Vol 3 Chapter 1893:

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In the history of the Auraless universe, the discovery process of prion has been extremely tortuous.
In fact, the initially studied prion as a pathogen that can infect human diseases [human prion disease] was discovered as early as 1955. At the time, an American explorer and doctor named Gaidasek discovered the disease when he visited a primitive tribe with cannibalism in the Papua-New Guinea Highlands.
The American doctor has even concluded that this disease, called "Kuru disease", was caused by the cannibalistic tribe devouring the brains of dead loved ones.
He used chimpanzees as experimental animals, diluted the homogenized brain tissue obtained after death of patients with Kuru disease, and injected them into chimpanzees.
Later, he used physical means to isolate larger pathogens and parasites, and to kill nucleic acids by ultraviolet light to determine the pathogen of Kuru disease.
He even tried using proteolytic enzymes to treat these homogenates.
Of course, there is no doubt that proteolytic enzymes have completely lost the pathogenic ability of these homogenates.
However, his first reaction was ... well, it must be that the proteolytic enzyme destroyed the outer shell of the "Kuru virus".
This should be a new type of virus.
At the time, this kind of thinking was very natural-it would be better to say that almost all scholars would think so.
But when Gedasiek discovered Kuru's disease and made an inaccuracy ... no, it can even be said that there was a "wrong" conclusion, Pruxina, the prion discoverer, had just entered middle school.
This achievement led Geda Sek to win the Nobel Prize in Physiology and Medicine in 1976.
In his childhood, Prusiner was wondering whether to replace hamsters with two hundred days of incubation with hamsters with only 100 days of incubation.
In addition, by the way, the earliest human prion disease that can be infected by humans was discovered in 1913 by two German physicians, Hans Cruzfield and Alvons Jacob.
Prusiner also chose to study pruritus of sheep similar to the symptoms of Creutzfeldt-Jakob disease and mad cow disease after witnessing a patient suffering from Creutzfeldt-Jakob disease in 1972.
Between 1913 and 1997, Earth scholars still had many opportunities to conclude that "prion is a special pathogen".
However, until 1996, the British caused the outbreak of mad cow disease due to the large-scale use of dead beef bone meal, and Prusiner's views were not recognized by others.
In fact, after 1997, the attitude of the entire academic community to Prusiner was only "barely accepted".
Even in 2001, when a major result of prion research was published in a journal, it was stated that "This result will strongly support Prusiner's hypothesis-Prusiner obtained it in 1997 because of this hypothesis. Nobel Prize ".
On June 14, 2001, a message was published in Nature. The Serono company announced that its research team with Dr. Claudio Soto as its core research group has developed a detection technology for abnormal prion protein.
To be precise, it reproduces the prion replication process.
Protein misfolding cycle amplification technology, referred to as PMCA.
Song Shufu will never know how difficult it is for him to be so poor.
Song Shufu's ten-year study of a number of people is equivalent to the accumulation of Prusina for eight years on the earth. With Song Shufu's foundation, Ai Qinglan could complete this research in a short time.
And now, Song Shufu's last luck has given Ai Qinglan a powerful leap.
If there is no such unexpected discovery, then at least in the next few decades, Ai Qinglan needs to continue to run around for this "hypothesis".
Of course, "saving decades of effort" does not mean that decades of problems have been solved in an instant.
In fact, this does not mean "end". There are still many problems before Ai Qinglan.
Of course, compared with his counterparts on the earth, Ai Qinglan is undoubtedly lucky.
Regarding the mechanism of prion, it is now the most optimistic in the earth academia, and the version proposed by Prusiner in 1995. Claudio Soto was based on Prusiner's conjecture, and followed the idea of ​​PCR to complete the PMCA technology.
And Ai Qinglan directly discovered such a strange phenomenon-she can directly infer the "principle" from the phenomenon.
"Why is this happening?" Ai Qinglan said in a low voice.
"Water flowing down" is because of "gravity", and "gravity" exists because of "universal gravity", and the source of gravity is "space-time bending caused by mass." The source of "quality" is the next step.
No "phenomenon" is taken for granted. Even if it does seem so taken for granted.
Under the "righteousness", this is where the "Tao" lies.
Ai Qinglan is to think about, why can the pathogenic spirit source be amplified after ultrasonic treatment?
Why is it done in a water bath with reverse transcription polymerase chain reaction?
After ultrasonic treatment, what kind of changes have happened to the pathogenic source?
What kind of process does the conventional psychic source material have to be transformed into the pathogenic psychic source material?
Why does this process not require enzyme catalysis?
What is the mechanism of action of pathogenic psychic source ...
And-is it a "life" in the conventional sense?
All of this is a problem.
"It's time to reset the proof." Ai Qinglan said so, quickly writing on his notebook.
Demonstration on re-operation at different temperatures.
Demonstration on repeating that operation under different intensity ultrasonic treatment.
Demonstration on repeating that operation under ultrasonic treatment of different duration.
Empirical repetition of that operation with different numbers of pathogenic psychic source templates.
Demonstration of repeating that operation after changing the composition of the buffer.
on……
There are too many things that can be thought of in a flash, and countless inspirations are stirred in Ai Qinglan's brain at the same time.
It can be seen that for a long period of time, this empirical department ... no, not necessarily this empirical department. Ai Qinglan's energy is enough to affect many empirical departments. And if Helix Shuangzun can recognize him, then there is an empirical department in Jiyingu that will do relevant verification. In short, for a long period of time, the relevant empirical evidence will not stop.
It's just that the development of the Misfolded Amplification Technology of the Biomass Source also means that the results that used to take several months to get can now be obtained in only a few hours.
This is simply a magical method of first class!
At the time of Ai Qinglan's exciting design proof, Chen Feng came up and said to her: "Sister Lan, I know you are very happy, but now we have other procedures to run ..."
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The outside door notification system is a special system newly introduced by Shenzhou.
The core content of this system is only one point-when a monk has made a subversive achievement, he has the responsibility to inform other Xianmeng leaders of other schools first.
A few years ago, the mass destruction of Wanfamen caused by "incompleteness" was still vivid. Many skills of Xianmeng were close to suspension for a while. Many high-level monks were unstable, and even their lives could not be guaranteed.
This is also the result of many monk monks including Feng Luoyi, a Chinese national, and Turing, a real old man, preparing ahead of time.
In recent years, a new generation of monks has gradually emerged, subverting the past much faster than in the past. One of the most typical is Wang Qi, but other monks such as Mi Tianzhao also have such signs.
There is even the suspicion that the old man is frightened, these younger generations of monks will play the dead race directly before the powerful foreign enemy attacks.
Therefore, after the massacre of the Ten Thousand Famen, Xianmeng also set up an outside door notification system in addition to the peer review system.
If you have made a subversive achievement, you should first notify the top of other schools.
In this regard, Feng Luoyi was somewhat unhappy.
Because in most cases, this "predecessor in other fields" is mostly him.
However, the direct reason for this system is his own apprentice, so he would consider whether it is appropriate for this responsibility.
Now, his brain hurts even more.
Because, the report he received this time was "this discovery is equivalent to shaking the position of Tianyan theory in the way of life".
What is the status of Tianyan theory? For some of the current Fa-cultivation, it has almost risen to the point of faith.
Although the theory of heaven evolution has been revised many times since the doctrines of genetics and blood veins were put forward, these modifications are only precise and precise, not "shaken".
If it is someone else who wrote this, it ’s okay, because since the advent of the "outside door notification system", Xianmeng has received three or five reports of overthrowing the path of conformity from the children of the fairy yard and even those from the door.
However, the report added the name "Ai Qinglan" is different.
As a metaphor, if other people run and say that they want to overturn the logic of arithmetic, then Feng Luoyi will only laugh away, but Wang Qi said this, Feng Luoyi will cut the traitor with a sword.
He had to pay attention-otherwise, Tianlingling will be directly affected by the catastrophe.
It's just that when he really listened to Chen Feng's narrative, he actually had a ... well, how to say, that kind of "but so" feeling.
In this way, can it be regarded as "equal shaking theory"?
Although every empirical department has the elements that Hu Qiping wants to spend money on, but are you a little bit over here? Is it so exaggerated?
Why can't I copy myself at such a small age?
Chen Feng was anxious. He really did not understand how to describe the significance of this discovery.
Ai Qinglan on the side opened his eyes: "Senior Feng, follow me, please let me explain."
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