Chapter 356: Come and see, my son is a scientist

Lu Li disapproved of the so-called "major breakthrough".
Even if the information transmission mechanism of T cells is shielded and the ability of T cells to call friendly forces is restricted, the immune response is still very intense.
Treatment with side effects stronger than the therapeutic effect is undoubtedly unsuccessful.
But... all anti-cancer methods so far have more severe side effects than treatment.
Commonly used radiation therapy, while radiation kills cancer cells, it also kills more normal cells. Radiation is also carcinogenic, almost like drinking poison to quench thirst.
Chemotherapy is tougher! It's totally killing one thousand enemies and self-defeating three thousand.
As for the most sophisticated CAR-T technology, the lethal effect is far greater than the therapeutic effect.
However...even if the side effects are so great, there are still countless people rushing to get treatment.
Being terminally ill, watching life go by day by day, this kind of fear makes people completely indifferent to the side effects, even if there is only one in 10,000, or even one in 100,000, they have to try.
Therefore, Lu Li actually underestimated his scientific research results.
...
Milliken.
In the ward of a private hospital, an old gentleman is lying on a hospital bed, and a doctor in a white coat is standing next to him.
"Dr. Henry, you came today to tell me that there is no hope anymore?"
On the old face, a pair of cloudy eyes revealed a deep unwillingness.
"No! On the contrary, sir!"
A smile appeared on Dr. Henry's face, "I bring you hope!"
"hope?"
The old man's eyes burst into light, "This is the best news I have heard recently! So...Where is my hope?"
"CAR-T technology!"
Dr. Henry replied: "Sir, a few days ago, a Chinese scientist named Lu Li improved the CAR-T technology, which can greatly reduce the factor storm caused by the immune response. So...your hope has appeared!"
"Thank God!"
The old man stretched out his hand and crossed his chest.
"You should thank the Chinese scientist Lu Li!"
Dr. Henry thought to himself: God did not save you, but... Lu Li's research results may be able to save you!
"Yes! Thank you Lu Li!"
There was a ray of hope in the old man's eyes.
...
The same scene is happening in many parts of the world.
Lu Li's improved CAR-T technology, gene editing technology that shields the T cell information transmission mechanism, has brought a glimmer of hope to countless desperate people.
This new technology that is still immature and cannot even be said to be successful will not save everyone's lives.
Only those who have a weak immune response or a relatively strong physical fitness that can survive the immune response will gain vitality.
However...for desperate people, this little hope is their motivation to persevere.
In the next month, hundreds of cancer patients survived because of Lu Li's new technology.
Suddenly, Lu Li and his T cell gene editing technology received widespread attention from the medical community, and it also had a huge impact in society.
"Our young scientist Lu Li has opened a new chapter in the fight against cancer!"
"Lu Li's new technology for treating cancer. No radiotherapy, no chemotherapy, or even surgery."
"Gene is the future. From Lu Li's T cell gene editing technology, talk about the impact of genetic engineering on humans."
"How far are we from conquering cancer? Lu Li tells you, this day is here!"
News reports about Lu Li appeared everywhere in the newspapers and on TV.
On Fudan University’s campus network, there was a floating good news: "Warm congratulations to classmate Lu Li from our school for achieving breakthrough and major research results in CAR-T technology!"
This upsurge of new anti-cancer technology also spread to Xichuan and to Yucheng.
When Xichuan TV and Yucheng TV learned that Lu Li was their own, the publicity became more lively.
"News from this station: my country's young scientist Lu Li has achieved major scientific research results in CAR-T anti-cancer technology and created a new technology for cancer treatment."
"Lu Li, from Xichuan Yucheng..."
Mother Lu, who was selling vegetables in the vegetable market, raised her head in surprise and looked at the TV screen hanging on the wall.
Land from? my son?
My son turned out to be a scientist?
Mother Lu rubbed her eyes, looked at it for a while, and found that the photo on TV was Lu Li and her son.
Some time ago, my son sent some money to the family, saying that he was going to Fudan to study for graduate school.
Now... has turned into a scientist?
Standing blankly for a while, Mother Lu laughed out loudly "again", "again" began to show off: "My son! This is my son! My son is a scientist!"
"Sister-in-law of the Lu family, your son turned out to be a scientist? That's amazing!"
"Yeah! Yeah! What about a scientist! That's amazing!"
The people around were full of envy and admiration.
Later, Mother Lu's food was given away again. Father Lu called his friends and friends to give him a drink again.
Uh... why do you say "again"?
...
"Xiao Lu, congratulations!"
Professor He put down the newspaper in his hand. The headline on the front page of the newspaper was a photo of Lu Li.
"Thank you!"
Lu Li smiled, and said, "CAR-T technology is still immature, and the praise from the outside world is a bit exaggerated."
"You don't want to belittle yourself!"
Professor He smiled and said: "Your improved CAR-T technology is currently one of the most effective ways to fight cancer."
Having said that, Professor He glanced at Lu Li and continued: "You have achieved major scientific research results. I exchanged with Dean Jiang and we all felt that your knowledge and scientific research capabilities have exceeded the level of graduate students. . So, you can graduate."
"what?"
Can I graduate early after only one year of graduate school?
"Graduate students and doctoral students do not actually have strict study time requirements. As long as your knowledge and scientific research capabilities meet the standards, you can graduate."
Professor He explained with a smile, and then asked Lu Li: "After you get your master's degree, what direction do you plan to study for a PhD?"
"Of course I will continue to learn from you!"
Lu Li felt that the cooperation with Professor He was very enjoyable, and he didn't bother to find another tutor. It would be more convenient to continue to study under Professor He.
"This one……"
Professor He hesitated and said: "You continue to study with me, of course I am very happy. But... your research direction is mainly genetics, I am afraid I can't help you much in this respect."
"Don't say that, I still have a lot to learn from you."
Lu Li has copied the knowledge of countless professors, and his knowledge accumulation has been very rich.
For Lu Li, what he needed was not guidance in knowledge, but convenience in scientific research.
Therefore, Professor He who gets along very happily is the most suitable tutor.
"okay then!"
Seeing that Lu Li's willingness to continue his Ph.D. study with him was very high, Professor He did not object, "Prepare yourself. At the end of the term, you will take the exam with this year's graduates and prepare a graduation thesis."
"Ok!"
Lu Li nodded and agreed.
After leaving Professor He's office, Lu Li returned to Binjiang Garden.
Sitting down in the study and turning on the computer, Lu Li was about to prepare his graduation thesis, when suddenly he saw hundreds of emails displayed in his email box.
"Why are there so many emails?"
Lu Li quickly clicked on the email.
Some of these e-mails are communication and discussion e-mails sent by scholars from various domestic research institutions and doctors from various tumor hospitals.
There are also some emails, which turned out to be cooperation invitation letters from various companies, and even employment letters from biopharmaceutical companies.
The treatment was very high, but it was a pity that Lu Lizhi was not here, and he didn't need to hug the thigh of "Golden Master Dad", so he didn't bother to pay attention.
To Lu Li's surprise, there were invitation letters from some research institutions from all over the world in the email, inviting Lu Li to come and discuss.
In these invitation letters, there is an exchange invitation from the American Oncology Society.
"An invitation from the American Cancer Society?"
A smile appeared on Lu Li's face, "Is this sent to the door to let me copy knowledge?"
In terms of cancer research, the American Oncology Society does have a deep accumulation. These accumulations are also of great value to Lu Li's research on the technology to overcome cancer, and it is worth copying.
It's just... Lu Li has no idea of ​​going to the U.S. for exchanges, so let's get a master's degree first!
He replied to some of the more important mails in the mailbox, leaving the other mails aside, Lu Li closed the mailbox.
He got up and walked out of the study, lying on the sofa, Lu Li closed his eyes and opened the virtual laboratory again.
The graduation season is two months away.
Lu Li was not worried about the graduation exam at all. It's just that... the graduation thesis has to be thoughtful.
If you just deal with it, the graduation thesis is not difficult. However, Lu Li had been hailed as a young scientist before, so naturally he could not fool a graduation thesis.
Let's continue research from CAR-T technology!
Last time, Lu Li reduced the intensity of the immune response by modifying the genes of the T cells and lowered the chance of the human immune system going crazy.
This genetic modification is very safe. Because after the T cell completes the task of killing the enemy, it will quickly self-destruct and will not exist for a long time.
Now, what Lu Li wants to modify is another type of immune cell-dendritic cell.
Dendritic cells are intelligence agents in the immune system. They will quickly transmit information about the human body being attacked by viruses to the immune system, triggering a violent immune response in the human body.
Under normal circumstances, the dendritic cell, an intelligence agent, is extremely beneficial to the human body. It is the key to the human body's fight against virus invasion.
However... In CAR-T technology, in order to prevent the immune system from going crazy, weakening or even shielding the intelligence ability of dendritic cells, it is more valuable for treatment.
However, dendritic cells exist for a long time and will not self-destruct. Once the intelligence ability of dendritic cells is modified, the body's immunity will be reduced.
This made Lu Li a little tangled.
Once the genes of dendritic cells are modified and their intelligence capabilities are weakened, it may reduce the chance of the immune system going crazy and allow T cells to smoothly kill cancer cells.
However... if the cancer stabilizes and won't get worse, but the patient died of a cold, how could this make sense?
Experiment first!
Human experiments that cannot be done in reality can be done at will in the virtual laboratory without any risk at all, which is very convenient.
Next, Lu Li began to gene-edit the dendritic cells.
The same is used to cut the protein, cut the DNA chain of dendritic cells, and shield the "intelligence ability" of dendritic cells!
The experiment is trial and error!
The advantages of the virtual laboratory are very obvious.
There is no consumption at all, and no money is burned at all. No matter how expensive the experiment, you can open it up.
One day, two days, one week, two weeks.
Lu Li did countless experiments and finally calibrated the "gene fragments" of dendritic cells representing intelligence capabilities.
Once the target is found, the operation is convenient.
The transcriptase calibrated gene fragments were injected into the dendritic cells together with the shearing protein, and a dendritic cell that shielded the intelligence ability was successfully prepared.
Then... Lu Li started doing human experiments.
Injecting this dendritic cell, which had shielded its intelligence capabilities, into the experimental human body, Lu Li began to observe the reaction of the experimental human body.
Then... no response.
After testing, Lu Li found that the dendritic cells injected into the experimental human body did not divide or proliferate, making it a "quiet beautiful man."
A dendritic cell without intelligence capabilities has absolutely no effect on the human body.
Is it necessary to modify all the dendritic cells in the human body?
There are 60 trillion cells in the human body. Even if there are not many dendritic cells, they are calculated in billions. This workload... When the patient is dead, the dendritic cell modification task has not been completed.
This road is totally unworkable!
Lu Li sighed long, it really wasn't that easy to get it done.
wrong! My thinking is wrong!
If you don't want to answer the phone, why would you want to shut down China Unicom? Isn't it enough to shut down directly?
Therefore, Lu Li targeted another type of immune cell.
B cells!
If T cells are the frontline forces, B cells are logistics and command.
Since the intelligence ability of dendritic cells cannot be shielded, the B cells are shut down and the dendritic cells cannot be received.
The logistics and command department of B cells cannot receive information from dendritic cells. UU read www.uukānshu. Com naturally will not produce an immune response, will not release immune factors, and will greatly reduce the madness of the human immune system.
More importantly, B cells, like T cells, will self-destruct after the battle is over, leaving only a very small number, which is stored in the lymph nodes. Most B cells will not exist in the human body for a long time.
So... Modifying B cells is the right direction.
Thinking of this, Lu Li immediately began to act.
It took another month for Lu Li to identify the gene fragments for B cells to receive information.
The most difficult part of genetic modification is here. Humans still know too little about genes. It takes a long time to interpret all three billion base pairs.
After finding out the gene fragments of B cells that receive messages, Lu Li used shear proteins to modify the genes of B cells, blocking the ability to receive messages.
Finally, a genetically modified B cell was prepared!
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