Chapter 738: Far beyond expectations (2/3)

this day,
Institute of Biochemistry and Cell Biology, Academy of Sciences.
Academician Zhong was very dissatisfied with the progress of the Molecular Biology Department, but Xu Mang didn't have any news for a long time. For a while, he felt a little desperate. He saw that the Chinese New Year was about to be celebrated, but why was his heart so bad?
"Ugh..."
"Is the project going to last a year?" Academician Zhong originally thought that finding Xu Mang could quickly solve the breakthrough problem in the field of gene editing, but the fact is just the opposite. He seems to be in a dilemma.
The time to talk to Xu Mang on the phone should have been ten days ago. The weak voice at that time, I'm afraid...I'm horrified by this question.
At this time,
Academician Chu, an expert in bioinformatics, came to Academician Zhong’s office and saw his helpless expression. He couldn’t help but smiled bitterly:
I said Lao Zhong... You’ve been frowning for almost three months. It’s almost done. New Year is coming, can you change your expression?"
"Ugh..."
"I want to change too, but how?" Academician Zhong sighed: "The progress of the Molecular Biology Department is almost zero, and Xu Mang's situation is not very optimistic. I am afraid it will be delayed indefinitely. The next year's research funding will be It will be greatly reduced, at least about 20% in the field of gene editing."
"Nothing."
"The matter is too big...some people are opposed." Lao Chu sat opposite Academician Zhong and said silently: "But you are much better than Xu Mang. The collider project has been stuck because of this project problem, Xu Mang He even quit his job as a professor. His difficulties are more serious than yours."
Hearing what Lao Chu said, Academician Zhong smiled bitterly: "Yes...not the difficulty of a concept."
"Speaking..."
"Have you contacted Xu Mang?" Lao Chu asked curiously, "Why don't you... make a phone call and ask. I have a strong hunch that Xu Mang may have made a breakthrough in the field of gene editing. Question, when did you connect with Xu Mang before?"
"Ten days ago."
"Ten days ago?" Lao Chu's face showed a bit of bitterness: "No ten days can be worse, you can ask now... it may give you an unexpected result, by the way... hands-free!"
Academician Zhong:? ? ?
what's the situation?
How old Chu is weird today.
no way,
Academician Zhong called Xu Mang, and the call was quickly connected.
"Hey?"
"Academician Zhong?" Xu Mang's voice came out, with a hint of playfulness in his words, and said: "The New Year is coming soon... I will pay you a New Year in advance, so I won't go... The distance from the capital is not so far."
"..."
"..."
The two of them were helpless and seemed to be...in a good mood. Should I ask next? After all, the Chinese New Year is coming soon. It is not very good to add a blockage to others at this time.
Academician Zhong hesitated and asked several times to ask about the progress, but he swallowed it back, thinking about it... or giving up the plan to ask.
but,
Xu Mang mentioned it.
"Academician Zhong called me, do you want to ask questions about progress?" Xu Mang smiled and said, "I'm almost done...a basic AI system has been developed and is currently being tested. I guess... it's coming soon."
"???"
"???"
Engage in...
Did it?
This is too unexpected, right?
Academician Zhong and Academician Chu looked dumbfounded and glanced at each other. There were shocked expressions on each other's faces, as well as a little inconceivable.
"In this concept of mine, I bypassed the problem of replacing the DNA fragment with the target sequence, and cut a DNA strand directly, and then the reverse enzyme was guided by the RNA strand to edit the gene at the cut site." Xu Mang said seriously. : "Although it is still the CRISPR-Cas9 system, I have modified Cas9."
Bypass?
This...this idea is fine!
Academician Zhong hurriedly said: "Can you be more specific?"
"can!"
"First cut a DNA strand and insert the target sequence Y, then the original sequence is excised, and another unedited DNA strand is cut, and finally the CRISPR system repairs the cut DNA strand."
"In this way, the enzyme does not need to cut the double strands of DNA, so researchers do not have to rely on their uncontrollable DNA repair system to perform gene editing on the cut DNA strands." Xu Mang paused and said seriously: "It means to use new editing The system can develop genetic diseases related to genetic mutations."
For a while,
The two academicians were completely silent. What Xu Mang said was based on the existing gene editing tools, which simply couldn't do this.
"correct!"
"I thought of another method the day before yesterday." Xu Mang smiled: "Its accuracy is comparable to my editing tool system. This technology can directly realize base substitution without cutting the double strand of DNA through chemical methods. For example, replace T with A and G with C."
"The CRISPR-Cas9 gene editing system can't do this, but..." Xu Mang sighed: "This method cannot solve the problem of multiple bases, such as the translated black idiot symptoms. This is It is caused by the mistaken insertion of 4 DNA bases in the HEXA gene."
This...
This is simply,
Too tough, right?
Hearing Xu Mang's introduction, the two academies of science were so shocked that they couldn't speak, sitting in their original positions blankly.
"Anyway..."
"My positioning for the new system is flexible, simple, and capable of achieving multiple gene editing functions." Xu Mang said earnestly: "A system composed of a variety of enzymes, including the improved Cas9 enzyme, can be used almost without Change or delete single bases or insert small DNA sequences in the case of damage to the double strand of DNA."
Academician Zhong took a deep breath and asked carefully: "Xu Mang...how long will it take to finish?"
"Before Chinese New Year."
"Give me another five days. When I finish the test, I will give it to you..." Xu Mang smiled: "You can perform simulation tests through AI, modify according to the test results, and then go to the laboratory for the final test. ."
"Anyway, it is to reduce your workload. After all, the future is an era of artificial intelligence." Xu Mang said helplessly: "Academician Zhong...this is the result of my best efforts. If the result is still not satisfactory. , Sorry...I really can't do anything in the back."
Not satisfied?
What a joke!
This is clearly beyond expectations!
What Xu Mang said is more advanced than any modified CRISPR-Cas9 system because it does not rely on the cell's own repair system for gene editing.
"Do not!"
"Professor Xu... if all this becomes a reality, I dare to swear... your new system will become the world's most advanced gene editing tool." Academician Zhong said seriously: "I'm not kidding, it's already super It’s beyond any imagination."
Xu Mang opened his mouth and whispered: "Academician Zhong... I have a request, can we strengthen the constraints in the field of gene editing in the future? I think... I am a little worried, worried that the future of humanity may not be in the true sense. Humans."
"I know what you are worried about."
"In this respect... our binding force is not enough, including a very serious mistake that appeared not long ago." Academician Zhong's tone is a little serious: "I will propose relevant measures recently and implement them all within one year. ."
"Oh..."
"That's fine." Xu Mang said, "I'll hang up first."
moment,
Call interrupted,
However, the excitement is still entwined in the hearts of Academician Zhong and Academician Chu. It is impossible to imagine what they have just heard. Unexpectedly, Xu Mang has really done what the world has not done in this field. He has broken through gene editing. Dilemma in the field.
"Old clock..."
"What should I do?" Academician Chu smiled bitterly: "Such a genius turned out to be a physicist... You are not angry?"
"Ugh..."
"There is still a huge gap between our researcher and the world's top class." Academician Zhong said helplessly: "It's a pity...There is only one Xu Mang in this world. I really hope that there will be more. I can't imagine what will happen in the future."
"One Xu Mang is enough... he is almost omnipotent." Academician Chu smiled: "If you have difficulties, you can find Xu Mang. There is nothing wrong with this sentence!"
...
at the same time,
Far away in a villa in the magic city,
Xu Mang is sitting on the sofa, watching a boring TV series with Xiaoman. This TV series is very thought-provoking. It reflects the education problems of modern families for their children, and also reflects the children's face Helpless when learning pressure.
"Husband?"
"You said... will our children be stupid in the future?" Yang Xiaoman frowned and asked seriously: "You are a great scientist and I am a big entrepreneur. As a result, our children... The grades are always countdown in the whole school~EbookFREE.me~ Who will go to the parent meeting from now on?"
Xu Mang: (°ー°〃)
Yes indeed!
In case it is very skinny, who will this parent meet?
"I dont go!"
"I won't go to kill me..." Xu Mang shook his head, and said with a serious face: "I am a great scientist, and I want to have a face, anyway...I won't go for anything."
Yang Xiaoman is so angry. In fact, she doesn't want to be ashamed, but two people must go to one. What can I do?
At last,
Under the surrender of force, Xu Mang became the first person to hold a parent meeting.
"in fact..."
"It doesn't have to be the countdown, but it may also be number one." Xu Mang gently put Xiao Man in his arms, leaned to her ear and said: "I ask you a question, in a certain potential field. The problem of the absorption cross section of bound electrons to plane light waves."
"Excuse me if the electron is bound by the underlying potential..."
Before Xu Mang finished speaking,
Yang Xiaoman glared fiercely, and said angrily: "Get out! I won't listen to my mother!"
"Hey..."
"No way, right?" Xu Mang said with a smile: "The problem is found, but you are too stupid, which drags down my smart and powerful gene."
Yang Xiaoman: (￣︿￣)
After a family education, Xu Mang held Xiaoman with a little grievance on his face.
But it is certain,
Xu Yang and Xu Man are already invincible in fighting.
...
this day,
Xuman System 2 was completed, but the real data from the laboratory was lacking.
"Hey?"
"Academician Zhong."
"It's done, but... I would like to ask you to lead the entire team to help me verify the correctness of the AI ​​simulation!"