Chapter 292: Analgesics that do not produce euphoria

　　 "It is said that Huanyu has completed the development of active compounds and is currently undergoing pharmacological evaluation."
　　 Tianfeng Zhengda executive director Lang Yongfeng said, looking at the paper data on the table.
　　As a pharmaceutical company that started from generic drugs, Tianfeng Zhengda has also invested a lot of money in new drug research in the past two years.
　　 However, the development of new drugs does not produce results in a short period of time, nor does it mean that there will be results.
　　 Even in the stage of clinical trials, as drug evaluation becomes more difficult, fewer new drugs can be marketed through all phase 3 clinical evaluations.
　　 Part of the reason is that it is becoming more and more difficult to develop new drugs with better comprehensive evaluation than existing drugs on the market. For example, last year the FDA (US Food and Drug Administration) only approved 35 new drugs.
　　 Like Tianfeng Zhengda invested heavily in the research and development of a second-class new drug, it has entered the second phase of clinical trials, and the result was aborted. All the US$75 million invested in the early stage was lost. It was very miserable.
　　 Of course, drug research and development is also an industry with high investment, high risk and high returns.
　　Once the drug is successfully marketed, the rewards are also amazing.
　　 There is a term in the industry called "blockbuster", which refers to drugs with annual sales of more than $1 billion.
　　 An extreme example is Pfizer’s patent-protected lipid-lowering drug Lipitor. In 2010, global sales reached a staggering US$10.133 billion.
Hearing Lang Yongfeng’s words, a middle-aged man with four eyes pushed the frame on the bridge of his nose and said:
This company’s R&D capabilities are very strong, and it’s almost a solid fact that it enters the clinical trial stage; I just don’t know how successful it will be. ?"
　　 Another man with a three-faced beard smoked a cigarette and said, "I think you are all unreasonably worried. This is nowhere. Even the clinical trial has not started. What is there to worry about."
　　 Lang Yongfeng shook his head and said: "You are wrong, I am not unreasonably worried. He Junfeng, the type B chief scientist of the Academy of Sciences, has joined their team. Do you know what this means?
You may not know He Junfeng. He is very arrogant. Xie always wanted to invite him to serve as our company's chief expert consultant. He even offered a ten million annual salary + bonus equity. As a result, he refused to even look at it. .
　　 He can join the world creatures, just to explain one thing, the other party must have something he can't refuse. "
　　 The four-eyed middle-aged man said: "Mr. Lang meant that... Huanyu has made a breakthrough discovery in the treatment of hepatitis B?"
　　 Lang Yongfeng nodded affirmatively: "Yes!"
　　……
　　 Ruiyang Pharmaceutical Factory, Science Park Avenue, Kapok City, Sichuan Province.
　　 Ruiyang is just a small pharmaceutical factory, which is mainly a manufacturing agent factory, with a total of more than 30 employees and four technicians.
　　These technicians, in addition to being responsible for daily production in the factory, also conduct some drug research.
　　 is mainly analgesics.
　　 And the reason why they study analgesics is mainly because of the boss and technical director Fu Le.
　　 Fu Le used to be an anesthesiologist. He left his job seven years ago because of some things, and accidentally entered the pharmaceutical industry. Then, out of work, out of personal hobbies, he began to research analgesics.
　　 But today, Ruiyang Pharmaceutical Factory is about to close down, because the contract processing business continues to shrink, the factory can no longer continue to support, and has to close.
　　At this time, the four technicians in the laboratory looked at the packaged experimental equipment on the ground with a look of dismay, but it was useless to give up. They always wanted to live and had to make another way of living.
　　 It's just a pity that the boss Fu Le, he is a man with ideals and sentiments, and he has paid practical actions for his dreams.
　　 "Let's go, go with the old man alone."
"go……"
　　 Several people looked at the experimental instruments on the ground again, sighed and left the laboratory.
　　 In the office, a man in his forties with a thin face is calculating the company’s property according to the documents given by the accountant.
　　 After some calculations, after excluding all the expenses, after selling all the equipment, not only a penny is not left, but also one hundred thousand yuan owed.
　　 This man is naturally Fu Le, the boss of Ruiyang Pharmaceutical Factory.
　　 Fu Le gave a wry smile. In May 2013, it has been 7 years to this day. In the end, he was busy with nothing and nothing.
　　 Fortunately, his wife divorced him a long time ago, and took the child away with him, otherwise he would follow him, and now there is nowhere to stand.
"pretty good!"
　　 Fu Le picked up his mobile phone and called the second-hand equipment recycler, "Hey Boss Zhang, come and pull the equipment..."
　　 After making the call, Fu Le closed the computer and planned to leave, but at this moment, the phone on the desk rang.
　　 "Hello, hello, who may I ask?"
　　 There was an infectious baritone on the phone, "Are you Mr. Fu?"
　　 Fu Le: "Yes, I am, who are you?"
Baritone: "I am Tong Miao, an evaluator of the Universe Biological Research Foundation. After receiving your application, we have evaluated your company and experimental projects. Now I have some questions to ask you. Is it convenient for you now? "
　　 "Universal Foundation?" After listening to the other party's words, Fu Le was stunned, and then suddenly remembered that he seemed to have filled out an application form last month.
　　 "By the way, Huanyu Scientific Research Sponsorship."
　　 Fu Le remembered.
　　 He applied for a 1 million research grant from the Huanyu Research Foundation in the past month.
　　 Although I knew that there was little hope, I was desperate at the time and filled out some information in the hope of in case.
　　 I didn't expect the Foundation to call myself.
　　 "Well, you ask." Without realizing it, Fu Le became more respectful.
　　 There is no way, who makes the other party the God of Wealth? Whether Rui Yang can continue to maintain it depends on whether the other party is relieved.
　　 Tongmiao: "The entire call was recorded."
　　 Fu Le: "Hmm! I see."
　　 Tongmiao: "Okay, now it's officially started. I see in the application note that you have been an anesthesiologist for 11 years, why didn't you do it in the end?"
　　 Fu Le: "Because of relationship problems."
　　 Tongmiao: "Then why do you want to study painkillers again?"
　　 Fu Le: "Because I believe that any real anesthesiologist would like to develop an analgesic that can effectively block pain without producing euphoria."
　　 Tongmiao: "I don't understand too much, can you elaborate on the reason?"
　　 Fu Le: "Okay! It sounds a little bit nonsense. Analgesics to relieve pain are part of the business. Wouldn't it be better to provide euphoria?
　　 However, countless problems in the world are caused by this feeling of "making you cool".
The word "euphoria" sounds high-sounding, but it is almost two-in-one with the words "inhalation D", "D addiction", and "withdrawal reaction".
You may not know it. The sad fact is that saving hundreds of millions of cancer and severe pain patients, and at the same time an analgesic necessary for surgery, is being abused by addicts seeking pleasure, and has become a "D product" ".
　　 You look like the most commonly used analgesic at the window is opioids. The opioid here is actually a euphemistic English translation. In fact, the exact name is Y film.
　　Opioids originally refers to resin exudates extracted from poppy capsules. Later, with the development of the chemical industry, it has been transformed into artificial semi-synthetic, fully synthetic anesthetic and analgesic drugs.
　　Morphine, buprenorphine, fentanyl, dulantine, tramadol, methadone, etc. are commonly used clinically. There are also various analgesic plasters and emulsions that also contain opioids.
　　Opioids are strong analgesics, and bind to opioid receptors after entering the nervous system, which can quickly increase the body's pain threshold, reduce the body's perception of pain, and produce a powerful analgesic effect.
　　 But its other function is to give users a special feeling of euphoria and a very pleasant and comfortable feeling, which is the root cause of the abuse of such drugs.
　　 Euphoria and addiction can hardly be stripped away~EbookFREE.me~ Supernormal pleasure is pleasure and hell.
　　 It’s not a problem to be cool, the problem is to keep being cool.
　　 The subjective willingness of human beings to seek strong stimulation is almost endless.
　　 After experiencing a pleasure that is far beyond imagination, any ordinary stimulus is like tickling. Once the pleasure threshold is raised, it is difficult to be suppressed.
　　 The so-called hard to go from extravagance to frugality, and wanting to be refreshed after being refreshed, is addiction.
　　 An addiction has ruined countless people.
As an anesthesiologist, I am very sad to see that many drugs that were originally invented to benefit mankind are abused into D products. This not only stigmatizes the drug, but also stigmatizes patients with extreme pain and legitimate analgesia needs. Serious crimes committed.
　　 For example, chloramine is an excellent short-acting analgesic in the field of pediatric anesthesia. It has fast onset, fast metabolism, and has the function of dissociative anesthesia. It is very suitable for use in pediatric short-term and rapid surgery.
　　 But it is now called K-Fen. No one knows that it used to be a good helper for anesthesiologists.
　　Because of this, I especially hope to understand the entire pain signal as soon as possible and develop an analgesic that does not rely on opioid receptors and can effectively block pain..."
　　
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