Chapter 537: One more terminal illness that plagues humans

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High-precision laser processing technology has achieved success.
Regardless of the major strategic significance, the bottleneck of the reducer no longer exists in robotics alone.
Next, Lu Li planned to overcome another difficulty-the servo motor.
However... things are unpredictable.
Just as Lu Li was about to devote himself to the research of servo motors, he unexpectedly learned a piece of news that forced Lu Li to change his research direction.
That evening, Lu Li returned to Fudan's dormitory and finished dinner with Liu Qin.
"Lu Li, do you remember Wang Yan?"
Liu Qin picked up a chopstick dish for Lu Li and raised his eyes to look at Lu Li.
"Wang Yan?"
Lu Li thought about it for a moment. With a strong memory, he immediately let Lu Li search through the depths of his memory to find out the memory of his past.
Wang Yan, Lu Li's high school classmate.
In Yucheng No. 1 Middle School, Wang Yan was still at the same table with Liu Qin.
"Wang Yan, old classmate!"
Lu Li smiled and said to Liu Qin: "At first, when you were in Yucheng No. 1 Middle School, Wang Yan was at the same table with you! Why, did you suddenly mention Wang Yan today?"
"Wang Yan..."
Liu Qin sighed, "She is ill and terminally ill! She talked to me on the phone this morning and was crying. I was also very uncomfortable listening."
"Sick? What disease?"
Lu Li put down his chopsticks and asked Liu Qin.
"AIDS!"
Liu Qin sighed and shook his head, "She found a boyfriend, and it turned out..."
"It turned out to be so."
Lu Li also sighed and said to Liu Qin, "Wang Yan is calling you, is she asking me for help?"
It's not hard to guess.
Lu Li is the world's top genetic scientist and has also made major scientific achievements in the field of medicine to overcome cancer.
If anyone could possibly overcome AIDS, maybe only Lu Li could do it.
Wang Yan found Liu Qin and wanted to ask Lu Li for help. This was also natural.
"Wang Yan definitely meant to ask you for help."
Liu Qin nodded and said to Lu Li: "Lu Li, Wang Yan...it's very poor, if you can help, you can help her! Besides, conquering AIDS is also a major scientific research achievement!"
"You have so much confidence in me?"
Lu Li laughed, "AIDS, this is one of the world's five terminal diseases. Do you think I can find a cure for AIDS in a short time?"
"I must have confidence in you!"
A smile appeared on Liu Qin's face, "You are the world's top genetic scientist. If you can't do it, no one can do it."
"Haha! I love to hear that!"
Lu Li laughed, "Okay! Let me put the items on my hand first, and then turn to study AIDS treatment plans!"
"Thank you! I thank you for Wang Yan!"
Liu Qin was full of joy and quickly took out the phone and dialed Wang Yan. After the call was connected, Liu Qin said to Wang Yan, "Wang Yan, I told Lu Li. He will find a way to help you."
"Thank you!" On the phone, Wang Yan couldn't cry.
...
The next day, Lu Li came to the laboratory of Fudan Medical College.
In the laboratory, Sister Wen Wan and other graduate students are still doing human genetic testing projects, and they are not far from getting results.
Lu Li didn't bother them either, turned around and went to another laboratory, ready to study HIV.
HIV, which is a retrovirus, mainly invades T cells in the human immune system, thereby destroying the human immune system.
This is a typical virus invasion pattern.
HIV invades T cells, and then transcribes and replicates in T cells to generate countless HIV, which spreads in a large area, kills T cells in a large area, and completely destroys the human immune system.
At present, according to the WHO report, there are nearly 40 million people living with AIDS in the world, with 2.7 million new infections every year, and 2 million people die from AIDS every year. On average, tens of thousands are infected with AIDS every day.
In our country, there are nearly one million AIDS patients, covering all provinces, municipalities and autonomous regions across the country.
AIDS is very harmful. So far, there is still no real cure.
This time, because of Wang Yan's affairs, Lu Li devoted himself to research on the treatment of AIDS.
In fact, this is not only for Wang Yan, but also a major scientific research that benefits the world.
In the laboratory.
Sitting in front of the test bench, Lu Li carefully observed the process of HIV invading T cells through an electron microscope.
On the screen, HIV invades the cell nucleus and is broken down into RNA gene transcription information.
Immediately, this HIV gene transcription information is quickly combined with the DNA molecular chain in the T cell. The gene transcription mechanism is deceived so that the DNA transcription mechanism generates HIV DNA molecules based on the transcription information.
Continuously transcribing, continuously generating HIV DNA molecules. Until the entire T cell is full of HIV.
By this time, T cells have died and all nutrients are used to generate HIV.
Next, thousands of HIV leaked from the dead T cells, spreading continuously, and madly invaded other T cells.
This is the mechanism of HIV infection.
In fact, the infection mechanism of all viruses is exactly the same as this one. They combine the genetic information of the virus with the cell's DNA, continue to replicate, continue to generate new viruses, and continue to invade other cells.
For T cells, Lu Li has already done in-depth research.
When researching cancer treatment options, the CAR-T anti-cancer technology developed by Lu Li used the immune function of T cells to kill cancer cells.
Today, with regard to AIDS, the weapon Lu Li used at the beginning has become the target of a virus attack.
To treat AIDS, Lu Li still started from genetics.
In today's world, all AIDS treatment programs are unsuccessful, at least there is no cure.
From the genetics point of view, Lu Li has already thought of a solution to HIV, and it is a method that already exists in nature.
In nature, a war that has lasted for hundreds of millions of years is erupting all the time, erupting right beside us.
This is the war between bacteria and viruses.
Virus invading bacteria is no different from invading human cells. It also transcribes information from virus genes and combines them with bacterial DNA molecules, different transcriptions, and endless replication.
In the hundreds of millions of years of war between viruses and bacteria, bacteria have evolved a defense mechanism to fight viruses.
This gene sequence called "CRISPR" is a repetitive sequence in the genome of prokaryotes, and is an immune weapon produced by the struggle between bacteria and viruses in the history of life evolution.
Simply put, bacteria have evolved the CRISPR-Cas9 system in order to eliminate the virus's foreign invasion genes. Using this system, bacteria can quietly remove viral genes from their genome, which is the unique immune system of bacteria.
In fact, the gene editing technology in the world today is based on this CRISPR-Cas9 system, the gene cutting technology developed.
Today, Lu Li's idea is to use the CRISPR-Cas9 system to arm T cells.
Once HIV invades T cells, it will be cut off by the CRISPR-Cas9 system to prevent HIV infection.
If this technology is successfully studied, a vaccine against AIDS infection can be produced.
Of course, for patients already infected with HIV, this technology still has sufficient therapeutic effects.
The T cells in the human immune system can continuously replicate and proliferate. If the newly born T cells all have the ability to fight HIV, then...even if HIV kills all the original T cells, it cannot invade the newly born T cells.
In this way, HIV cannot destroy the human immune system. The surviving HIV virus will continue to invade new T cells because of the virus's continuous cutting of genetic information by the CRISPR-Cas9 system, and eventually all die.
In theory, this idea is achievable.
Now it's up to see whether the experiment can be successfully completed, and whether the CRISPR-Cas9 system can be equipped into T cells.
"Open the virtual laboratory!"
With a move, Lu Li directly opened the virtual laboratory and prepared to do research in the virtual laboratory.
"A virtual AIDS patient."
Lu Li is going to directly do human genetic experiments. This kind of experiment is not easy to do in reality, but it is very convenient to do it in a virtual laboratory.
After virtual out an AIDS patient, Lu Li picked up the syringe and took out a specimen of hematopoietic stem cells from the patient's spinal cord.
T cells in the human immune system are transformed from hematopoietic stem cells induced by thymus hormone.
What Lu Li is doing now is to equip the CRISPR-Cas9 system when hematopoietic stem cells transform into T cells, so that the newly generated T cells have cell-level immune functions.
It is not difficult to equip cells with the CRISPR-Cas9 system.
When doing gene editing, it is necessary to inject CRISPR-Cas9 shearing protein into the cells to be sheared and edited.
The real difficulty lies in how to make the hematopoietic stem cells produced in the spinal cord, in the process of transforming into T cells, automatically generate immune T cells according to the new template.
This again involves RNA gene transcription information.
Lu Li must also express the armed T cell genes in the form of RNA gene transcription information, so that hematopoietic stem cells can replicate according to this new template.
Fortunately, with Lu Li's current genetics knowledge, it is not difficult to achieve this.
Next, Lu Li extracts the genetic information target of AIDS, adds it to the gene target of the CRISPR-Cas9 shearing protein, and then injects it into T cells, combines with T cell DNA molecules, and then injects transcriptase to generate new ones. Gene transcription information.
The newly generated gene transcription information is extracted, injected into hematopoietic stem cells, and combined with the DNA molecular chain of hematopoietic stem cells.
Thus...in hematopoietic stem cells, new DNA molecular chains are generated according to the new gene transcription information, and new immune T cells are generated.
At this point, 90% of the experimental process has been completed, and then we will see the real therapeutic effect.
Lu Li cultivated hundreds of millions of prepared hematopoietic stem cells, re-injected them into patients, and transformed them into new armed T cells via the thymus.
After waiting for several hours, Lu Li took lymph fluid from the patient for testing.
It turns out that... newly generated T cells with the CRISPR-Cas9 system have appeared in large numbers.
In these T cells equipped with the CRISPR-Cas9 system, the genetic information of the virus invaded by HIV is all targeted by the target information of the CRISPR-Cas9 system, directly shortening the genetic information of HIV, and smoothly killing an HIV.
The immune system is still constantly generating new T cells. These new T cells are all new T cells equipped with the CRISPR-Cas9 system, and they can all kill the invading HIV.
After a round of replacement of the T cells in the patient's body, once HIV invades the new T cells, they will be destroyed one by one and eventually disappear completely.
This process... lasts about one to three months, and within half a year at the longest, HIV will be completely killed.
Of course, before a complete cure, the HIV in these patients is still highly infectious.
It took two weeks in reality, and more than four months passed in the virtual laboratory. This virtual AIDS patient was completely cured.
Lu Li conducted a detailed test on this virtual patient, and there was no HIV in the patient.
The experiment was successful!
Next, Lu Li repeated the genetic experiment in reality. Human experiments cannot yet be done in reality.
After repeating the genetic experiment in reality, the following time is the time to write a paper ~ EbookFREE.me~ a CRISPR-Cas9 technology-based AIDS treatment plan. "
In this paper, Lu Li wrote all the theoretical expressions of CRISPR-Cas9 technology, theoretically demonstrating the feasibility of using CRISPR-Cas9 technology to edit and modify T cells for the treatment of AIDS.
Of course, in this paper for public publication, there are naturally no detailed experimental data and no detailed operation steps. It is just a theoretical demonstration.
Another piece of technical information with detailed data and experimental procedures was sent directly by Lu Li to the Institute of Medicine, Chinese Academy of Sciences.
The published papers were submitted to the international authoritative medical journal "The Lancet", and the papers were also posted on the academic network.
So...Professor Lu was once again famous all over the world.
"Oumaika! Professor Lu has developed a treatment plan for AIDS!"
"Professor Lu finally remembered that he is a medical scientist?"
"The great medical scientist who conquered cancer also conquered AIDS."
"This is a great achievement! Tens of millions of AIDS patients around the world ushered in their salvation."
"Is AIDS not bothering humans anymore? This is really good news."
"Professor Lu is the Nobel Prize in Medicine. No one except him is eligible to receive the Nobel Prize in Medicine."
"There is one more terminal illness that afflicts mankind. Even the most demanding people must admit that Professor Lu is the greatest scientist in the world."
The scientific and medical circles expressed their warm appreciation for Lu Li's achievements in conquering AIDS.
Even...the foreign media are all advocating it.
Professor Lu has such a high talent in medicine, of course, he must focus on medical research to benefit all mankind. Don't be distracted by other science and technology.