Chapter 357: Have you conquered cancer?

After preparing this B cell, Lu Li immediately conducted human experiments.
This is another huge advantage of the virtual laboratory.
If it is a normal experimental procedure, it is necessary to conduct experiments on various small animals first. After a long period of time, human experiments are possible.
Even...many scientific research projects have no chance of being approved for human experiments.
Lu Li is different.
In the virtual laboratory, everything is virtualized, and it's all fake. He can do human experiments at will, do as he wants, without any restrictions at all.
This time too.
Lu Li directly injected the modified B cells into the experimental human body.
Then... nothing happened.
Ok? how come?
Lu Li was taken aback for a moment, and quickly picked up the testing equipment to carefully inspect the experimental human body.
Then, Lu Li found the reason!
The B cell that has blocked the ability to receive information is also a "quiet beautiful man"!
Without receiving any information, it will return to the lymph nodes with the lymph fluid, staying motionless in it, leisurely.
On the contrary, it is the other B cells that exist in the human body. After receiving the information, they copy wildly, releasing immune factors wildly, causing the immune system to go crazy.
So... B-cell "shutdown" is also impossible!
What should I do?
Lu Li's brain ached!
Forget it, take a break first. For more than a month, every day I stayed at home to do research, people are rusty!
Close the virtual laboratory, Lu Li got up and went out, and started running around the artificial lake in the Riverside Garden!
While running, Lu Li suddenly saw that there was also a girl in front of her doing morning exercises.
This girl was wearing a white tight-fitting sportswear, and her figure... it was really protruding forward, and she ran, really choppy.
Fortunately, Lu Li's will is as strong as steel. Even seeing this sultry scene, there is no fluctuation in his heart.
Even thinking...the weight of the chest and buttocks is too heavy, which affects the body's movement coordination. This kind of body structure does not conform to the laws of nature. In the cruel natural competition, it will definitely be eliminated by natural selection!
The next moment, Lu Li thought again...Humans no longer need to bear cruel natural selection! This kind of body structure is more suitable for gene transmission.
So, what is in the mind of a scientific research dog?
Just as Lu Li was thinking about serious scientific issues, the sultry girl heard the footsteps behind her and turned her head to look over.
Seeing Lu Li's handsome face, slender figure, and strong muscles, a light flashed in her eyes and a smile floated on her face.
"Hi!"
The girl waved to Lu Li and greeted her actively.
Uh...because of my handsome appearance and strong figure, it is very suitable as a combination of gene transmission, so under the control of genetic instinct, she took the initiative to greet me.
Sure enough, humans are just tools governed by genes!
Love is only the instinct of gene transmission, family affection is only the instinct to protect the continuation of genes, and human beings are just tools governed by genes.
A series of scientific explanations popped up in his mind, and Lu Li responded with a smile, "Hi!"
Nothing else, mainly...too big!
This is still genetic instinct!
"Do you live here? Why haven't I seen you before?"
The girl slowed down and ran side by side with Lu Li.
"Lived for more than a year."
Lu Li replied and asked, "Do you live here too? I have never seen you before!"
"Just came the other day!"
The girl smiled, "I used to be in Beijing. My sister lives here. I came to see my sister!"
"Oh! Beijing is a good place!"
Lu Li nodded, "I used to stay in Beijing for a while."
That is in the plot. In the actor plot and the master craftsman plot, Lu Li spent a long time in the capital.
"is it?"
As the girl ran, her white face was slightly sweaty, and she had the strange beauty of a jade ball.
"My name is Wen Wan, how about you?"
The girl introduced herself, then turned to ask Lu Li.
"My name is Lu Li."
"Land from?"
Before Lu Li could finish, the Wen Wan sister exclaimed, "You are the Lu Li who developed the new CAR-T technology? My God! I didn't expect to meet you here. What a coincidence!"
"My reputation is not so high, right?"
In this society, people only pay attention to the celebrity lace news, who cares about scientific research dogs?
"Introduce yourself. Wen Wan, a graduate student in basic medicine at Union Medical College."
Wen Wan smiled at Lu Li, "Big brother, don't you know how famous you are? You are our idol!"
"Oh! It turned out to be a companion!"
Lu Li nodded, "No wonder you know me."
"Boss, add a WeChat!"
Sister Wen Wan took out her mobile phone from her sports wristlet and raised her head towards Lu Li.
"WeChat?"
Lu Li paused, a flash of light in his mind.
Yeah! WeChat!
My previous thinking was wrong!
Why shut down B cells? Why make B cells unable to receive information? All I need to do is to prevent B cells from sending "WeChat" or "Moments"!
B cells receive the information from dendritic cells, activate the stress mechanism immediately, and continue to divide and proliferate.
Then... after these genetic modifications, "you can't post on WeChat" and "you can't post on B cells in Moments", they occupy a large area of ​​other normal B cell positions, and then "dead diet", what not to do!
In this way, the chance of immune factor outbreaks will be greatly reduced!
"Hahahaha!"
Lu Li laughed, turned around and ran away.
Behind her, the Wen Wan girl looked dull!
what does it mean? I asked you for a WeChat, is it so funny?
Also, what do you mean by slipping away like this?
Are scientific research dogs such straight men? You deserve it!
The Wen Wan sister stomped her feet heavily, her face was depressed!
...
Lu Li suddenly understood and found a breakthrough, where would he care about any girl?
Lu Li ran home, no matter how sweaty he was, Lu Li lay directly on the sofa, closed his eyes, and opened the virtual laboratory again.
"A virtual experimental human body with advanced cancer!"
When he arrived at the virtual laboratory, Lu Li gave the order directly, put on a white coat, and walked into the operating room.
Taking specimens from the experimental human body, picking up several specimens containing cancer cells, T cells and B cells, Lu Li hurriedly sat down in front of the test bench and continued the experiment.
The CAR-T experiment was performed first to prepare the required T cells, and Lu Li took out the B cell specimens and began to genetically modify the B cells.
The direction was right, and the experiment went smoothly.
Lu Li modified the genes of B cells with splicing proteins and blocked the ability of B cells to spread information.
Then... Lu Li picked up this B cell and injected it into the experimental human body. Using CAR-T technology, the gene-edited T cells were also injected.
The next moment... a miracle is born!
The "hostile sequence" of T cells discovered the presence of cancer cells in the experimental human body, which immediately stimulated the immune mechanism, split and proliferated frantically, and launched a fierce attack on cancer cells.
At this time, the T-cell army was dispatched to let the "intelligence" dendritic cells detect it, and hurriedly transmit information to the B cells, constantly calling for reinforcements, and constantly reporting news of the "outbreak of war".
Normal B cells are activated and divide and proliferate immediately. However... the B cells whose genes have been modified by Lu Li are also proliferating violently.
In this way, a lot of B cells of the "corpse site vegetarian meal" occupy the positions of logistics and command. Their inaction has significantly slowed the functioning of the immune mechanism.
The "immune factor storm" did not erupt on a large scale, nor did it cause the immune system to go crazy.
Although the experimental human body is still feverish and the immune response is still very intense, there is no such phenomenon that the immune system attacks vital organs indiscriminately, and does not cause heart failure, lung failure, or internal organ failure.
The experiment was successful!
Lu Li laughed.
The joy of overcoming a scientific research problem, and the sense of accomplishment of technological breakthroughs made Lu Chengtou very joyful!
From a certain perspective, CAR-T technology already has clinical value!
It reduces the immune response, avoids the immune factor storm, and prevents the immune system from attacking the human body indiscriminately, but it can accurately kill cancer cells. This is the best way to treat cancer.
It's just... this is still not a complete cure.
Once T cells have dried out the cancer cells in the body, they will self-destruct and will not exist in the body for a long time.
Then... after a period of time, maybe three years, maybe five years, or ten years, cancer cells will reappear.
People who have had cancer have cancer cell genes imprinted in their DNA, and recurrence is inevitable!
Of course, after recurrence, CAR-T technology can still be used for treatment!
However, there will be a new problem. In the battle between cancer cells and T cells, new mutations are likely to appear, and they are likely to have the ability to resist T cell attacks.
Just as viruses continue to mutate, the evolution of cancer cells is almost inevitable.
So...Although Lu Li has figured out the best treatment against cancer, he still hasn't completely overcome the cancer!
Lu Li was still not satisfied with his research results.
...
After closing the virtual laboratory, Lu Li took a bath, changed his clothes, sat down at the computer desk again, and started writing the paper.
"The application of gene editing technology for T cells and B cells in CAR-T technology."
Lu Li put forward a new theory. On the basis of modifying the T cell's "identification friend or foe system" and "calling friends" capabilities, he further proposed a plan to shield the command capabilities of B cells.
This is a mature technology that can be used clinically.
The paper is public and open to the whole world. In this thesis, Lu Li only expressed the theory, but did not express the experimental data and specific operating methods.
Immature technology can be disclosed. Mature technology must be kept secret.
After writing this purely theoretical thesis, Lu Li wrote a detailed experimental report, which stated the experimental data and experimental procedures.
This experimental report, Lu Li is going to hand it over to Fudan Medical College. As for how to deal with this scientific research result, that is what the leaders are considering!
After writing the thesis and experiment report separately, Lu Li took the test with a USB flash drive and hurried to Fudan Medical College.
"Xiao Lu, are you here?"
Seeing Lu Li's arrival, Professor He smiled and greeted him, "You... have you submitted your graduation thesis?"
"Ok!"
Lu Li nodded, "Teacher, I wrote a paper, which is still a CAR-T technology paper. Take a look."
With that said, Lu Li took out the USB flash drive and copied the papers and experiment reports into Professor He's computer.
"Your graduation thesis, I have to take a good look!"
Professor He reached for the mouse and clicked on Lu Li's paper.
"The application of T cell and B cell gene editing technology in CAR-T technology?"
Seeing this title, Professor He was shocked, turned his head to look at Lu Li, and repeatedly asked: "App? You said app? Are you sure?"
The word application is not something that can be written casually. Dare to say "application", that is already mature technology!
Is CAR-T technology mature enough to be applied?
Is Lu Li telling me that he has overcome cancer?
Professor He took a deep breath, only feeling that his heart was about to burst.
"I think this technology has matured. Take a look first!"
Lu Li had already done human experiments. Although it was a virtual human experiment, it was no different from a real human experiment.
This technology has been verified!
"Okay! I'll take a look first!"
Professor He took a sip from the teacup, trying to suppress the shock and excitement in his heart, but... the hands holding the teacup were shaking!
Set up his mind, Professor He opened the paper and read it word by word from beginning to end carefully.
After reading this time, Professor He almost knocked over his teacup!
Modify T cells and mark the genetic characteristics of cancer cells. This step is the technology disclosed by CAR-T, and everyone who studies this project all over the world knows this step.
Then came the second step. Lu Li made further modifications on the T cells, blocking the T cell's information transmission mechanism, so that the T cells no longer "call allies."
This step was made public in the last paper by Lu Li, and it has also been verified by major scientific research institutions around the world. It is even the best method for countless cancer hospitals to treat patients with advanced cancer.
Now, in this paper by Lu Li, the third step is to perform gene editing and modification on B cells to shield the command ability of B cells and prevent it from releasing immune factors madly.
From the theoretical analysis ~EbookFREE.me~ this is completely feasible.
After closing the paper, Professor He opened the experimental report next to it.
In the experiment report, Lu Li described all the operation steps in detail and wrote all the experimental data.
This experiment report is very detailed and can be repeated according to the experiment report.
Of course, Lu Li did not write out the data of human experiments. After all, it is not that easy to do human experiments in reality.
After reading the paper and the experimental report, Professor He raised his eyes to Lu Li, the expression on his face still a little sluggish.
"So... the cancer has been conquered by you?"
After being sluggish for a while, Professor He suddenly burst out laughing: "Hahahaha! My student has overcome cancer!"
"This is a great scientific achievement! From today, cancer is no longer a nightmare for mankind!"
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