Chapter 156: Mutation breeding

Hearing Zhou Wen's words, Zhu Linqing secretly said "bad".
　　 Listening to what the other party means, it is clear that some CRO companies have offered more favorable terms.
　　 After hanging up the phone, Zhu Linqing frowned as he looked at the new version of Sildenafil's patented technical instructions on the computer.
　　 Although the conditions offered by Yaoming Kant are harsh, they are considered a "conscience price" in the industry. Generally, CRO companies really dare not say that they can be more superior than the conditions given by Yaoming Kant.
　　 Since this CRO company dared to rush for food, it must have seen the huge market potential of this drug.
　　Even, sildenafil granules have been made in advance according to the technological process, and preliminary clinical trials have been done, and the efficacy is very significant, so I can’t wait to cooperate with Zhou Wen.
　　 After some analysis, Zhu Linqing believes that his guess should not be far from the truth.
　　 Thinking of this, he immediately picked up the phone and called the laboratory.
　　 "Hey, Director Shao, I have sent a document to your mailbox. You follow the above technical process and send it to me as soon as possible. I will get the efficacy evaluation report within 48 hours."
　　 Two days later...
　　 Zhu Linqing got the drug efficacy test report.
　　 Skim through the previous toxicology test data reports and look at the results directly.
　　 Number of people participating in internal testing: 6.
　　 2 people had mild ED, 2 had moderate ED, and 2 had severe ED.
　　According to the test, the new version of Sildenafil Granules has a particularly significant effect on the treatment of ED symptoms. The 6 test participants all have very bright data...
　　 Zhu Linqing looked at the test report and regretted his intestines.
　　 Such a drug effect, if the side effects are not too obvious after returning to clinical trials, it is almost a 100% thing to replace the old sildenafil tablets after returning to the market.
　　 "No, I can't just give up like this..."
　　 Zhu Linqing immediately decided to have a detailed interview with Zhou Wen.
　　 No matter how bad it is, I still have to find the company that cut Hu and get a share of the pie.
　　……
　　 On the other side, Xu Yuting came to Jiangzhou on the afternoon of the 30th.
　　 At three o'clock in the afternoon on December 31, I saw Zhou Wen in the office of Hengfeng Building in Jinhu District.
　　Exception Chen Zhiyuan and the lawyers of both parties were also present.
　　 "Hello Mr. Xu~"
　　 "Hehe, hello~"
　　 The two shook hands and looked at each other at close range.
　　 In Zhou Wen's eyes, Xu Shuangyu's little aunt has excellent appearance and elegant temperament, and is different from the so-called strong women. Xu Yuting is full of the personal charm of female entrepreneurs, which makes people very good.
　　 In Xu Yuting's view, Zhou Wen looked much more real than the brilliant young genius on the podium.
　　 "This is Chen Zhiyuan, the general manager of Huanyu."
　　 "Hello, President Chen."
　　 "Hello Mr. Xu, please sit down."
"OK, all right……"
　　 Xu Yuting is a standard businessman, and Zhou Wen is also considering how to maximize patent benefits.
　　 So there is not too much politeness, after a few simple greetings, I get to the subject directly.
　　 In fact, Xu Shuangyu had already roughly talked about Long Kang's conditions before.
　　 Zhou Wen authorized the new sildenafil pellets to Longkang, and Longkang was responsible for the promotion and operation.
　　 The money earned is divided into nineteen.
　　 Long Kang 90%, Zhou Wen Yicheng.
　　 Don't get excited.
　　 Zhou Wen this 10% is 10% of total sales.
　　 Remember, it is "sales."
　　 In other words, if the new version of sildenafil pellets reaches 1 billion in annual sales after it goes on the market, Zhou Wen will be allocated 100 million.
　　 10 billion is one billion.
　　 Although Longkang Group took 90%, they are all responsible for clinical trials, new drug listing applications, and promotion and sales of this 90%.
　　Secondly, the profits of downstream distributors are divided into these, and the 90% is also deducted from that, so in fact, the profits Longkang obtains will be greatly diluted.
　　 In addition, the two parties have a guarantee agreement.
　　 Since the signing of the agreement, regardless of whether Sildenafil Granules can be listed or not, and how the sales after the listing are, Zhou Wen must pay a patent fee of 20 million yuan (included in sales) every year.
　　 Because of this, after eliminating all costs, Longkang basically made no money in the first three years. And failing to make money means losing money.
　　 So Longkang bet on the post market.
　　 won the club young model, and lost to work in the sea.
　　 Xu Yuting and Zhou Wen discussed some details of the contract, but the overall direction remained unchanged.
　　 After half an hour of research and discussion, Chen Zhiyuan, on behalf of Zhou Wen, formally signed an authorization contract with Long Kang.
　　 Zhou Wen’s authorization is not his own person, but Huanyu Biotechnology Co., Ltd.
　　Because he is a technology shareholder, he has already handed over the patent rights to Huanyu Biotechnology Co., Ltd. to be the sole agent, and then Huanyu has authorized it to Longkang Group.
　　 When the shares are negotiated again, the patent right will be changed to the main body of the company.
　　 This can not only enhance the company’s intangible assets and corporate image, but also involves applying for government projects, patent funding, and reasonable tax avoidance...
　　 There are many benefits in short.
　　 "Mr. Xu, happy cooperation."
　　 "Happy cooperation~ After New Year's Day, the 20 million guaranteed patent fee will be credited to the account of Universe."
"OK, all right……"
　　 Then Zhou Wen sent Xu Yuting downstairs.
　　 At the entrance of the company building, Xu Yuting suddenly smiled and said, "By the way, Pisces will return to China next week."
While 　　 was talking, Xu Yuting watched Zhou Wen's expression.
　　 Zhou Wen smiled and said: "Well, she told me, wait to come back and invite her to dinner."
　　 Xu Yuting didn't see anything on Zhou Wen's face, and said with a bright smile: "Then I will go first."
　　 "Okay, Mr. Xu, go slowly..."
　　 The Spint that Zhou Wen watched Xu Yuting ride slowly started, and then disappeared from sight.
　　 He turned upstairs, took some things, and was about to leave.
　　Chen Zhiyuan came over and said with a smile: "Ai Lao Zhou, the last time Xiao Min kept asking me why your phone could not get through, did you block her?"
　　 Zhou Wen said: "No, I just reported a number casually."
　　Chen Zhiyuan grinned and said: "Nice~ You have already grasped the essence of not being active, not rejecting, and irresponsible."
　　 "Fuck it~ It's because of you guy, I'm so depraved now."
　　 "Don't say that. The love of beauty, everyone has it, at most it is a little fraternity, how can it be called depravity?"
　　 "Fine, you go to Boai. I went to the laboratory~"
　　 Zhou Wen got the car key and was about to leave.
　　 Chen Zhiyuan said: "Lend your car to me, I will wait to see a client~ My car is too much."
　　 "Then give me your car." Zhou Wen threw the key to Chen Zhiyuan.
　　 Chen Zhiyuan spread both hands and said, "I have loaned my car to someone in the company to do business."
　　 Zhou Wen said silently: "Then TM what am I driving?"
　　 Chen Zhiyuan chuckled and said: "You drive a Ferrari. Tens of millions of cars, you can't throw them in the garage every day."
　　 Zhou Wen: "Well, how can I drive to the laboratory?"
　　 "How about... I and Xiao Liu at the front desk borrow an electric car for you to drive?"
　　 "Go~"
　　 "Ah~ okay." Chen Zhiyuan took the key and left.
　　 "Just show off the bag." Zhou Wen didn't bother to call Didi, so he took the key of Ferrari F12tdf from the office and went downstairs.
　　……
　　 404 Jinhu District Industrial Park, Huanyu Institute of Biotechnology.
　　 In the open-plan office, seven or eight people, including Wang Hua, Sun Xin, Song Xuezhang, Bai Xuan, Luo Chunlei, are gathering together to study and discuss.
　　 This is the person in charge selected by many Ph.Ds. He has very good character and academic ability, and he also has certain leadership skills.
　　 Everyone agrees.
　　 And the technology they are discussing at this time is "mutagenic breeding", which is one of Huanyu's next key development projects.
　　 The so-called mutation breeding technology is actually similar to the rice aphid genetic modification technology that Zhou Wen studied before.
　　 is the use of physical, chemical and other factors to induce mutations in organisms under artificial conditions, select from them, and cultivate new species of animals, plants and microorganisms.
　　 For example, chemical mutagenesis, the more commonly used are alkylating agents, such as ethyl methanesulfonate (EMS) and diethyl sulfate (DMS).
　　The method of use is very simple, dilute it to a certain concentration, and then put the seeds that need to be mutagenized into it for a period of time.
After 　　, the mutagenized seeds are germinated, and plants with the desired traits and phenotypes are selected, and then selfed or crossed to select stable genetic mutants.
　　 Of course, the workload of screening is very huge. For tomato, sometimes tens of thousands of seeds have to be screened to find the desired traits.
　　 There is also physical mutagenesis.
　　The principle is to use various radiations to accelerate the mutation rate of plants, among which Gamma rays, α rays, β rays, γ rays, X rays, ultraviolet radiation, etc. are commonly used. These operations require special equipment.
　　 One of the more well-known is the laboratory of the Institute of Radiation Breeding in Japan. They built a tower for radiation treatment and surrounded by a test field.
　　 After some discussion, everyone selected two research targets-grapes and strawberries.
　　 These are two kinds of fruits commonly found in greenhouses in Sodong Province.
　　 Just when they were preparing to assign tasks, footsteps came from the door of the conference room, and everyone turned their heads subconsciously to see that it was Zhou Wen who was here.
　　 "The week is here."
　　 "Good week."
　　 "Hehe, everyone is here, sit down..."
　　 Zhou Wen stretched out his hand to signal everyone to sit down, and then sat down beside Wang Hua, "What are you discussing?"
While 　　 was talking, he had already seen the research plan on the table, as well as related materials about mutagenesis.
　　 Song Xuezhang, who was sitting across from Zhou Wen, said: "We just selected two goals..."
　　Following Song Xuezhang's narration~EbookFREE.me~ Zhou Wen suddenly heard four or five task prompts in succession.
　　 Zhou Wen: "……"
　　 He has never received so many tasks at once.
　　 Opened the system task and looked at it. There was a long row of new tasks on the list.
　　【Task 1: Radiation breeding.
　　Requirement: Establish a grape radiation breeding research group.
　　Reward: 2000 subject experience, 1000 points, one chance to draw (Bronze)]
　　 [Task 2: Chemical breeding.
　　Requirement: Establish a research group for chemical breeding of grapes.
　　Reward: 2000 subject experience, 1000 points, one chance to draw (Bronze)]
　　【Task 3: Radiation Breeding 2.
　　Requirement: Establish a strawberry radiation breeding institute...]
　　 The requirements of Task 3 and Task 4 are similar, except that the requirements have changed from grapes to strawberries.
　　 The first few tasks, in his opinion, the system sent points.
　　 But the latter is more exaggerated.
　　 For example, task 5 requires cultivating an average of 50 grams of grapes.
　　Fujiminori, China's largest grape variety, has an average single grain of only about 22-30 grams, and the largest one is only 35 grams.
　　Task 6, it is required to cultivate strawberries with a single grain of up to 500 grams.
　　 This is even more exaggerated, the world record is only 231g, this has more than doubled, the system really looks up to him...
　　
　　Ps: Sorry, please...