Chapter 65:

It is drug eruption, and the side effects of carbapenem antibiotics have begun.
"Monitor body temperature and electrocardiogram, teacher, can you hear my voice? Don't be afraid. If you feel vomiting, it is normal. Forbearance, half an hour will pass." Li Zheng looked at the mechanical watch on his wrist. Said calmly.
He has experienced numerous drug clinical trials, but this time is definitely the most special drug clinical trial.
"Wang Jing, are you ready? An intramuscular injection in five minutes."
Wang Jing swallowed and nodded vigorously. Her hand holding the syringe trembled slightly.
"Um" Xu Mingsheng suddenly turned blue and white, he suddenly turned to the bed and retched. The millet porridge that was not easy to feed in good morning vomited out.
Chen Sufen stepped forward and gently patted Xu Mingsheng on the back, "Li Zhengyao made Old Xu spit out."
"Fed in again!" Li Zheng said without thinking.
Xu Mingsheng's retching continued. He could no longer vomit, but his stomach was churning unceasingly like an earthquake, lying weakly on the side of the bed, almost vomiting the bitter bile.
"Old Xu, you must eat it!" Chen Sufen's eyes flashed with tears, she opened Xu Mingsheng's mouth, and forced the medicine into his mouth.
Xu Mingsheng's expression was painful, and he could not help shaking his head, but Chen Sufen was unrelenting, holding his mouth and refused to let go.
The bitter bile flowed along Xu Mingsheng's mouth and touched Chen Sufen's hand, but Chen Sufen still did not let go.
After the second hand turned twelve o'clock, Li Zheng looked up, "Wang Jing, intramuscular injection."
"Hey!" Wang Jing replied. She took a deep breath and grabbed one of Xu Mingsheng's arms. Xu Mingsheng's arm seemed very stiff because of violent vomiting.
"Professor Xu, take it easy, otherwise it will hurt a bit." Wang Jing said, while piercing the lower edge of Xu Mingsheng's deltoid muscle.
The medicine smoothly advanced into Xu Mingsheng's body, Wang Jing wiped the sweat bead on her forehead, and then looked at Li Zheng.
Li Zheng moved his gaze away from the watch, nodded to her, stopped talking, and then it was Xu Mingsheng himself.
He has seen Xu Mingsheng’s case and medication records. Xu Mingsheng has no history of antibiotic allergy, and there is no penicillin thiazole ring in carbapenems, and there is generally no cross-allergic reaction. Li Zheng's only concern is the nephrotoxicity of the drug.
Compared with imipenem, which was marketed in 1985, the carbapenem extracted by Li Zheng has not been bio-detoxified, and has not been subjected to drug component ratio and dilution, which requires the patient's own immune resistance. Strength and will to survive.
The next minute and every second was very difficult for the people in the ward. Xu Mingsheng's drug eruption and retching reaction became more and more intense, and the red rashes densely covered both arms and spread to the face.
The blue veins on Chen Sufen's forehead violently, everyone knew that she was holding back her grief.
Within an hour or two hours, Xu Mingsheng's reaction slowly became calm. He looked like a man who was almost drowning. He finally swam to the shore, breathing in fresh air.
"It's dropping! Old Xu's body temperature is dropping!" Chen Sufen trembled a little while looking at the numbers on the temperature monitor.
There was an instant commotion in the ward, and Xu Keqiang was almost attached to the body temperature monitor. It was 38.7 degrees Celsius, which was still a high temperature, but compared to the high temperature of more than thirty-nine degrees that lasted for several days, it was already a very surprising number.
Everyone almost looked at Li Zheng with reverence. This 17-year-old is not tall, is there really a genius in the world?
Now they can answer without hesitation, there is one in front of them!
"Master, the duration of the carbapenem nephrotoxicity outbreak is only three hours after the drug enters the human body. The teacher has passed the dangerous period, and his temperature will drop in another hour. He is almost done with some glucosamine."
Chen Sufen covered her mouth with excitement, and wiped the tears of excitement in her eyes, "Thank you, thank you Li Zheng!"
"Thank you, Li Zheng!" Xu Keqiang said.
"Little Junior Brother, you are really amazing!"
"Little Junior Brother, great!"
The dull atmosphere in the ward was swept away, everyone's heavy mood became relaxed, and the atmosphere in the room suddenly became warm and cheerful.
However, Li Zheng's tense nerves still did not relax. He looked at the watch on his wrist, and it was almost seven in the morning.
"Professor Chen, how is the patient in the isolation room outside?"
Li Zheng thought, with the example of Xu Mingsheng, the hospital should be more accepting of this brand new antibiotic.
When Chen Sufen heard the words, she put away her excitement slightly, and the expression on her face became serious.
"As of five o'clock in the morning, two people died in the isolation ward, three people entered the emergency room due to organ failure, and the rest are continuing to use antibiotics."
"Professor Chen, I think..." Before Li Zheng finished speaking, Chen Sufen interrupted.
"Mr. Li Zheng, on behalf of the Queen Mary Hospital, I now urge you to sell the carbapenem antibiotics in your hand as a special medicine temporarily purchased by our hospital." Chen Sufen looked serious, but looked at Li Zheng with gentle eyes. .
Li Zheng was taken aback for a moment, and then he realized that Professor Chen did this to protect him completely.
She purchases medicines on behalf of Queen Mary Hospital. If a patient dies due to drug toxicity, Queen Mary Hospital will be the first to bear the brunt. Although Li Zheng, the supplier, cannot escape the relationship, there is a lot of room for maneuverability.
Chen Sufen wanted to protect Li Zheng to the greatest extent under the worst plan.
Li Zheng couldn't help but feel a little moved. He opened his mouth and couldn't speak.
"Mother..."
Chen Sufen stepped forward and patted Li Zheng on the shoulder, "Good boy, you are the treasure that God bestows on mankind. You should stay in the laboratory and concentrate on your research. Leave the rest to us."
Chen Sufen is a professor in the Department of Clinical Medicine at the School of Medicine of Hong Kong University, but what few people know is that Chen Sufen still holds 3% of the shares in Queen Mary Hospital, so she can speak on behalf of the hospital, but it is not accurate. Have to discuss with the others in Queen Mary Hospital.
"Aqiang, look at your father, I'll go out." Then, she sorted out Xu Mingsheng's case, and then walked out with a thick pile of documents.
Li Zheng pursed his lips, and then followed.
"Mother, there are some things in the experimental notes, probably only I can explain."
"No! Absolutely not! How can drugs that are not on the market and have not even passed clinical trials be tried on our patients! This is a crime!" The deputy director of Queen Mary Hospital put the quilt on the table heavily, gasping for breath With roughness.
Chen Sufen slapped the table hard, "Chen Xuhua, who are you talking about committing a crime!"
Dean Chen's momentum suddenly weakened, "Teacher, I didn't mean that."
He scratched his head vigorously. Chen Xuhua has not slept for two days and two nights. He is the deputy dean of Queen Mary Hospital and also serves as the director of oncology surgery. This Pseudomonas aeruginosa infection started in the ICU ward of the oncology surgery. . When the infection first broke out, he only thought it was a mutation of the flu virus, and only ordered enhanced disinfection, but did not expect to cause drug-resistant bacteria infections throughout the hospital.
Chen Xuhua was annoyed by the self-blame in his heart. He has been on the front line almost the past two days, and he has been to the isolation room several times. He kept telling patients to have confidence and the will to survive.
When the patient looked at him with hope and asked him: "Dean Chen, are we still saving?", he nodded vigorously, tears streaming out.
He is still a doctor. With so many patients struggling with life and death, he can't save any of them!
"Teacher, to ensure drug safety, this is the basic professional ethics of a doctor! Physician guidelines, as well as the relevant provisions in the doctor's practice regulations..." Chen Xuhua was brought out by Chen Sufen, and he still respects the teaching mentors.
Chen Sufen's attitude also eased a little, "Xiao Chen, Old Xu, he has already taken medicine. This is his medication record and drug reaction report. Carbapenem antibiotics are effective! Physician guidelines and practice regulations are still mine. With you reading, I am clear about these terms, but Xiao Chen, do you still remember the first words I said to you for the first time in class? The patient's life is above everything else!"
Chen Xuhua looked in a trance when he heard the words. He seemed to have thought of something and didn't speak for a long time.
"I am 80% sure that I will be responsible for all the consequences of the patient's antibiotic injection." Chen Sufen's always gentle face is full of seriousness.
She stood there with not a tall body, Chen Xuhua felt as if she had returned to the classroom more than twenty years ago, and Professor Chen also had such an expression.
He remembered that Professor Chen walked into the classroom with a book in his arms. The first sentence was, "You will all be doctors in the future. What is the job of a doctor is to treat and save people. I hope you will never forget the patient wherever you go and wherever you are. His life is above all else!"
Chen Xuhua slammed the table and stood up, "I see, teacher." He took the Xu Mingsheng case in Chen Sufen's hand and began to study carefully.
Li Zheng stepped forward and explained the principle of action of carbapenems and the effects and defects of the drugs.
Chen Xuhua couldn't help nodding, and looked at Li Zheng with shock and appreciation, "It is said that the great chivalry is for the country and the people. Mr. Li Zheng, you are the chivalry among scholars!"
Li Zheng shook his head, "Dean Chen, you are absurd. I am just an experiment. Without the courage of you and Professor Chen, these things of mine would not be of any use."
Li Zheng is a high-end intellectual who sincerely admires the 80s. They pay more attention to being a human being while they are learning. In them, you can see the shining points of the Chinese nation. To be honest, if he wanted to accomplish this in his time, he probably needed to write a lot of commitments, promising that all the consequences of this matter would be borne by him personally.
Chen Xuhua smiled bitterly, "Mr. Adolf is not a problem, let me talk about it. Mr. Li Zheng, please go back and prepare enough medicine. The contents of your box are far from enough."
"Teacher, I call the doctors in the hospital to screen patients with normal renal function and immune resistance up to the standard, and first inject drugs."
Li Zheng's expression stiffened when he heard the words. Chen Xuhua's meaning was already clear. Patients with renal dysfunction and poor immunity should not be given injections for the time being. This means that these people have not even had the opportunity to challenge and have been sentenced to death. Li Zheng shook his head and smiled bitterly. The world is hard to come by. This is the best way to get the best of both worlds, isn't it?