Chapter 64:

"Teacher, I have extracted a brand new antibiotic. The biological test is effective against Pseudomonas aeruginosa, but no one has tried it clinically."
There was a sound of rustling discussions in the ward. Xu Mingsheng was full of peaches and plums. Although many of his students gave up the pharmaceutical industry, the basic professional skills are still there. New antibiotics?
Everyone's eyes couldn't help but fall on this well-known "little brother".
Chen Sufen was taken aback for a moment, and then remembered Wang Jing's vows when she came back in the evening, and her heart could not help but beat quickly.
"A new antibiotic that is effective against Pseudomonas aeruginosa?" Chen Sufen almost tremblingly took over the pile of information in Li Zheng's hand, but as she looked at each item of data, the light in her eyes could not help but slowly dimmed.
Li Zheng’s experimental data is really not good-looking. Just looking at these experimental data and judging by strict antibiotic experimental standards, the antibiotics extracted by Li Zheng are too toxic and not suitable for human clinical treatment.
"Xiao Zheng, thank you, but you carbapenem antibiotics need to be perfected." Even at this point, Chen Sufen still maintained the tolerance and gentleness of a high-end intellectual woman.
"Mother..." He considered the sentence. If it was someone else, since they themselves refused, Li Zheng would never say one more word, but the person in front of him was Xu Mingsheng, the teacher he recognized.
"Teacher and teacher, I'm 80% sure." Li Zheng said, this is the biggest guarantee he can do.
Due to the particularity of the pharmaceutical industry, no matter whether it is a doctor or a pharmacist, it will never give any guarantee to the patient or the patient's family. The most they say is that I do my best. Because the weight of life is too heavy, not a doctor or anyone can afford it.
This kind of words that sound like perfunctory words to the patient or the patient's family is the protection of these practitioners. From the time when Li Zheng set foot in the biopharmaceutical field in his previous life, his mentors have instilled this philosophy in him continuously.
"I'm not 100% sure, absolutely don't make any guarantees to anyone!" These words still linger, but Li Zheng still said, "The molecular structure of carbapenems is already very stable, and its nephrotoxicity can be supplemented. The medicine is reduced to a level acceptable to the human body. The most important thing is that Pseudomonas aeruginosa is sensitive to it. Teacher, I know, in your opinion, I may be experimenting with your life... But..." Li Zheng He never felt that he was a talker, and he couldn't even express himself well when it came to excitement.
Sweat dripped out of his forehead. After two lifetimes, he was praised by many people as a pharmaceutical genius, and he has completely lost his usual steady wisdom and calmness.
The professors couldn't help but see the heat in their eyes. They fully understood how much risk Li Zheng was carrying when he said these words.
Chen Sufen could not help but feel a little moved. The reason as a doctor and the sensibility of being a family member of a dying patient are fighting fiercely in her heart. Reason and professional ethics tell her that she must not let patients inject drugs that are not qualified in clinical trials, but her Her husband is dying. Like the patients in the isolation room, the internal organs fail after the drug-resistant strains are infected with high temperature and dehydration. Her husband is running out of time!
Maybe... this so-called carbapenem antibiotic can really do wonders!
Xu Mingsheng has become a little confused because of the high temperature, and his ears are buzzing. Although Chen Sufen didn't say anything, Xu Mingsheng came out from the front line of the clinic, and he couldn't be clear in his heart. So many antibiotics were of no use at all. Is he infected with a drug-resistant strain, or a multi-drug resistant strain that is not sensitive to all antibiotics on the market.
Facing the imminent death, Xu Mingsheng couldn't tell what it was like. Perhaps because the fever was too high, he had no energy to think about it.
In a daze, he seemed to hear Li Zheng talking about drug-resistant strains and antibiotics, and Xu Mingsheng's spirit was refreshed.
"Experimental data of drug-resistant strains? Show me!" Xu Mingsheng still remembered that he was only halfway through the topic of drug-resistant strains. No, it should be said that he has just prepared the preliminary materials and completed the preparations for the start of the experiment.
As soon as the excitement of the old man scholar came up, he felt that his bewildered head had become sober because of the high fever, and he tried hard to stand up.
Upon seeing this, Xu Keqiang quickly took a cushion and placed it behind Xu Mingsheng.
He took the information Li Zheng handed over, "Old Chen, give me the glasses."
Chen Sufen glared at him, and took the glasses from the cabinet to Xu Mingsheng.
Xu Mingsheng looked at it page by page, sometimes stroking his palms and laughing sometimes, but he didn't know how hard he laughed, and Xu Keqiang and his disciples couldn't help but blush.
After seeing the last page of the biological experiment data of carbapenem antibiotics, Xu Mingsheng was silent for a minute, then turned to look at Chen Sufen, "You have a clinical trial agreement, and get a copy."
Chen Sufen's complexion changed drastically, "What are you going crazy! Didn't you read the experimental data! Less than 30%, which is not up to the standard for human clinical trials! Even if you sign a clinical trial agreement, it is invalid!"
Yes, every stage of drug trials has its own standards. In the biological experiment stage, if the experimental standards are not met on the white mouse and other organisms, it cannot enter the next stage. Strictly speaking, it is strictly a crime to enter the human clinical stage without authorization for drugs such as Li Zheng with a survival rate of less than 30% for mice!
"Old Chen, don’t forget who brought you out. My own body, I understand that the existing antibiotics are totally ineffective for me. I can still speak to you clearly in this way because You keep cooling down physically 24 hours a day. But it’s useless, maybe in less than half a day, I will lose consciousness, and then my organs will slowly fail."
Xu Mingsheng was very calm. He turned the page with the experimental data over and wrote word by word in the blank part at the back:
"I, Xu Mingsheng, voluntarily accepted the injection of carbapenem antibiotics developed by Mr. Li Zheng. I fully understand the danger of this test. All the consequences caused by this will be borne by me. No one is allowed to do any formalities. To be held accountable."
Signed Xu Mingsheng, February 17, 1983.
"I don't agree! I don't agree! At least not now! I don't agree!" Chen Sufen couldn't help screaming when he saw Xu Mingsheng's movements. At this time, Professor Chen was completely a collapsed family member of the patient. Now, it can't be now!" She kept repeating.
Chen Sufen also understood that Li Zheng's antibiotics may be Xu Mingsheng's only hope, but the probability of this hope is too low. If he does not receive the drug injection, perhaps Xu Mingsheng still has three to five days, perhaps what miracle can happen within these three to five days?
What she hopes is to wait and wait again, although she doesn't know when it will be suitable, but now! She can't accept it!
"Old Chen, as a biologist and dean of the Hong Kong University School of Medicine, I hope that even if you die, you will be worthy of dignity. There are still many infected people outside..." The excitement passed, Xu Mingsheng's spirit He weakened all of a sudden, and he was already struggling to speak.
"Why, why are you doing the experiment for them, not for you!" Chen Sufen finally said what was in her heart. When she said that, her face was pale, and she covered her face and went out. This proud Professor Chen understood that she Having lost her kindness and professional ethics as a doctor, she needs to calm down.
"Li Zheng, right? I heard my dad mention you several times. I was not convinced at first, but it turns out that I am inferior to you. You..." Xu Keqiang was silent for two seconds, "Do you know Mr. Kent of Merck? "
Merck? There was a glimmer of light in Li Zheng's eyes. In the Chinese translation, Merck was translated into Merck, Kent Blair, the chief director of Merck's New York laboratory. He had dealt with that old man in his previous life, a very cunning old fox.
"I don't know." Li Zheng remembered Xu Mingsheng's introduction to his son, a doctoral student at Harvard Medical School, and he had some guesses.
"Really..." The disappointment on Xu Keqiang's face flashed past.
Kent Blair once went to Harvard to give a speech. During the speech, he mentioned that a brand-new antibiotic had been born in Merck’s New York laboratory. Of course, he only mentioned a little bit, but there was news in the Harvard Medical Laboratory. The antibiotic discovered in Merck's New York laboratory may be effective against Pseudomonas aeruginosa!
After learning that his father was infected with Pseudomonas aeruginosa, Xu Keqiang contacted his tutor as soon as possible, hoping that he would pull the line from it and get the medicine that his father could use from Merck's New York laboratory.
But obviously his mentor didn't have such a big face to let Mr. Kent break the rules of the laboratory. He made countless calls to Kent Blair, until Blair was turned off by his annoying phone. But from the irritable Blair, he heard a term, carbapenem...
So when he heard carbapenem antibiotics from Li Zheng, the whole person was a little trembling with excitement.
"I will persuade my mother, and my dad will ask you!" He also signed his name on the agreement written by Xu Mingsheng, and then bowed deeply to Li Zheng.
Li Zheng raised his eyebrows slightly, he nodded, and without talking nonsense, took out a tube of reagent from the freezer incubator.
"Wang Jing, please come in, Professor Chen, and trouble her to prescribe kidney protection and nephrotoxic drugs to the teacher."
"Hey!" Wang Jing responded crisply, and ran to the door of the ward quickly.
But before she ran to the door, the ward door was pushed open, and Chen Sufen walked in calmly from outside the ward holding a tray of medicine.
"No, I have prepared the medicine, let's start." She said calmly.
The red liquid slowly entered Xu Mingsheng's body along the transparent PVC tube. The people in the ward watched Li Zheng slowly pushing the liquid in his hands without blinking.
He put the discarded needles in the metal tray, then took a step back and said to Chen Sufen: "Kidney-protecting medicine will be injected half an hour later, and the oral toxicity-relieving medicine can now be taken."
Chen Sufen nodded. Now that the experiment has started, she completely obeyed Li Zheng's instructions.
After putting the oral medicine into Xu Mingsheng's mouth, Chen Sufen clenched his fists tightly, and even the sound of the needle falling on the ground could be heard quietly in the ward.
Twenty minutes later
"What is the blush on the teacher's face?" a young man suddenly said.
Chen Sufen rushed forward and saw a red rash near Xu Mingsheng's ear. The rash was densely packed and there seemed to be liquid in it, which was not terrifying.