Chapter 358: We are witnessing history

"Go, let's go to the Cancer Institute!"
After reading Lu Li's paper, Professor He quickly got up, "Let's go to the laboratory to verify it."
If it is an irrigation paper, there is no need for verification. This Lu Li has extremely high scientific research value, and it can even be said to be a groundbreaking great achievement. Naturally, it has to undergo comprehensive and detailed verification.
So Professor He and Lu Li hurried out of the office and rushed all the way to Fudan Cancer Institute.
"Lao Guo, Lao Guo, come!"
Entering the Cancer Institute, Professor He raised the papers in his hand, shouting all the way through his throat.
"Here! I am here!"
Professor Guo popped his head from the office door.
Seeing Professor He running over with excitement, and with Lu Li behind him, Professor Guo quickly asked: "Lao He, what are you doing so yelling?"
"Lu Li has come up with the results of the research, quickly organize the manpower and verify it."
Professor He walked like flying, shouting as he walked.
Research results?
Hearing what Professor He said, Professor Guo was taken aback for a moment, looking at Lu Li with a bit of horror.
Is this fruitful?
It’s been more than two months since the last release of the CAR-T technology improvement plan? Is it fruitful again?
The busy graduate students and doctoral students next to him also stopped one by one, looking at Lu Li one after another, thinking: What are you doing again?
"Old Guo, come and take a look!"
With a red face, Professor He walked vigorously, walked into Professor Guo's office a few steps, and stuffed the paper materials into Professor Guo's hands, "Quick, organize verification."
"Why? Let me take a look first!"
Professor Guo was still calm, ignored Professor He's yelling, and looked at the paper materials.
"The application of gene editing technology for T cells and B cells in CAR-T technology."
application?
Seeing this keyword, Professor Guo's eyes twitched a few times. Dare to write the application in the title, is it... Lu Li is sure that this technology is mature?
CAR-T technology is mature, what is the concept?
As the research leader of the Cancer Research Center, how can Professor Guo not know the CAR-T technology?
This new technology that is still in the exploratory stage, once it matures, it will be... found a specific medicine for cancer treatment, and found the most reliable technology for cancer treatment.
From a clinical point of view, this can be considered as a cure for cancer!
If this technology is true, if it is really feasible and reliable after verification, then... the scientific research results of Lu Li will be a great historical breakthrough!
We are witnessing history!
Professor Guo set off a huge wave in his heart, and the hands holding the materials were shaking slightly.
Taking a deep breath, Professor Guo helped his glasses and looked at the paper seriously.
Word by word, carefully study it carefully.
Modify T cells to include cancer cells on the "hostile list" and weaken the ability of T cells to "call friendly forces." This is the result of Lu Li's previous research.
Now, in this paper, Lu Li gave a new idea. On the basis of modifying the genes of T cells, Lu Li further modified the genes of B cells, so that the B cells shielded the "logistics and command capabilities."
In theory, Lu Li's idea is correct and feasible.
It's just that... to achieve this goal, it involves very specific gene editing techniques.
To accurately modify a certain function of a B cell, a very specific and very precise gene editing operation is required. It is very likely that... the gene operation to modify a certain function of a B cell will not be done for a long time.
"The idea is right."
After reading the paper, Professor Guo nodded, and then glanced at Professor He and Lu Li, "However, it is too early to talk about application? This is just a directional theoretical research paper and cannot be used in practice. Link."
Putting down the paper in his hand, Professor Guo glanced at Lu Li and the two of them, and said: "To accurately edit the genes of B cells, it takes a long time to research before we can find the gene targets and select the genes we want to edit. Fragment. Let’s do research on this first."
"no need!"
Professor He smiled, and took out another document, "The experiment has been done. This is an experiment report."
"Uh?"
Professor Guo widened his eyes, "Has it been done?"
He quickly grabbed the experiment report from Professor He, and Professor Guo looked at it seriously.
In this experiment report, Lu Li wrote out each step of the experiment in detail, and wrote out various detailed data such as reaction time, ambient temperature, humidity, and equipment and meter readings.
This... actually succeeded?
Lu Li has completed all the experimental steps, only one result is left for verification.
Professor Guo raised his head to look at Xiang Lu Li, the corners of his mouth trembled, "You...have completed all the techniques for B cell gene modification?"
"Yes!"
Lu Li nodded, "We are here this time just to verify the results on your side."
"In more than two months, the B-cell gene editing technology was developed. How did you find the gene fragment? How did you locate it?"
Professor Guo is still a little unbelievable.
I did no first experiment in the virtual laboratory!
In reality, for more than two months, I don’t know how many more experiments and how long it took to find the gene fragments in the virtual laboratory.
Of course, Lu Li could not say that, he could only say: "Maybe it's luck? It happened to let me find the gene fragments needed for B cell gene editing."
luck……
This reason is too strong, and Professor Guo was speechless.
Scientific research is a process of trial and error. In this endless trial and error link, luck comes first.
With bad luck, you may not be able to find the required gene fragments from the 3 billion base pairs in one or two years, or even more than ten years.
With any luck...maybe like Lu Li, he found his goal in just over two months.
Therefore, even scientists have to talk about luck.
"Go! We will verify it right away!"
Professor Guo did not struggle with luck, got up quickly, walked out of the office, and shouted at the busy graduate and doctoral students outside: "Stop your work and go to the genetic laboratory immediately to verify the scientific research results, hurry up!"
Is it the verification of scientific research results again?
Is Lu Li’s scientific research results verification again?
They are all hard-working scientific research dogs, we can only follow the mentor's experience, but you continue to produce scientific research results.
It's...it hurts self-esteem!
The scientific research dogs driven by Professor Guo were able to fly one by one, but when they passed by Lu Li, they bowed their heads slightly.
When everyone came to the genetic laboratory, Professor Guo asked Lu Li to lead the experiment and directed many scientific research dogs to do the experiment.
A group of graduate students and doctoral students laid hands on Lu Li and kept extracting B cell samples, preparing transcriptases, and preparing shearing proteins.
Lu Li was sitting in front of the test bench, and various experimental materials were continuously gathered in Lu Li's hands.
Turn on the electron microscope, turn on the gene gun, and Lu Li kept editing the B cells, making samples one by one, and doing more than one hundred times in a row.
"Test passed! Genetic modification specimens have been obtained."
After Lu Li had done more than one hundred genetic modifications, Professor Guo, who performed the test later, had discovered B cell specimens that accurately completed the genetic modification.
"Successful! B-cell gene editing technology, verification is successful!"
Professor He beside him couldn't help cheering.
"congratulations!"
"Lu Li, congratulations!"
There was a round of applause in the laboratory, and everyone congratulated Lu Li for his successful technical verification.
This verification has proved that Lu Li's B cell gene editing technology is successful.
As for more than one hundred times to accurately prepare the required genetic modification specimens, this is normal.
With the current gene editing technology, even if the gene fragments to be edited are identified, the cut protein and transcriptase cannot accurately cut the desired position at once, and often cut the wrong place.
After a hundred experiments, a gene-edited correct specimen was obtained. This was the reason why Lu Li had determined the experimental data. This result was already very good.
If there is no such experimental data, I don’t know how many years of experimentation will be needed to hit the spot by chance!
"B-cell gene editing technology has been verified!"
Professor Guo also announced the results with excitement, and then said: "The next thing to do is to verify the CAR-T anti-cancer technology."
"This verification will take some time."
Professor He took the conversation and turned to Lu Li and smiled: "However, your theoretical research paper can be published. The experimental data must be kept secret!"
"understand!"
Lu Li nodded, "The verification of the results of anti-cancer technology needs to be arranged by Professor Guo."
"no problem."
Professor Guo agreed without hesitation.
...
In the afternoon, the Chinese Medical Journal received another paper from Fudan University.
"The application of gene editing technology for T cells and B cells in CAR-T technology."
Seeing this title, the editors of "Chinese Medicine" felt very tight. Application? Is the CAR-T technology mature?
See the author of the paper again...Lu Li!
Lu Li again!
This is only a few months? Lu Li has studied CAR-T technology to the extent that it can be applied?
The editor can be regarded as a half insider, and he naturally knows the importance of the mature CAR-T technology. This is tantamount to declaring to the world that cancer is no longer a terminal illness, and cancer can be treated!
This Lu Li... is really amazing!
With a secret admiration, the editor of the magazine quickly forwarded Lu Li's paper to the reviewers without hesitation.
...
"At present, CAR-T technology is not yet mature."
In a large auditorium of Yenching University, oncology expert, professor of Union Medical College, Professor Wang Zhijian, is giving an open class.
"Fudan's young people have made a major breakthrough in this technology. However, they still have not been able to solve the problem of immune factor storm."
"Science and technology are changing with each passing day. I believe that over time, maybe five years, maybe ten years, we will be able to overcome cancer, a chronic disease that accompanies human genes."
"Of course, this requires the students here to study hard and study hard!"
As he was talking, Professor Wang Zhijian suddenly saw that his assistant was holding his mobile phone and waving to him, his expression seemed a bit agitated and a bit anxious.
Ok? what happened?
Professor Wang Zhijian frowned. This assistant is his student. It stands to reason that it is impossible for the assistant to disturb him during class.
Since the assistant did this, there must be something very important.
"what's up?"
Professor Wang Zhijian stopped, turned his head to look at the assistant, his expression a little unhappy.
"Professor, the Chinese Medical Journal, I have transferred a manuscript that you need to review."
The assistant raised the phone and answered quickly.
"Reviewer? That's it?"
Professor Wang Zhijian's expression was a little ugly, "On this matter, you dare to interfere with my class?"
"Professor, this manuscript... is very important!"
The assistant quickly said: "This is Lu Li's paper. The latest paper on CAR-T technology."
Uh?
Professor Wang Zhijian was shocked, Lu Li? The latest technology of CAR-T?
"bring here!"
It is absolutely important to send the manuscripts for viewing at the risk of interrupting the class. Professor Wang Zhijian hurriedly asked his assistant to take the phone.
Because the audio equipment was not turned off during this conversation, the students sitting in the auditorium also heard this conversation.
So... there was a lot of discussion in the classroom.
"Lu Li? Is it the Lu Li from Fu Dan?"
"Lu Li has developed a new technology again?"
"Since I dare to interrupt Professor Wang's class, it must be a very important paper."
"Has Lu Li made another breakthrough in CAR-T technology? Has he matured this technology?"
"It should be impossible. Didn't you hear what Professor Wang said? Five years or even ten years later, it is possible to develop mature CAR-T technology."
While the students in the audience were talking about it, Professor Wang Zhijian was a little dazed.
"The application of gene editing technology for T cells and B cells in CAR-T technology."
This is a theoretical paper, in which the gene editing technology of T cells and B cells is oriented.
This kind of theoretical discussion paper can only serve as a reference, and it does not have much practical application value.
However, the title of this paper dared to write the word application, and at the end of the paper, there are the conclusions of repeated experiments of Fudan University.
This means...this technology has been verified. At least in the gene modification technology of B cells, Lu Li's paper is completely correct.
The posterity is awesome!
Professor Wang Zhijian suppressed the shock in his heart, put down his phone, and walked to the stage again.
"Classmates~EbookFREE.me~ I just received a paper."
Professor Wang Zhijian said to the students in the audience: "This is a paper on CAR-T technology published by Lu Li of Fudan University."
"In this paper, Lu Li proposed a new research direction and completed preliminary verification."
Speaking of this, Professor Wang Zhijian paused, and then said: "Just now, I said that CAR-T technology will take five or even ten years to mature, maybe...I was wrong!"
"Although the new generation of CAR-T technology developed by Lu Li still needs clinical trials to prove its efficacy. However, theoretically, perhaps... he has overcome cancer! From now on, cancer is no longer a terminal illness!"
"Fuck!"
"My God!"
At this moment, the audience was in an uproar.
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