't know... Maybe, but we must first complete the theoretical framework for replacing a certain DNA fragment with the target sequence, and this problem is not the only problem we need to solve. There will be new problems at any time."
What's new?
This...
Replacing with the target sequence problem is already outrageously difficult, and I was told that this is just one of many problems.
Finally started working,
However, it never occurred to me that the so-called starting work is to continue to do experiments from the CRISPR-Cas9 system, and only record the process of each failure. Xu Mang is responsible for checking the process of these errors.
no way,
This is the best way that Xu Mang can think of. Through the comparison of the error process, he can find the entry point. One day or two days is still stable, but as time slowly goes by, everyone’s enthusiasm is gradually worn out. It's like a walking dead.
this day,
Less than five days before school is off,
The postdoctoral fellow Xiao Chen came to the laboratory. He was going to ask Xu Mang for leave in advance. It was about to celebrate the Spring Festival. He had to go home early to avoid the peak of Spring Festival travel. However, when he told his two colleagues about his ideas , I realized that... the three of them had the same idea.
"???"
"???"
"???"
Xiao Chen said with a dazed expression: "The three of us...are all going back? This...what about this project? Let Professor Xu Mang stay in the laboratory alone? Although he is half of the magic city, But is it too cruel to him?"
"What should I do?" Xiao Shen smiled bitterly: "I can't help but go home?"
"Yes."
"After all, it's the Spring Festival, I should go back. I haven't gone back in a year." said Xiaoqian, a postdoctoral fellow. "In fact, this problem...will not be solved for a while. We have been working on it for a week, so we should just stay where we are. It is better to relax. Change your mood."
At this time,
Xu Mang came to the laboratory slowly carrying a bag of fried buns and two bags of soy milk. He saw the three people sitting and chatting together and asked with a smile, "Have you had breakfast? I bought a lot of fried buns. Shall we eat some together?"
Seeing Xu Mang's arrival,
The three of them didn't know how to speak for a while, and finally Xiao Chen said, "Professor Xu...I plan to ask you for leave today. I want to go home early to avoid the Spring Festival travel army. I haven't returned for a year..."
"Professor Xu, I also want to ask for leave."
"me too."
Faced with the three people's request for leave, Xu Mang was not surprised, he smiled and nodded: "All approved, of course I have to go back during the New Year, right..."
Words fall,
Xu Mang took out three red envelopes from his shoulder bag and handed them to the hands of the three of them. He said seriously: "I planned to give it to you later. Since you are going home today, let me give you the red envelopes now. ."
Suddenly they got Xu Mang's red envelope. The three of them were surprised for a while, but even more astonished, the red envelope was exaggerated in its thickness, and it was 10,000 yuan.
"This..."
"Professor Xu?"
"This red envelope is a bit exaggerated!" Xiao Chen said with a serious face: "We can't accept it."
"Come on."
"I don't know how much money is in it, it's all prepared by my wife for me." Xu Mang said indifferently: "Take it, it's okay... Who dares to talk nonsense, let him come to me directly, and I face it."
Looking at the parting three people,
Xu Mang once again returned to the empty laboratory. Perhaps this is his own destiny, the fate of fighting alone, sitting in the office, smoking a cigarette silently, thinking about the future, thinking about how to face failure or success.
I have been studying the problem of replacing a certain DNA fragment with the target sequence for more than a week. I was wandering around in a maze, and I couldn't find any way out. The process of seeking the truth has been so rough and the result is more cruel in reality.
After thinking about it,
Xu Mang decided to take a walk outside, and staying in the office for a long time would make his nerves collapse.
in the school,
Xu Mang walked all the way to the school gate and saw that many students were ready to go home, but the scenes before him made Xu Mang a little melancholy. He came to a coffee shop that was not closed yet, ordered himself a cup of coffee, and sat by the window. Position, looking at all kinds of people on the side of the road.
perhaps,
On the day of birth, no one knew it, but in fact this was an unreasonable world.
Some people’s dream is the sea of ​​stars, some people’s dream is a house, some people are born with talent, some people rely on sweat to support it... can't lose at the starting line, but some people have always stood at the end .
This is the reality, this is the reality where there is a huge gap, and finally accept the setting of just ordinary people.
Resigned?
however...
What Xu Mang saw was hard work. Living in this unreasonable world requires a lot of courage.
"Hey?"
"Wife?"
"I'm in... the coffee shop." Xu Mang received a call from Xiaoman and said with a smile: "No...everyone has gone home for the New Year, and I am left alone in the laboratory, so I can What to do? I can only sit outside and drink coffee."
"..."
"Speaking of going home." Yang Xiaoman suddenly fell into contemplation, and said seriously: "Husband...this year is New Year's Eve or New Year's Eve to return to your home, and then return to the magic capital on the third day of the Lunar New Year?"
"Ok!"
At this time,
Yang Xiaoman asked squeakyly: "What kind of gift do you buy?"
"No need."
"My parents can see you here, no gifts are needed." Xu Mang said calmly, "Or... buy some jewelry and get my dad some tea."
"Ok!"
"I'll do it right away."
Snapped,
Hang up directly,
Xu Mang just finished a cup of coffee and went back to the laboratory in silence. He started a day of cluelessness. It wasn't until noon that Xu Mang woke up from this hazy state, had a not-so-delicious lunch, and continued. The soul of the afternoon does not stay away.
Boil and boil,
This day was just passed by Xu Mang. He was really helpless. He wanted to rely on the system to solve it, but found that this time the system gave restrictions and can only be solved by himself. What's more, he was not careful. Triggered the task, and asked to be resolved before the New Year.
...
"Lying trough?"
"Why... why is there no one?"
Fuda in the early morning,
Xu Mang was walking on the way to the laboratory and found that the school was empty.
Sitting on a chair in the office, I took out the experimental data of the previous three postdoctors. This is the N+1th time for repeated comparison. Xu Mang has not made any progress before, and this time it is almost the same, but it has become It's just a habit.
"perhaps..."
"My thinking is wrong." Xu Mang frowned, took out his notebook from his bag, and after connecting to the Internet, he opened the database of the Institute of Biochemistry and Cell Biology of the Academy of Sciences. Xu Mang planned to replace the DNA fragment with Centralized collection of target sequence questions.
"Ugh?"
"Wait!"
"Why do I keep staring at the problem of replacing the DNA fragment with the target sequence?" Xu Mang suddenly woke up. He found that he was too iron on the problem of replacing the DNA fragment with the target sequence. This problem can be circumvented. past.
An immature idea came up. First cut a DNA strand and insert the target sequence Y, then the original sequence was cut off, and another unedited DNA strand was cut, and finally the CRISPR system repaired the cut DNA strand~www .EbookFREE.me~This is Xu Mang’s preliminary idea. Like the CRISPR-Cas9 system, Cas9 is used to identify specific DNA sequences, but Cas9 has been modified to cut only one DNA strand, and then reverse transcriptase is guided by the RNA strand Perform gene editing at the cut.
"Yes!"
"Gradually feel it!" Xu Mang was reborn suddenly, but this feeling of rebirth only lasted for ten seconds, and it was instantly misfired. If we follow this line of thinking, it seems that a lot of research and experimentation will be needed, but I don't know how to do biological research.
Looking for Xiaoman?
Xiaoman studies economics and knows how to do biological experiments.
"How to do?"
"How about... find Academician Zhong?" Xu Mang took out his cell phone, dialed the number and called.
beep,
Called,
Xu Mang hung up directly.
Shouldn't this be the time for the debut of "Xuman System 2"?
...
night,
Always come quietly,
Yang Xiaoman had just thrown all his clothes in the washing machine, and was about to go back to the living room to watch TV, only to find that Xu Mang, who was supposed to be paralyzed on the sofa, was gone.
"what's the situation?"
"Where is this guy?" Yang Xiaoman frowned, thinking that he seemed to be struggling with scientific research progress recently. Could it be...have found a solution to the problem?
He tiptoed to the door of Xu Mang’s study and gently opened a crack in the door. Through the tiny gap, Yang Xiaoman found Xu Mang sitting in front of the computer, knocking on the keyboard solemnly. After a while, he lowered his head and picked up the pen. I don't know what is being calculated on paper.
Xiao Man closed the door silently, with a trace of love in desperation.
The big bad guy!
......